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MIR548I4 Gene

RNA gene GIFtS: 17
GCID: GC0XM083480

MicroRNA 548i-4

(Previous symbol: MIRN548I4)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 548i-4¹ ²
MIRN548I4¹ ²
MIR548I-4²
hsa-mir-548i-4²
mir-548i-4⁹

External Ids:	HGNC: 35355¹	Entrez Gene: 100302191²	Ensembl: ENSG00000221494⁷

ORGUL members:
	miRBase: MI0006424

Export aliases for MIR548I4 gene to outside databases

Previous GC identifers: GC00U922982 GC0XM083368

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR548I4 Gene:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of

gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are

transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can

be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme

to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the

cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The

mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through

imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of

the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR548I4 Gene:

MIR548I4 (microRNA 548i-4) is an RNA gene, and is affiliated with the miRNA class.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Search for regulatory transcription factor binding sites for MIR548I4
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR548I4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq21.1

MIR548I4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR548I4 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM083480: view genomic region (via miRBase) (about GC identifiers)

Start:	83,480,760 bp from pter	End:	83,480,836 bp from pter
Size:	77 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

MIR: ncRNAs / Micro RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000408567(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR548I4:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MIR548I4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548I4 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	--	--	75(a)	many ↔ many	2B(206563578-206563666) ENSPTRG00000041383

ENSEMBL Gene Tree for MIR548I4 (if available)
TreeFam Gene Tree for MIR548I4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189807092^1,2		--	83480359(+)	`CTGCCC/GTCTTC`	1	--	ds500¹		0	--	--	--	--
rs150647779^1,2		--	83480658(+)	`GTTAAC/TTGAGA`	1	--	ds500¹		0	--	--	--	--
rs139757170^1,2		--	83480686(+)	`AGTTAC/TCCTGA`	1	--	ds500¹		0	--	--	--	--
rs72632467^1,2	C	--	83480764(+)	`TATAGA/GTTGGT`	1	--	nc-transcript-variant		0	--	--	--	--
rs5968275^1,2	C,F,A,H	--	83481317(+)	`CAGCAG/CCAGGC`	1	--	us2k¹		6		NS EA NA	420
rs182099059^1,2		--	83481953(+)	`TTACTC/GCATAG`	1	--	us2k¹		0	--	--	--	--
rs6622977^1,2	C,F,H	--	83482062(+)	`TGTCAA/GTGTAA`	1	--	us2k¹		9		NS EA NA	554
rs145276014^1,2	C	--	83482100(+)	`ATGAGG/TTTGGA`	1	--	us2k¹		0	--	--	--	--
rs186610248^1,2		--	83482115(+)	`GGGGCG/TTAACC`	1	--	us2k¹		0	--	--	--	--
rs193281980^1,2		--	83482138(+)	`ACCCCA/GAGAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MIR548I4 (83480760 - 83480836 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for MIR548I4 (see all 20): About this table

Variant ID	Type	Subtype	PubMed ID
esv2735308	CNV	Deletion	23290073
esv2735307	CNV	Deletion	23290073
esv2735309	CNV	Deletion	23290073
dgv1246e199	CNV	Deletion	23128226
nsv5997	CNV	Insertion	18451855
esv273229	CNV	Insertion	20981092
esv270321	CNV	Insertion	20981092
esv270385	CNV	Insertion	20981092
esv272196	CNV	Insertion	20981092
esv22430	CNV	Loss	19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MIR548I4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MIR548I4)

Utopia: connect your pdf to the dynamic
world of online information

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PubMed id 18285502)¹ Morin R.D....Marra M.A. (Genome Res. 2008)
miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832)¹ Griffiths-Jones S....Enright A.J. (Nucleic Acids Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100302191	HGNC: 35355	Ensembl:ENSG00000221494	miRBase: hsa-mir-548i-4	euGenes: HUgn100302191
ECgene: MIR548I4	H-InvDB: MIR548I4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MIR548I4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR548I4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MIR548I4 gene:
Search GeneIP for patents involving MIR548I4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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