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Aliases for MIR551A Gene

Subcategory (RNA class) for MIR551A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR551A Gene

  • MicroRNA 551a 2 3 5
  • Hsa-Mir-551a 3
  • Mir-551a 3
  • MIRN551A 3

External Ids for MIR551A Gene

Previous HGNC Symbols for MIR551A Gene

  • MIRN551A

Previous GeneCards Identifiers for MIR551A Gene

  • GC01M003469

Summaries for MIR551A Gene

Entrez Gene Summary for MIR551A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR551A Gene

MIR551A (MicroRNA 551a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR551A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR551A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR551A Gene

Genomics for MIR551A Gene

Regulatory Elements for MIR551A Gene

Enhancers for MIR551A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F003539 1.2 Ensembl ENCODE 12.6 +20.8 20768 2.4 MLX ARID4B DMAP1 ZNF48 SLC30A9 MCM3 SP3 SP5 MXD4 MIER2 MEGF6 MIR551A ENSG00000238260 TPRG1L LOC105378610 LOC105378608 GC01M003505
GH01F003538 1.2 Ensembl ENCODE 12.6 +22.4 22389 0.8 ATF1 MLX ARID4B ZNF48 SLC30A9 GLIS2 MCM3 SP3 SP5 KAT8 MIR551A TPRG1L ENSG00000238260 MEGF6 LOC105378610 TP73-AS1 LOC105378608 GC01M003505
GH01F003565 0.7 ENCODE 0.8 -4.6 -4622 0.2 CTCF MAZ ZNF654 MAX TRIM22 REST ZBTB7A RAD21 ZFP69B KLF16 MEGF6 ENSG00000238260 TPRG1L MIR551A LOC105378607
GH01F003595 1.3 FANTOM5 Ensembl ENCODE 0.3 -37.1 -37071 4.3 TBP RFX1 L3MBTL2 BHLHE40 MAX ZIC2 HIC1 ZFHX2 ZNF766 EGR1 MEGF6 TPRG1L TP73 LOC105378607 MIR551A
GH01F003587 0.7 ENCODE 0.3 -26.7 -26722 0.2 SOX13 GATAD2A CTCF SOX5 ZNF687 ESRRA PKNOX1 FOXA3 NRF1 KLF17 LOC105378607 MIR551A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR551A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR551A Gene

Chromosome:
1
Start:
3,560,695 bp from pter
End:
3,560,790 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR551A Gene

Genes around MIR551A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR551A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR551A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR551A Gene

ORGUL Member Location for MIR551A Gene

ORGUL Member Location for MIR551A gene

Proteins for MIR551A Gene

Post-translational modifications for MIR551A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR551A Gene

Domains & Families for MIR551A Gene

Gene Families for MIR551A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR551A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR551A Gene

Function for MIR551A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR551A Gene

Localization for MIR551A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR551A Gene

Pathways & Interactions for MIR551A Gene

SuperPathways for MIR551A Gene

No Data Available

Interacting Proteins for MIR551A Gene

Gene Ontology (GO) - Biological Process for MIR551A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR551A Gene

Transcripts for MIR551A Gene

fRNAdb Secondary structures for MIR551A Gene

  • hsa-miR-551a_MIMAT0003214_Homo_sapiens_miR-551a_mature

mRNA/cDNA for MIR551A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR551A Gene

No ASD Table

Relevant External Links for MIR551A Gene

GeneLoc Exon Structure for
MIR551A
ECgene alternative splicing isoforms for
MIR551A

Expression for MIR551A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR551A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR551A Gene:

MIR551A
genes like me logo Genes that share expression patterns with MIR551A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR551A Gene

Orthologs for MIR551A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR551A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-551a 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-551a 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-551a 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-551a 35
  • 84 (a)
OneToOne
Species where no ortholog for MIR551A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR551A Gene

ENSEMBL:
Gene Tree for MIR551A (if available)
TreeFam:
Gene Tree for MIR551A (if available)

Paralogs for MIR551A Gene

No data available for Paralogs for MIR551A Gene

Variants for MIR551A Gene

Sequence variations from dbSNP and Humsavar for MIR551A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111824684 -- 3,560,933(+) CATCC(A/G)TCTAG intron-variant, upstream-variant-2KB
rs112289529 -- 3,561,245(+) GCTGA(A/G)GAGCA intron-variant, upstream-variant-2KB
rs112961419 -- 3,561,047(+) CCCAA(A/G)TCTGC intron-variant, upstream-variant-2KB
rs115678263 -- 3,561,187(+) GATGC(A/G)GGCTT intron-variant, upstream-variant-2KB
rs115746547 -- 3,560,920(+) ACCCT(C/T)TGGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR551A Gene

Variant ID Type Subtype PubMed ID
esv2758915 CNV gain 17122850
nsv1004180 CNV gain 25217958
nsv1009360 CNV gain 25217958
nsv1012423 CNV gain 25217958
nsv470687 CNV loss 18288195
nsv545126 CNV loss 21841781
nsv830203 CNV loss 17160897
nsv951959 CNV deletion 24416366

Relevant External Links for MIR551A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR551A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR551A Gene

Disorders for MIR551A Gene

Relevant External Links for MIR551A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR551A

No disorders were found for MIR551A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR551A Gene

Publications for MIR551A Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Extracellular metabolic energetics can promote cancer progression. (PMID: 25601461) Loo J.M. … Tavazoie S.F. (Cell 2015) 3 64
  3. miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3. (PMID: 22469786) Li Z. … Park S.S. (Cancer Lett. 2012) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR551A Gene

Sources for MIR551A Gene

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