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Aliases for MIR548B Gene

Subcategory (RNA class) for MIR548B Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR548B Gene

  • MicroRNA 548b 2 3
  • Hsa-Mir-548b 3
  • MIRN548B 3

External Ids for MIR548B Gene

Previous Symbols for MIR548B Gene

  • MIRN548B

Summaries for MIR548B Gene

Entrez Gene Summary for MIR548B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548B Gene

MIR548B (MicroRNA 548b) is a RNA Gene, and belongs to miRNA RNA class.

fRNAdb sequence ontologies for MIR548B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR548B Gene

Genomics for MIR548B Gene

Genomic Location for MIR548B Gene

Start:
119,069,047 bp from pter
End:
119,069,143 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR548B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR548B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548B Gene

ORGUL Member Location for MIR548B Gene

ORGUL Member Location for MIR548B gene

No data available for Regulatory Elements for MIR548B Gene

Proteins for MIR548B Gene

Post-translational modifications for MIR548B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548B Gene

Domains for MIR548B Gene

Gene Families for MIR548B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR548B: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR548B Gene

Function for MIR548B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR548B Gene

Localization for MIR548B Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR548B Gene

Pathways for MIR548B Gene

SuperPathways for MIR548B Gene

No Data Available

Interacting Proteins for MIR548B Gene

Gene Ontology (GO) - Biological Process for MIR548B Gene

None

No data available for Pathways by source for MIR548B Gene

Transcripts for MIR548B Gene

mRNA/cDNA for MIR548B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548B Gene

No ASD Table

Relevant External Links for MIR548B Gene

GeneLoc Exon Structure for
MIR548B
ECgene alternative splicing isoforms for
MIR548B

Expression for MIR548B Gene

mRNA expression in normal human tissues for MIR548B Gene

genes like me logo Genes that share expressions with MIR548B: view

Orthologs for MIR548B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-548b 37
  • 98 (a)
OneToOne
Species with no ortholog for MIR548B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548B Gene

ENSEMBL:
Gene Tree for MIR548B (if available)
TreeFam:
Gene Tree for MIR548B (if available)

Paralogs for MIR548B Gene

No data available for Paralogs for MIR548B Gene

Variants for MIR548B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR548B Gene

Variant ID Type Subtype PubMed ID
nsv528632 CNV Loss 19592680

Relevant External Links for MIR548B Gene

HapMap Linkage Disequilibrium report
MIR548B

No data available for Sequence variations from dbSNP and Humsavar for MIR548B Gene

Disorders for MIR548B Gene

No disorders were found for MIR548B Gene.

No data available for UniProtKB/Swiss-Prot for MIR548B Gene

Publications for MIR548B Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. (PMID: 24832599) Wang Y. … Cai H. (Cell Death Dis 2014) 3

Products for MIR548B Gene

Sources for MIR548B Gene

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