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Aliases for MIR549A Gene

Subcategory (RNA class) for MIR549A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR549A Gene

  • MicroRNA 549a 2 3 5
  • MicroRNA 549 2 3
  • Hsa-Mir-549a 3
  • Hsa-Mir-549 3
  • Mir-549a 3
  • MIRN549 3
  • MIR549 3

External Ids for MIR549A Gene

Previous HGNC Symbols for MIR549A Gene

  • MIRN549
  • MIR549

Previous GeneCards Identifiers for MIR549A Gene

  • GC15M081137

Summaries for MIR549A Gene

Entrez Gene Summary for MIR549A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR549A Gene

MIR549A (MicroRNA 549a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR549A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR549A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR549A Gene

Genomics for MIR549A Gene

Regulatory Elements for MIR549A Gene

Enhancers for MIR549A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G080805 1.2 Ensembl ENCODE 12.6 +36.9 36872 0.7 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF121 MIR549A GC15P080826 CEMIP
GH15G080870 0.9 ENCODE 12.1 -29.0 -29019 2.1 HDGF ATF1 PKNOX1 ARNT CREB3L1 NFIB NFRKB RAD21 TCF12 ZNF766 MIR549A MESD ARNT2 GC15M080848 GC15P080893
GH15G080868 0.5 ENCODE 12.1 -25.1 -25142 0.2 HDAC2 KDM1A ZBTB33 MIR549A ARNT2 GC15M080848 GC15P080893
GH15G080867 0.4 ENCODE 12.1 -25.6 -25587 0.0 ZBTB33 MIR549A ARNT2 GC15M080848 GC15P080893
GH15G080796 0.2 ENCODE 12.2 +45.4 45449 0.1 MIR549A ARNT2 CEMIP GC15P080826
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR549A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR549A Gene

Chromosome:
15
Start:
80,841,978 bp from pter
End:
80,842,073 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR549A Gene

Genes around MIR549A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR549A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR549A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR549A Gene

ORGUL Member Location for MIR549A Gene

ORGUL Member Location for MIR549A gene

Proteins for MIR549A Gene

Post-translational modifications for MIR549A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR549A Gene

Domains & Families for MIR549A Gene

Gene Families for MIR549A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR549A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR549A Gene

Function for MIR549A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR549A Gene

Localization for MIR549A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR549A Gene

Pathways & Interactions for MIR549A Gene

SuperPathways for MIR549A Gene

No Data Available

Interacting Proteins for MIR549A Gene

Gene Ontology (GO) - Biological Process for MIR549A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR549A Gene

Transcripts for MIR549A Gene

fRNAdb Secondary structures for MIR549A Gene

  • hsa-miR-549a_MIMAT0003333_Homo_sapiens_miR-549a_mature

mRNA/cDNA for MIR549A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR549A Gene

No ASD Table

Relevant External Links for MIR549A Gene

GeneLoc Exon Structure for
MIR549A
ECgene alternative splicing isoforms for
MIR549A

Expression for MIR549A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR549A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR549A Gene:

MIR549A
genes like me logo Genes that share expression patterns with MIR549A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR549A Gene

Orthologs for MIR549A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR549A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-549 35
  • 99 (a)
OneToOne
Species where no ortholog for MIR549A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR549A Gene

ENSEMBL:
Gene Tree for MIR549A (if available)
TreeFam:
Gene Tree for MIR549A (if available)

Paralogs for MIR549A Gene

No data available for Paralogs for MIR549A Gene

Variants for MIR549A Gene

Sequence variations from dbSNP and Humsavar for MIR549A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000412901 -- 80,842,506(+) GCGGG(G/T)GGATC intron-variant, upstream-variant-2KB
rs1000465381 -- 80,843,113(+) TCACT(A/C)CATGC intron-variant, upstream-variant-2KB
rs1006067135 -- 80,843,384(+) TATCA(A/G)TCAAG intron-variant, upstream-variant-2KB
rs1006123868 -- 80,841,779(+) TGGGA(A/G)TTAAT intron-variant, downstream-variant-500B
rs1008070849 -- 80,841,848(+) GCCTT(C/G)CCTAA intron-variant, downstream-variant-500B

Relevant External Links for MIR549A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR549A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR549A Gene

Disorders for MIR549A Gene

Relevant External Links for MIR549A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR549A

No disorders were found for MIR549A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR549A Gene

Publications for MIR549A Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR549A Gene

Sources for MIR549A Gene

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