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Aliases for MIR548M Gene

Subcategory (RNA class) for MIR548M Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR548M Gene

  • MicroRNA 548m 2 3
  • Hsa-Mir-548m 3
  • MIRN548M 3

External Ids for MIR548M Gene

Previous Symbols for MIR548M Gene

  • MIRN548M

Summaries for MIR548M Gene

Entrez Gene Summary for MIR548M Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548M Gene

MIR548M (MicroRNA 548m) is an RNA Gene, and belongs to the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548M Gene

Genomics for MIR548M Gene

Genomic Location for MIR548M Gene

Start:
95,063,141 bp from pter
End:
95,063,226 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR548M Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR548M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548M Gene

No data available for Regulatory Elements for MIR548M Gene

Proteins for MIR548M Gene

Post-translational modifications for MIR548M Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548M Gene

Domains for MIR548M Gene

Gene Families for MIR548M Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR548M: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548M Gene

Function for MIR548M Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR548M Gene

Localization for MIR548M Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548M Gene

Pathways for MIR548M Gene

SuperPathways for MIR548M Gene

No Data Available

Interacting Proteins for MIR548M Gene

Gene Ontology (GO) - Biological Process for MIR548M Gene

None

No data available for Pathways by source for MIR548M Gene

Transcripts for MIR548M Gene

mRNA/cDNA for MIR548M Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548M Gene

No ASD Table

Relevant External Links for MIR548M Gene

GeneLoc Exon Structure for
MIR548M
ECgene alternative splicing isoforms for
MIR548M

Expression for MIR548M Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR548M Gene

Orthologs for MIR548M Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548M Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 80 (a)
OneToOne
Species with no ortholog for MIR548M:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548M Gene

ENSEMBL:
Gene Tree for MIR548M (if available)
TreeFam:
Gene Tree for MIR548M (if available)

Paralogs for MIR548M Gene

No data available for Paralogs for MIR548M Gene

Variants for MIR548M Gene

Sequence variations from dbSNP and Humsavar for MIR548M Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4030409 -- 95,063,650(+) TATAT(-/GAGTAT)ATTTA upstream-variant-2KB
rs5950157 -- 95,064,050(+) TGTAA(A/C)GTCTT upstream-variant-2KB
rs6522880 -- 95,064,959(+) taata(A/C)ttata upstream-variant-2KB
rs12010198 -- 95,064,978(+) acaaa(A/C)caaaa upstream-variant-2KB
rs12010231 -- 95,064,974(+) aaaaa(A/C)aaaac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR548M Gene

Variant ID Type Subtype PubMed ID
nsv888512 CNV Loss 21882294
dgv2112e1 CNV Complex 17122850
nsv464602 CNV Gain 19166990
nsv888521 CNV Loss 21882294

Relevant External Links for MIR548M Gene

HapMap Linkage Disequilibrium report
MIR548M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR548M Gene

Disorders for MIR548M Gene

No disorders were found for MIR548M Gene.

No data available for UniProtKB/Swiss-Prot for MIR548M Gene

Publications for MIR548M Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3
  3. miR-1279, miR-548j, miR-548m, and miR-548d-5p binding sites in CDSs of paralogous and orthologous PTPN12, MSH6, and ZEB1 Genes. (PMID: 23957009) Ivashchenko A.T. … Berillo O.A. (Biomed Res Int 2013) 3
  4. A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas. (PMID: 24216476) Lwin T. … Tao J. (J. Clin. Invest. 2013) 3

Products for MIR548M Gene

Sources for MIR548M Gene

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