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Aliases for MIR548AC Gene

Subcategory (RNA class) for MIR548AC Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR548AC Gene

  • MicroRNA 548ac 2 3 5
  • Hsa-Mir-548ac 3

External Ids for MIR548AC Gene

Previous GeneCards Identifiers for MIR548AC Gene

  • GC01U903272
  • GC01M117104

Summaries for MIR548AC Gene

Entrez Gene Summary for MIR548AC Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548AC Gene

MIR548AC (MicroRNA 548ac) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548AC Gene

Genomics for MIR548AC Gene

Regulatory Elements for MIR548AC Gene

Enhancers for MIR548AC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F116555 1.4 FANTOM5 Ensembl ENCODE 0.8 +2.0 1957 6.3 HDGF PKNOX1 WRNIP1 BRCA1 ZNF2 ZNF121 ZNF143 ZNF207 FOS JUNB CD58 ATP1A1 CD2 ATP1A1-AS1 CD101 MIR548AC GC01P116556
GH01F116562 0.5 ENCODE 0.8 -2.4 -2396 0.3 WRNIP1 NBN ZBTB33 MLLT1 CHAMP1 IGSF3 MIR320B1 MIR548AC CD58
GH01F116566 0.4 Ensembl 0.4 -6.4 -6390 0.2 ZNF548 IGSF3 MIR320B1 CD58 MIR548AC
GH01F116569 1.1 FANTOM5 ENCODE 0.4 -10.6 -10618 3.1 HDGF PKNOX1 WRNIP1 SIN3A DMAP1 YY1 ZNF143 KLF13 ZNF263 SP3 MAN1A2 CD58 ATP1A1-AS1 ATP1A1 IGSF3 CD101 TTF2 MIR548AC
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR548AC on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR548AC Gene

Chromosome:
1
Start:
116,560,024 bp from pter
End:
116,560,111 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR548AC Gene

Genes around MIR548AC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548AC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548AC Gene

ORGUL Member Location for MIR548AC Gene

ORGUL Member Location for MIR548AC gene

Proteins for MIR548AC Gene

Post-translational modifications for MIR548AC Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548AC Gene

Domains & Families for MIR548AC Gene

Gene Families for MIR548AC Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR548AC: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548AC Gene

Function for MIR548AC Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548AC Gene

Localization for MIR548AC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548AC Gene

Pathways & Interactions for MIR548AC Gene

SuperPathways for MIR548AC Gene

No Data Available

Interacting Proteins for MIR548AC Gene

Gene Ontology (GO) - Biological Process for MIR548AC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR548AC Gene

Transcripts for MIR548AC Gene

mRNA/cDNA for MIR548AC Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548AC Gene

No ASD Table

Relevant External Links for MIR548AC Gene

GeneLoc Exon Structure for
MIR548AC
ECgene alternative splicing isoforms for
MIR548AC

Expression for MIR548AC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548AC Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548AC Gene:

MIR548AC
genes like me logo Genes that share expression patterns with MIR548AC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR548AC Gene

Orthologs for MIR548AC Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548AC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR548AC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548AC Gene

ENSEMBL:
Gene Tree for MIR548AC (if available)
TreeFam:
Gene Tree for MIR548AC (if available)

Paralogs for MIR548AC Gene

No data available for Paralogs for MIR548AC Gene

Variants for MIR548AC Gene

Sequence variations from dbSNP and Humsavar for MIR548AC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112076249 -- 116,560,457(+) TTCTA(G/T)ATACT intron-variant, upstream-variant-2KB
rs12091887 -- 116,561,761(+) agttc(A/G)ctctg intron-variant, upstream-variant-2KB
rs138336347 -- 116,561,267(+) AGCAA(C/T)GAATA intron-variant, upstream-variant-2KB
rs138825502 -- 116,560,925(+) GAGAT(C/T)TGTCA intron-variant, upstream-variant-2KB
rs140397128 -- 116,560,164(+) TTATT(A/G)AAATT intron-variant, upstream-variant-2KB

Relevant External Links for MIR548AC Gene

Human Gene Mutation Database (HGMD)
MIR548AC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548AC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR548AC Gene

Disorders for MIR548AC Gene

Relevant External Links for MIR548AC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR548AC

No disorders were found for MIR548AC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548AC Gene

Publications for MIR548AC Gene

  1. Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis. (PMID: 25795118) Hecker M. … Zettl U.K. (Mutat Res Rev Mutat Res 2015) 3 64
  2. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos N.A. … de Bakker P.I. (Ann. Neurol. 2011) 3 64
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 64
  4. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PMID: 19525953) De Jager P.L. … Oksenberg J.R. (Nat. Genet. 2009) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR548AC Gene

Sources for MIR548AC Gene

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