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Aliases for MIR548B Gene

Subcategory (RNA class) for MIR548B Gene


Quality Score for this RNA gene is


Aliases for MIR548B Gene

  • MicroRNA 548b 2 3 5
  • Hsa-Mir-548b 3
  • MIRN548B 3

External Ids for MIR548B Gene

Previous HGNC Symbols for MIR548B Gene

  • MIRN548B

Previous GeneCards Identifiers for MIR548B Gene

  • GC06M119432
  • GC20M050018

Summaries for MIR548B Gene

Entrez Gene Summary for MIR548B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548B Gene

MIR548B (MicroRNA 548b) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR548B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR548B Gene

Genomics for MIR548B Gene

Regulatory Elements for MIR548B Gene

Enhancers for MIR548B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F119128 1.2 Ensembl ENCODE 10.7 -61.0 -60953 2.2 MLX ARID4B ZNF143 FOS SP5 REST PPARG KAT8 MIER3 SMARCA4 MAN1A1 MIR548B FAM184A
GH06F119026 0.8 ENCODE 10.9 +42.1 42133 0.2 TBP SAP130 CREB3L1 CEBPG YY1 GATA3 ZFHX2 POLR2A NR2F6 KLF6 MIR548B ENSG00000222649 GC06M118991
GH06F119095 0.6 Ensembl ENCODE 11.7 -27.7 -27700 2.0 CEBPB FAM184A MIR548B
GH06F118998 0.5 ENCODE 11 +69.7 69667 1.1 POLR2H ESRRA PRDM1 FAM184A MIR548B GC06M118991 ENSG00000222649
GH06F118965 0.5 ENCODE 10.9 +103.1 103120 0.9 SCRT1 SCRT2 EGR2 YY1 MIR548B ASF1A GC06M118991 MCM9
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR548B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR548B Gene

119,069,047 bp from pter
119,069,143 bp from pter
97 bases
Minus strand

Genomic View for MIR548B Gene

Genes around MIR548B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548B Gene

ORGUL Member Location for MIR548B Gene

ORGUL Member Location for MIR548B gene

Proteins for MIR548B Gene

Post-translational modifications for MIR548B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548B Gene

Domains & Families for MIR548B Gene

Gene Families for MIR548B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR548B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548B Gene

Function for MIR548B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548B Gene

Localization for MIR548B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548B Gene

Pathways & Interactions for MIR548B Gene

SuperPathways for MIR548B Gene

No Data Available

Interacting Proteins for MIR548B Gene

Gene Ontology (GO) - Biological Process for MIR548B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR548B Gene

Transcripts for MIR548B Gene

mRNA/cDNA for MIR548B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548B Gene

No ASD Table

Relevant External Links for MIR548B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR548B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548B Gene:

genes like me logo Genes that share expression patterns with MIR548B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR548B Gene

Orthologs for MIR548B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-548b 35
  • 98 (a)
Species where no ortholog for MIR548B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548B Gene

Gene Tree for MIR548B (if available)
Gene Tree for MIR548B (if available)

Paralogs for MIR548B Gene

No data available for Paralogs for MIR548B Gene

Variants for MIR548B Gene

Sequence variations from dbSNP and Humsavar for MIR548B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080387 -- 119,070,041(+) ATTAA(A/G)TGAGG intron-variant, upstream-variant-2KB
rs113346094 -- 119,069,337(+) CTAGG(C/T)GAAAC intron-variant, upstream-variant-2KB
rs115714110 -- 119,070,938(+) AATTG(A/T)AAGGG intron-variant, upstream-variant-2KB
rs116650349 -- 119,069,550(+) TGCGA(C/T)ACTTC intron-variant, upstream-variant-2KB
rs138033408 -- 119,069,843(+) ATTTC(A/G)CATAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR548B Gene

Variant ID Type Subtype PubMed ID
nsv528632 CNV loss 19592680

Relevant External Links for MIR548B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548B Gene

Disorders for MIR548B Gene

Relevant External Links for MIR548B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR548B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548B Gene

Publications for MIR548B Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. (PMID: 24832599) Wang Y. … Cai H. (Cell Death Dis 2014) 3 64
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR548B Gene

Sources for MIR548B Gene

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