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Aliases for MIR553 Gene

Subcategory (RNA class) for MIR553 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR553 Gene

  • MicroRNA 553 2 3 5
  • Hsa-Mir-553 3
  • MIRN553 3

External Ids for MIR553 Gene

ORGUL Members for MIR553 Gene

Previous HGNC Symbols for MIR553 Gene

  • MIRN553

Previous GeneCards Identifiers for MIR553 Gene

  • GC01P100520
  • GC01P100746

Summaries for MIR553 Gene

Entrez Gene Summary for MIR553 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR553 Gene

MIR553 (MicroRNA 553) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR553 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR553 Gene

Genomics for MIR553 Gene

GeneHancer (GH) Regulatory Elements for MIR553 Gene

Promoters and enhancers for MIR553 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I100362 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.7 +81.8 81822 0.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ATF1 ARNT YY1 POLR2B ATF7 SP3 MFSD14A SLC30A7 BRI3P1 HNRNPA1P68 CDC14A TRMT13 MIR553 ENSG00000235795 SASS6 BCAS2P2
GH01I100323 Enhancer 0.8 Ensembl ENCODE 11.9 +42.3 42336 0.4 ZNF335 ZNF121 ATF4 E2F5 ZMYM3 CEBPG FEZF1 ZBTB40 MIR553 GPR88 LOC646970 GC01P100283
GH01I100364 Enhancer 0.6 dbSUPER 11.7 +84.6 84631 3.1 HDAC1 MEIS2 IRF2 ZNF10 ZSCAN4 DACH1 MITF ZFHX2 ZNF316 FOXK2 CDC14A MIR553 BCAS2P2
GH01I100367 Enhancer 0.3 dbSUPER 11.5 +86.6 86632 0.6 PKNOX1 MIR553 CDC14A BCAS2P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR553 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR553 Gene

Genomic Locations for MIR553 Gene
chr1:100,281,241-100,281,308
(GRCh38/hg38)
Size:
68 bases
Orientation:
Plus strand
chr1:100,746,797-100,746,864
(GRCh37/hg19)

Genomic View for MIR553 Gene

Genes around MIR553 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR553 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR553 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR553 Gene

Proteins for MIR553 Gene

Post-translational modifications for MIR553 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR553 Gene

Domains & Families for MIR553 Gene

Gene Families for MIR553 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR553: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR553 Gene

Function for MIR553 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR553 Gene

Localization for MIR553 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR553 Gene

Pathways & Interactions for MIR553 Gene

SuperPathways for MIR553 Gene

No Data Available

Interacting Proteins for MIR553 Gene

Gene Ontology (GO) - Biological Process for MIR553 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR553 Gene

Drugs & Compounds for MIR553 Gene

No Compound Related Data Available

Transcripts for MIR553 Gene

mRNA/cDNA for MIR553 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR553 Gene

No ASD Table

Relevant External Links for MIR553 Gene

GeneLoc Exon Structure for
MIR553
ECgene alternative splicing isoforms for
MIR553

Expression for MIR553 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR553 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR553 Gene:

MIR553
genes like me logo Genes that share expression patterns with MIR553: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR553 Gene

Orthologs for MIR553 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR553 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-553 34
  • 100 (a)
OneToOne
Species where no ortholog for MIR553 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR553 Gene

ENSEMBL:
Gene Tree for MIR553 (if available)
TreeFam:
Gene Tree for MIR553 (if available)

Paralogs for MIR553 Gene

No data available for Paralogs for MIR553 Gene

Variants for MIR553 Gene

Sequence variations from dbSNP and Humsavar for MIR553 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000150682 -- 100,280,849(+) A/G upstream_transcript_variant
rs1000162035 -- 100,281,423(+) A/G downstream_transcript_variant
rs1001163737 -- 100,279,762(+) A/T upstream_transcript_variant
rs1001165586 -- 100,281,307(+) G/A non_coding_transcript_variant
rs1001484497 -- 100,281,558(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR553 Gene

Variant ID Type Subtype PubMed ID
nsv522987 CNV gain 19592680

Additional Variant Information for MIR553 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR553

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR553 Gene

Disorders for MIR553 Gene

Additional Disease Information for MIR553

No disorders were found for MIR553 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR553 Gene

Publications for MIR553 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  2. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58

Products for MIR553 Gene

Sources for MIR553 Gene

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