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Aliases for MIR548E Gene

Subcategory (RNA class) for MIR548E Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR548E Gene

  • MicroRNA 548e 2 3 5
  • Hsa-Mir-548e 3
  • MIRN548E 3

External Ids for MIR548E Gene

Previous HGNC Symbols for MIR548E Gene

  • MIRN548E

Previous GeneCards Identifiers for MIR548E Gene

  • GC00U923163
  • GC10P112739

Summaries for MIR548E Gene

Entrez Gene Summary for MIR548E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548E Gene

MIR548E (MicroRNA 548e) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548E Gene

Genomics for MIR548E Gene

Regulatory Elements for MIR548E Gene

Enhancers for MIR548E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G110992 0.9 Ensembl ENCODE 0.7 +4.2 4226 1.4 GATAD2A PKNOX1 CBFB EP300 PRDM6 CEBPA HNF4A FOS BBIP1 SHOC2 ADRA2A ENSG00000232470 PDCD4 MIR548E GC10P111035
GH10G110972 0.5 Ensembl 0.4 -16.2 -16226 0.2 ZSCAN5C SP2 ZBTB17 BBIP1 SHOC2 ADRA2A MIR548E RPL13AP6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR548E on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR548E Gene

Chromosome:
10
Start:
110,988,926 bp from pter
End:
110,989,013 bp from pter
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR548E Gene

Genes around MIR548E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548E Gene

Proteins for MIR548E Gene

Post-translational modifications for MIR548E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548E Gene

Domains & Families for MIR548E Gene

Gene Families for MIR548E Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR548E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548E Gene

Function for MIR548E Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548E Gene

Localization for MIR548E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548E Gene

Pathways & Interactions for MIR548E Gene

SuperPathways for MIR548E Gene

No Data Available

Interacting Proteins for MIR548E Gene

Gene Ontology (GO) - Biological Process for MIR548E Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR548E Gene

Drugs & Compounds for MIR548E Gene

No Compound Related Data Available

Transcripts for MIR548E Gene

mRNA/cDNA for MIR548E Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548E Gene

No ASD Table

Relevant External Links for MIR548E Gene

GeneLoc Exon Structure for
MIR548E
ECgene alternative splicing isoforms for
MIR548E

Expression for MIR548E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR548E Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548E Gene:

MIR548E
genes like me logo Genes that share expression patterns with MIR548E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548E Gene

Orthologs for MIR548E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-548e 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR548E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548E Gene

ENSEMBL:
Gene Tree for MIR548E (if available)
TreeFam:
Gene Tree for MIR548E (if available)

Paralogs for MIR548E Gene

No data available for Paralogs for MIR548E Gene

Variants for MIR548E Gene

Sequence variations from dbSNP and Humsavar for MIR548E Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001658856 -- 110,987,576(+) TAATA(C/T)CCAAA intron-variant, upstream-variant-2KB
rs1002665142 -- 110,989,189(+) ATCCA(C/T)AAATA intron-variant, downstream-variant-500B
rs1003751772 -- 110,989,110(+) TAGGA(C/T)TTGAA intron-variant, downstream-variant-500B
rs1005731487 -- 110,988,604(+) GGTTA(A/G)AAGTA intron-variant, upstream-variant-2KB
rs1006190431 -- 110,989,016(+) GAAGA(A/T)TGTTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR548E Gene

Variant ID Type Subtype PubMed ID
dgv974n100 CNV loss 25217958
dgv975n100 CNV loss 25217958
nsv1035422 CNV loss 25217958
nsv1035602 CNV loss 25217958
nsv1047412 CNV loss 25217958
nsv7211 OTHER inversion 18451855
nsv831985 CNV gain+loss 17160897

Relevant External Links for MIR548E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548E Gene

Disorders for MIR548E Gene

No disorders were found for MIR548E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for MIR548E Gene

Publications for MIR548E Gene

  1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin R.D. … Marra M.A. (Genome Res. 2008) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR548E Gene

Sources for MIR548E Gene

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