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Aliases for MIR550A3 Gene

Subcategory (RNA class) for MIR550A3 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR550A3 Gene

  • MicroRNA 550a-3 2 3 5
  • Hsa-Mir-550a-3 3
  • Mir-550a-3 3

External Ids for MIR550A3 Gene

Previous GeneCards Identifiers for MIR550A3 Gene

  • GC07U903200
  • GC07M029721
  • GC07M029722
  • GC07M029740
  • GC07M029758
  • GC07M029769
  • GC07M029790
  • GC07M029803

Summaries for MIR550A3 Gene

Entrez Gene Summary for MIR550A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR550A3 Gene

MIR550A3 (MicroRNA 550a-3) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR550A3 Gene

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR550A3

Additional gene information for MIR550A3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR550A3 Gene

Genomics for MIR550A3 Gene

Regulatory Elements for MIR550A3 Gene

Enhancers for MIR550A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H029681 0.5 Ensembl 0.7 -0.3 -273 0 SMARCE1 SMARCA4 ZNF341 KDM1A DPY19L2P3 LOC646762 MIR550A3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR550A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR550A3 Gene

Chromosome:
7
Start:
29,680,734 bp from pter
End:
29,680,828 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR550A3 Gene

Genes around MIR550A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR550A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR550A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR550A3 Gene

ORGUL Member Location for MIR550A3 Gene

ORGUL Member Location for MIR550A3 gene

Proteins for MIR550A3 Gene

Post-translational modifications for MIR550A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR550A3 Gene

Domains & Families for MIR550A3 Gene

Gene Families for MIR550A3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR550A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR550A3 Gene

Function for MIR550A3 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR550A3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR550A3 Gene

Localization for MIR550A3 Gene

Gene Ontology (GO) - Cellular Components for MIR550A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR550A3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR550A3 Gene

Pathways & Interactions for MIR550A3 Gene

SuperPathways for MIR550A3 Gene

No Data Available

Interacting Proteins for MIR550A3 Gene

Gene Ontology (GO) - Biological Process for MIR550A3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR550A3 Gene

Drugs & Compounds for MIR550A3 Gene

No Compound Related Data Available

Transcripts for MIR550A3 Gene

fRNAdb Secondary structures for MIR550A3 Gene

  • FR062099

mRNA/cDNA for MIR550A3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR550A3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR550A3 Gene

No ASD Table

Relevant External Links for MIR550A3 Gene

GeneLoc Exon Structure for
MIR550A3
ECgene alternative splicing isoforms for
MIR550A3

Expression for MIR550A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR550A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR550A3 Gene:

MIR550A3
genes like me logo Genes that share expression patterns with MIR550A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR550A3 Gene

Orthologs for MIR550A3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR550A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-550-1 34
  • 67 (a)
ManyToMany
Species where no ortholog for MIR550A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR550A3 Gene

ENSEMBL:
Gene Tree for MIR550A3 (if available)
TreeFam:
Gene Tree for MIR550A3 (if available)

Paralogs for MIR550A3 Gene

No data available for Paralogs for MIR550A3 Gene

Variants for MIR550A3 Gene

Sequence variations from dbSNP and Humsavar for MIR550A3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002718527 -- 29,681,875(+) GAATA(A/C)CAAGC intron-variant, upstream-variant-2KB
rs1004474031 -- 29,682,387(+) CTGAA(A/T)AAACA intron-variant, upstream-variant-2KB
rs1004515681 -- 29,682,558(+) CTCAG(C/T)AAGGC intron-variant, upstream-variant-2KB
rs1004587607 -- 29,682,174(+) TTTCA(C/T)TTTCT intron-variant, upstream-variant-2KB
rs1006145268 -- 29,681,171(+) TTAAT(C/T)ACAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR550A3 Gene

Variant ID Type Subtype PubMed ID
dgv11249n54 CNV gain 21841781
dgv235n111 CNV duplication 26073780
dgv6313n100 CNV gain 25217958
dgv6314n100 CNV gain 25217958
dgv6315n100 CNV loss 25217958
esv24568 CNV gain+loss 19812545
esv2734186 CNV deletion 23290073
esv2759521 CNV gain 17122850
esv3576300 CNV gain 25503493
esv3612697 CNV loss 21293372
esv3612698 CNV gain 21293372
nsv1068321 OTHER inversion 25765185
nsv1148830 OTHER inversion 26484159
nsv469585 CNV gain 16826518
nsv516270 CNV gain+loss 19592680
nsv606486 CNV loss 21841781
nsv8072 CNV gain+loss 18304495
nsv824045 CNV gain 20364138
nsv830935 CNV gain 17160897

Relevant External Links for MIR550A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR550A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR550A3 Gene

Disorders for MIR550A3 Gene

Relevant External Links for MIR550A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR550A3

No disorders were found for MIR550A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR550A3 Gene

Publications for MIR550A3 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3 60
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  4. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR550A3 Gene

Sources for MIR550A3 Gene

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