Aliases for MIR548L Gene
Subcategory (RNA class) for MIR548L Gene
Quality Score for this RNA gene is
External Ids for MIR548L Gene
- HGNC: 35292
- Entrez Gene: 100302275
- Ensembl: ENSG00000221230
- miRBase: hsa-mir-548l
ORGUL Members for MIR548L Gene
Previous HGNC Symbols for MIR548L Gene
- MIRN548L
Previous GeneCards Identifiers for MIR548L Gene
- GC00U922821
- GC11M093840
- GC11M094199
Summaries for MIR548L Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR548L Gene
MIR548L (MicroRNA 548l) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR548L Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548L Gene
Genomics for MIR548L Gene
GeneHancer (GH) Regulatory Elements for MIR548L Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11I094472 | Enhancer | 1 | Ensembl ENCODE | 0.4 | -6.8 | -6776 | 1.9 | PKNOX1 SMAD1 BACH1 BMI1 BATF IRF4 NFATC1 ATF7 BCLAF1 IKZF2 | ENSG00000255893 MRE11 MIR548L | |
GH11I094448 | Enhancer | 0.7 | ENCODE | 0.4 | +17.0 | 16957 | 1.4 | SOX13 FOXA2 JUN SIN3A CEBPG ETS1 FOXK2 PRDM10 FOSL2 FOS | MRE11 ANKRD49 ENSG00000255893 MIR548L GPR83 |
Regulatory Element Products
Genomic Locations for MIR548L Gene
- chr11:94,466,495-94,466,580
- (GRCh38/hg38)
- Size:
- 86 bases
- Orientation:
- Minus strand
- chr11:94,199,661-94,199,746
- (GRCh37/hg19)
Genomic View for MIR548L Gene
- Cytogenetic band:
-
- 11q21 by Ensembl
- 11q21 by Entrez Gene
- 11q21 by HGNC


RefSeq DNA sequence for MIR548L Gene
Proteins for MIR548L Gene
Post-translational modifications for MIR548L Gene
Antibody Products
- Search GeneTex for Antibodies for MIR548L
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR548L
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- Search GeneTex for Proteins for MIR548L
No data available for DME Specific Peptides for MIR548L Gene
Domains & Families for MIR548L Gene
Gene Families for MIR548L Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548L Gene
Function for MIR548L Gene
Animal Model Products
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-
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CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR548L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548L Gene
Localization for MIR548L Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548L Gene
Transcripts for MIR548L Gene
mRNA/cDNA for MIR548L Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR548L
- Applied Biological Materials CRISPR for MIR548L
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for MIR548L
Inhibitory RNA Products
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Clone Products
- GenScript: Custom all cDNA clones Services for MIR548L
- VectorBuilder custom plasmid, inducible vectors for MIR548L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR548L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR548L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR548L Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR548L Gene:
MIR548LPrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548L Gene
Orthologs for MIR548L Gene
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-548l 34 |
|
OneToOne |
- Species where no ortholog for MIR548L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR548L Gene
No data available for Paralogs for MIR548L Gene
Variants for MIR548L Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11020793 | benign, Hereditary cancer-predisposing syndrome, not specified, Ataxia-telangiectasia-like disorder 1 | 94,467,879(-) | A/C | upstream_transcript_variant | |
rs140067184 | other, Malignant tumor of urinary bladder | 94,467,199(-) | G/A | upstream_transcript_variant | |
rs140528613 | uncertain-significance, Ataxia-telangiectasia-like disorder 1, Hereditary cancer-predisposing syndrome | 94,467,820(-) | C/A/T | upstream_transcript_variant | |
rs1805365 | benign, Hereditary cancer-predisposing syndrome, not specified, Ataxia-telangiectasia-like disorder 1 | 94,467,796(-) | A/C/G | upstream_transcript_variant | |
rs200367125 | other, Malignant tumor of urinary bladder | 94,466,405(-) | T/C | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2671948 | CNV | deletion | 23128226 |
Additional Variant Information for MIR548L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR548L
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548L Gene
Disorders for MIR548L Gene
Additional Disease Information for MIR548L
No disorders were found for MIR548L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548L Gene
Publications for MIR548L Gene
- MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5. (PMID: 28218742) Cai H … Jia L (Laboratory investigation; a journal of technical methods and pathology 2017) 3 58
- microRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway. (PMID: 25245053) Liu C … Zhou R (Journal of cancer research and clinical oncology 2015) 3 58
- Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
Products for MIR548L Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR548L
- VectorBuilder custom plasmid, inducible vectors for MIR548L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR548L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR548L
- Search GeneTex for Proteins for MIR548L
Sources for MIR548L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew