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Aliases for MIR550A3 Gene

Subcategory (RNA class) for MIR550A3 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR550A3 Gene

  • MicroRNA 550a-3 2 3 5
  • Hsa-Mir-550a-3 3
  • Mir-550a-3 3

External Ids for MIR550A3 Gene

Previous GeneCards Identifiers for MIR550A3 Gene

  • GC07U903200
  • GC07M029721
  • GC07M029722
  • GC07M029740
  • GC07M029758
  • GC07M029769

Summaries for MIR550A3 Gene

Entrez Gene Summary for MIR550A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR550A3 Gene

MIR550A3 (MicroRNA 550a-3) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR550A3 Gene

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR550A3

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR550A3 Gene

Genomics for MIR550A3 Gene

Regulatory Elements for MIR550A3 Gene

Enhancers for MIR550A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F029680 0.5 Ensembl 0.8 -0.2 -173 0.4 ARID1B ZNF341 KDM1A PRR15 DPY19L2P3 LOC646762 MIR550A3
GH07F029681 0.4 Ensembl 0.8 -0.9 -873 0.6 ZFHX2 ENSG00000223813 PRR15 ZNRF2P2 LOC646762 MIR550A3
GH07F029673 0.8 Ensembl 0.4 +6.9 6928 0.2 HDAC1 LEF1 PKNOX1 ZNF316 FOXK2 NCOR1 SCRT2 NFE2 SMARCE1 RNF2 GC07P029667 MIR550A3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR550A3 on UCSC Golden Path with GeneCards custom track

Promoters for MIR550A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001890414 -1973 800 ZNF664

Genomic Location for MIR550A3 Gene

Chromosome:
7
Start:
29,680,734 bp from pter
End:
29,680,828 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR550A3 Gene

Genes around MIR550A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR550A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR550A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR550A3 Gene

ORGUL Member Location for MIR550A3 Gene

ORGUL Member Location for MIR550A3 gene

Proteins for MIR550A3 Gene

Post-translational modifications for MIR550A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR550A3 Gene

Domains & Families for MIR550A3 Gene

Gene Families for MIR550A3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR550A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR550A3 Gene

Function for MIR550A3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR550A3 Gene

Localization for MIR550A3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR550A3 Gene

Pathways & Interactions for MIR550A3 Gene

SuperPathways for MIR550A3 Gene

No Data Available

Interacting Proteins for MIR550A3 Gene

Gene Ontology (GO) - Biological Process for MIR550A3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR550A3 Gene

Transcripts for MIR550A3 Gene

fRNAdb Secondary structures for MIR550A3 Gene

  • FR062099

mRNA/cDNA for MIR550A3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR550A3 Gene

No ASD Table

Relevant External Links for MIR550A3 Gene

GeneLoc Exon Structure for
MIR550A3
ECgene alternative splicing isoforms for
MIR550A3

Expression for MIR550A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR550A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR550A3 Gene:

MIR550A3
genes like me logo Genes that share expression patterns with MIR550A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR550A3 Gene

Orthologs for MIR550A3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR550A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-550-1 35
  • 67 (a)
ManyToMany
Species where no ortholog for MIR550A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR550A3 Gene

ENSEMBL:
Gene Tree for MIR550A3 (if available)
TreeFam:
Gene Tree for MIR550A3 (if available)

Paralogs for MIR550A3 Gene

No data available for Paralogs for MIR550A3 Gene

Variants for MIR550A3 Gene

Sequence variations from dbSNP and Humsavar for MIR550A3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10245523 -- 29,682,812(+) GTGCT(A/G)AAAGT intron-variant, upstream-variant-2KB
rs111675224 -- 29,682,284(+) AGTTT(C/T)ACAAA intron-variant, upstream-variant-2KB
rs111997526 -- 29,680,569(+) ATTGT(A/T)CATAA intron-variant, downstream-variant-500B
rs113821008 -- 29,680,777(+) ATCTT(-/ACA)ACAAC intron-variant, nc-transcript-variant
rs115923387 -- 29,681,086(+) TTAGA(A/G)AGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR550A3 Gene

Variant ID Type Subtype PubMed ID
nsv830935 CNV gain 17160897
nsv824045 CNV gain 20364138
nsv8072 CNV gain+loss 18304495
nsv606486 CNV loss 21841781
nsv516270 CNV gain+loss 19592680
nsv469585 CNV gain 16826518
nsv1148830 OTHER inversion 26484159
nsv1068321 OTHER inversion 25765185
esv3612698 CNV gain 21293372
esv3612697 CNV loss 21293372
esv3576300 CNV gain 25503493
esv2759521 CNV gain 17122850
esv2734186 CNV deletion 23290073
esv24568 CNV gain+loss 19812545
dgv6315n100 CNV loss 25217958
dgv6314n100 CNV gain 25217958
dgv6313n100 CNV gain 25217958
dgv235n111 CNV duplication 26073780
dgv11249n54 CNV gain 21841781

Relevant External Links for MIR550A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR550A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR550A3 Gene

Disorders for MIR550A3 Gene

Relevant External Links for MIR550A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR550A3

No disorders were found for MIR550A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR550A3 Gene

Publications for MIR550A3 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) FriedlAonder M.R. … Rajewsky N. (Nucleic Acids Res. 2012) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 3 64

Products for MIR550A3 Gene

Sources for MIR550A3 Gene

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