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Aliasesfor MIR548L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section GeneCards Plus Subcategory (RNA class): miRNAQuality score for this RNA gene is 8 Aliases MicroRNA 548l 1 2 MIRN548L1 2 hsa-mir-548l2 mir-548l9
External Ids: HGNC: 35292 1 Entrez Gene: 100302275 2 Ensembl: ENSG00000221230 7 Export aliases for MIR548L gene to outside databases Previous GC identifers: GC00U922821 GC11M093840
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Summariesfor MIR548L gene (According to Entrez Gene ,
GeneCards ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Plus Entrez Gene summary for MIR548L Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation ofgene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs aretranscribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that canbe either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzymeto produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by thecytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. Themature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs throughimperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization ofthe target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009) GeneCards Summary for MIR548L Gene: MIR548L (microRNA 548l) is an RNA gene, and is affiliated with the miRNA class.
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Genomic Viewsfor MIR548L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 75) ,
Regulatory elements and Epigenetics data according to
QIAGEN , and/or
SwitchGear Genomics )About This Section GeneCards Plus Regulatory elements: Search for regulatory transcription factor binding sites for MIR548L Other transcription factors Search Chromatin IP Primers for MIR548L Epigenetics: DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR548L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Ensembl cytogenetic band: 11q21 HGNC chromosome: 11 MIR548L Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M094199: view genomic region miRBase )
(about GC identifiers )
Start: 94,199,661 bp from pter End:
94,199,746 bp from pter
Size: 86 bases Orientation:
minus strand
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Proteinsfor MIR548L gene
(According to
1 UniProtKB ,
HORDE ,
2 neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec ,
Cloud-Clone Corp. ,
eBioscience , and/or
antibodies-online ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences ,
Cloud-Clone Corp. ,
eBioscience , and/or
antibodies-online ,
Antibodies by
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam ,
Cloud-Clone Corp ,
antibodies-online ,
and/or others.)
About This Section GeneCards Plus UniProtKB: --
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Domains /for MIR548L gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section GeneCards Plus HGNC Gene Families: MIR: ncRNAs / Micro RNAs
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Functionfor MIR548L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
genOway ,
QIAGEN
and/or HOMER ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
Gene Editing from DNA2.0 ,
Clones from OriGene ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs
and/or Addgene ,
Cell Lines from GenScript ,
ESI BIO ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Flow cytometry from eBioscience ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus
Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for MIR548L Browse ESI BIO Cell Lines and PureStem Progenitors for MIR548L In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR548L
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Localizationfor MIR548L gene
(According to UniProtKB , COMPARTMENTS Subcellular localization database ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus
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Pathways & Interactionsfor MIR548L gene
(SuperPaths according to PathCards ,
Pathways according to
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
QIAGEN ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene) .
About This Section GeneCards Plus
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR548L Interactions: Search GeneGlobe Interaction Network for MIR548L
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Drugs & Compoundsfor MIR548L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience ,
ApexBio ,
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB )
About This Section GeneCards Plus
Browse compounds at ApexBio Browse Tocris compounds for MIR548L
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Transcriptsfor MIR548L gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
OriGene ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
and/or Addgene ,
Primers from
OriGene , and/or
QIAGEN ,
Flow cytometry from eBioscience
)About This Section GeneCards Plus 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000408303(miRNA) GeneLoc Exon Structure
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Expression for MIR548L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MaxQB ,
plus additional links to
SOURCE , and/or
BioGPS , and/or
UniProtKB ,QIAGEN ,
Primers from
OriGene , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GeneCards Plus
Expression evidence for MIR548L:miRBase See probesets specificity/sensitivity at GeneAnnot CGAP TAG: --
MIR548L Protein expression data from MOPED1 2 3 : Custom PCR Arrays for MIR548L Primer Browse OriGene qPCR Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR548L Search QuantiTect SYBR Green Assays in human, mouse, rat MIR548L Search QuantiFast Probe-based Assays in human, mouse, rat MIR548L In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR548L
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Orthologsfor MIR548L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section GeneCards Plus Orthologs for MIR548L gene from 1 species (see representative species ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chimpanzee Mammalia ptr-mir-548l6
ptr-mir-548l
99(a)
1 ↔ 1
11(92243001-92243085) ENSPTRG00000034811
ENSEMBL Gene Tree for MIR548L (if available)TreeFam Gene Tree for MIR548L (if available)
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Paralogsfor MIR548L gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section GeneCards Plus
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Genomic Variantsfor MIR548L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) , the Human Cytochrome P450 Allele
Nomenclature Database , and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN )
About This Section GeneCards Plus Site Specific Mutation Identification with PCR Assays
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Disorders
/ Diseasesfor MIR548L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section GeneCards Plus
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Publicationsfor MIR548L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section GeneCards Plus PubMed articles for MIR548L gene integrated from 10 sources :(articles sorted by number of sources associating them with MIR548L) Utopia : connect your pdf to the dynamic
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PubMed id 18285502) 1 (Genome Res. 2008) miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832) 1 (Nucleic Acids Res. 2006)
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External Searches for MIR548L gene (in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section GeneCards Plus
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Genome Databases showing MIR548L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section GeneCards Plus
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Other Databases showing MIR548L gene
(According to HUGE )
About This Section GeneCards Plus --
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Specialized Databases showing MIR548L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , UniProtKB/TrEMBL , and/or others, e.g. Wikipedia and GeneReviews , via UniProtKB/Swiss-Prot )About This Section GeneCards Plus
Name Description PharmGKB entry for MIR548L Pharmacogenomics, SNPs, Pathways
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About This Section GeneCards Plus Patent Information for MIR548L gene: MIR548L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MIR548L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , eBioscience , antibodies-online , and/or others, Gene Editing from DNA2.0 . Clones from OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Addgene , Cell lines from GenScript , and ESI BIO , Flow cytometery from eBioscience , PCR Arrays from QIAGEN , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , Enzo Life Sciences , and/or
ApexBio , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from genOway )About This Section GeneCards Plus
Block miRNA regulation of human, mouse, rat MIR548L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MIR548L DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR548L Predesigned siRNA for gene silencing in human mouse rat Search QuantiFast Probe-based Assays in human, mouse, rat MIR548L Search QuantiTect SYBR Green Assays in human, mouse, rat MIR548L Custom PCR Arrays for MIR548L Search Chromatin IP Primers for MIR548L Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR548L Search GeneGlobe Interaction Network for MIR548L Search Regulatory tfbs for MIR548L
Search Tocris compounds for MIR548L
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR548L
Search ThermoFisher Antibodies for MIR548L
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR548L
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