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Aliases for MIR548U Gene

Subcategory (RNA class) for MIR548U Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR548U Gene

  • MicroRNA 548u 2 3 5
  • Hsa-Mir-548u 3

External Ids for MIR548U Gene

Previous GeneCards Identifiers for MIR548U Gene

  • GC06U902075
  • GC06P057088
  • GC06P057254

Summaries for MIR548U Gene

Entrez Gene Summary for MIR548U Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548U Gene

MIR548U (MicroRNA 548u) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548U Gene

Genomics for MIR548U Gene

Regulatory Elements for MIR548U Gene

Enhancers for MIR548U Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F057386 0.3 FANTOM5 0.8 -3.4 -3392 0.2 KIAA1586 MIR548U GC06M057367
GH06F057427 0.3 FANTOM5 0.3 +37.8 37790 0.3 GUSBP4 MIR548U ENSG00000266579
GH06F057422 0.2 ENCODE 0.3 +33.5 33524 1.3 TEAD4 SIN3A CTBP1 ZBTB48 POLR2A MAZ MNT KLF4 DPF2 OSR2 RAB23 LINC00680 MIR548U ENSG00000266579
GH06F057431 0.6 Ensembl ENCODE 0.2 +42.8 42768 3.4 RNF2 HLF CEBPB EBF1 LINC00680 PRIM2 LOC101927268 MIR548U ENSG00000266579
GH06F057434 0.4 Ensembl 0.2 +44.8 44769 0.2 PRIM2 MIR548U ENSG00000266579
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR548U on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR548U Gene

Chromosome:
6
Start:
57,390,132 bp from pter
End:
57,390,212 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR548U Gene

Genes around MIR548U on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548U Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548U Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548U Gene

Proteins for MIR548U Gene

Post-translational modifications for MIR548U Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548U Gene

Domains & Families for MIR548U Gene

Gene Families for MIR548U Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR548U: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548U Gene

Function for MIR548U Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548U Gene

Localization for MIR548U Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548U Gene

Pathways & Interactions for MIR548U Gene

SuperPathways for MIR548U Gene

No Data Available

Interacting Proteins for MIR548U Gene

Gene Ontology (GO) - Biological Process for MIR548U Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR548U Gene

Transcripts for MIR548U Gene

mRNA/cDNA for MIR548U Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548U Gene

No ASD Table

Relevant External Links for MIR548U Gene

GeneLoc Exon Structure for
MIR548U
ECgene alternative splicing isoforms for
MIR548U

Expression for MIR548U Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548U Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548U Gene:

MIR548U
genes like me logo Genes that share expression patterns with MIR548U: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR548U Gene

Orthologs for MIR548U Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548U Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
Species where no ortholog for MIR548U was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548U Gene

ENSEMBL:
Gene Tree for MIR548U (if available)
TreeFam:
Gene Tree for MIR548U (if available)

Paralogs for MIR548U Gene

No data available for Paralogs for MIR548U Gene

Variants for MIR548U Gene

Sequence variations from dbSNP and Humsavar for MIR548U Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456742 -- 57,390,027(+) AAGCA(C/T)AACAT intron-variant, upstream-variant-2KB
rs10949039 -- 57,388,636(+) CAGGA(C/T)TTGAA intron-variant, upstream-variant-2KB
rs10949040 -- 57,388,892(+) ATGTG(A/C)AGCCA intron-variant, upstream-variant-2KB
rs111877300 -- 57,389,245(+) AGCCA(C/G)AGGCC intron-variant, upstream-variant-2KB
rs112174392 -- 57,388,297(+) GGAAG(C/T)GGGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR548U Gene

Variant ID Type Subtype PubMed ID
dgv10677n54 CNV gain 21841781
dgv1184e214 CNV gain 21293372
dgv3320n106 CNV duplication 24896259
dgv5967n100 CNV gain 25217958
dgv5968n100 CNV gain 25217958
esv2453782 CNV gain 19546169
esv2759432 CNV gain 17122850
nsv1077472 CNV duplication 25765185
nsv1140634 CNV deletion 24896259
nsv1147971 CNV duplication 26484159
nsv470820 CNV gain 18288195
nsv528053 CNV loss 19592680
nsv603193 CNV gain 21841781
nsv818418 CNV gain 17921354
nsv950183 CNV duplication 24416366
nsv970125 CNV duplication 23825009

Relevant External Links for MIR548U Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548U

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548U Gene

Disorders for MIR548U Gene

Relevant External Links for MIR548U

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR548U

No disorders were found for MIR548U Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548U Gene

Publications for MIR548U Gene

  1. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR548U Gene

Sources for MIR548U Gene

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