Aliases for MIR548L Gene
Subcategory (RNA class) for MIR548L Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR548L Gene
- HGNC: 35292
- Entrez Gene: 100302275
- Ensembl: ENSG00000221230
- miRBase: hsa-mir-548l
ORGUL Members for MIR548L Gene
Previous HGNC Symbols for MIR548L Gene
- MIRN548L
Previous GeneCards Identifiers for MIR548L Gene
- GC00U922821
- GC11M093840
- GC11M094199
Summaries for MIR548L Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR548L Gene
MIR548L (MicroRNA 548l) is an RNA Gene, and is affiliated with the miRNA class.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548L Gene
Genomics for MIR548L Gene
Regulatory Elements for MIR548L Gene
Enhancers for MIR548L Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G094472 | 1.1 | Ensembl ENCODE | 0.4 | -6.8 | -6776 | 1.9 | TBP PKNOX1 TBL1XR1 BMI1 ZBTB40 CBX5 RELB IKZF2 CREM CBFB | MRE11 ENSG00000255893 MIR548L |
| GH11G094448 | 0.8 | ENCODE | 0.4 | +17.0 | 16958 | 1.4 | SOX13 FOXA2 JUN SIN3A CEBPG RARA FOXK2 FOS PRDM10 MIXL1 | MRE11 ANKRD49 ENSG00000255893 MIR548L GPR83 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MIR548L on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MIR548L Gene
- Chromosome:
- 11
- Start:
- 94,466,495 bp from pter
- End:
- 94,466,580 bp from pter
- Size:
- 86 bases
- Orientation:
- Minus strand
Genomic View for MIR548L Gene
Genes around MIR548L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q21 by Ensembl
- 11q21 by Entrez Gene
- 11q21 by HGNC
MIR548L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR548L Gene
Proteins for MIR548L Gene
Post-translational modifications for MIR548L Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR548L
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR548L
- Origene Custom Protein Services for MIR548L
- Search GeneTex for Proteins for MIR548L
Assay Products
No data available for DME Specific Peptides for MIR548L Gene
Domains & Families for MIR548L Gene
Gene Families for MIR548L Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548L Gene
Function for MIR548L Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR548L
-
- Search ViGene Biosciences for MIR548L
CRISPR Products
- Browse CRISPR knockouts for MIR548L
miRNA Products
- Search ViGene Biosciences for MIR548L
Inhibitory RNA Products
- Search ViGene Biosciences for MIR548L
Clone Products
- GenScript: Custom all cDNA clones Services for MIR548L
- VectorBuilder custom plasmid, inducible vectors for MIR548L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR548L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for MIR548L
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548L Gene
Localization for MIR548L Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548L Gene
Transcripts for MIR548L Gene
mRNA/cDNA for MIR548L Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR548L
miRNA Products
- Search ViGene Biosciences for MIR548L
Inhibitory RNA Products
- Search ViGene Biosciences for MIR548L
Clone Products
- GenScript: Custom all cDNA clones Services for MIR548L
- VectorBuilder custom plasmid, inducible vectors for MIR548L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR548L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for MIR548L Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR548L Gene:
MIR548LPrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548L Gene
Orthologs for MIR548L Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-548l 35 |
|
OneToOne |
- Species where no ortholog for MIR548L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR548L Gene
No data available for Paralogs for MIR548L Gene
Variants for MIR548L Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs371077728 | Pathogenic | 94,467,821(+) | CAGTC(A/C/G/T)TACAA | nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, missense, stop-gained | |
| rs876659343 | Likely pathogenic | 94,467,811(-) | GCGAG(C/T)AAGTC | upstream-variant-2KB, splice-donor-variant | |
| rs786201488 | Likely benign | 94,467,825(-) | CCTCT(C/T)GTACG | nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon | |
| rs786201824 | Likely benign | 94,467,822(-) | CTTGT(A/G)CGACT | nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon | |
| rs876659934 | Likely benign | 94,467,837(-) | CAGCC(A/G)GAGAA | nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2671948 | CNV | deletion | 23128226 |
Relevant External Links for MIR548L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR548L
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548L Gene
Disorders for MIR548L Gene
Relevant External Links for MIR548L
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR548L
No disorders were found for MIR548L Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548L Gene
Publications for MIR548L Gene
- microRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway. (PMID: 25245053) Liu C. … Zhou R. (J. Cancer Res. Clin. Oncol. 2015) 3 64
- Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
Products for MIR548L Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR548L
- GenScript: Custom all cDNA clones Services for MIR548L
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- Browse GenScript CRISPR for MIR548L
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR548L
- VectorBuilder custom plasmid, inducible vectors for MIR548L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR548L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR548L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (128) Genetics Home Reference
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- (135) Gene Damage Index
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer