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Aliases for MIR548AA2 Gene

Subcategory (RNA class) for MIR548AA2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR548AA2 Gene

  • MicroRNA 548aa-2 2 3 5
  • Hsa-Mir-548aa-2 3

External Ids for MIR548AA2 Gene

Previous GeneCards Identifiers for MIR548AA2 Gene

  • GC17U901559
  • GC17P065471

Summaries for MIR548AA2 Gene

Entrez Gene Summary for MIR548AA2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548AA2 Gene

MIR548AA2 (MicroRNA 548aa-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR548AA2 Gene

Genomics for MIR548AA2 Gene

Regulatory Elements for MIR548AA2 Gene

Enhancers for MIR548AA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G067438 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13 -29.7 -29712 6.4 PKNOX1 FOXA2 MLX ZFP64 SIN3A ARID4B ZNF48 ZNF121 FOS ZNF202 NOL11 HELZ LOC100418928 MIR548AA2 MIR548D2 PITPNC1 ENSG00000267731 SLC16A6 BPTF RN7SL756P
GH17G067418 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -49.0 -48995 7.3 TBP SIN3A BRCA1 RAD21 ZBTB40 RFX5 YY1 ZNF121 GATA2 ZNF366 PITPNC1 PSMD12 MIR548AA2 MIR548D2 HELZ BPTF ENSG00000201547 RN7SL756P
GH17G067399 1.4 Ensembl ENCODE dbSUPER 12 -69.7 -69703 4.2 HDGF NFIB FEZF1 ZBTB7B YY1 SCRT2 FOS RCOR1 CEBPB ZNF843 PSMD12 MIR548AA2 MIR548D2 PITPNC1 ENSG00000201547 GC17P067379 GC17P067378
GH17G067398 0.9 FANTOM5 dbSUPER 12.1 -72.6 -72636 0.4 CTCF PKNOX1 GATA3 CREB1 ZBTB7B RAD21 PITPNC1 PSMD12 MIR548AA2 MIR548D2 HELZ BPTF ENSG00000201547 GC17P067378 GC17P067379
GH17G067605 0.7 ENCODE 11.4 +135.0 135039 2.0 CTCF TFAP4 ESRRA NFIB RAD21 ZNF7 ZNF664 GATA3 POLR2A GATA2 PITPNC1 PSMD12 MIR548D2 MIR548AA2 ENSG00000279917 GC17P067605
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR548AA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR548AA2 Gene

Chromosome:
17
Start:
67,471,489 bp from pter
End:
67,471,585 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR548AA2 Gene

Genes around MIR548AA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548AA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548AA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548AA2 Gene

Proteins for MIR548AA2 Gene

Post-translational modifications for MIR548AA2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548AA2 Gene

Domains & Families for MIR548AA2 Gene

Gene Families for MIR548AA2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR548AA2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR548AA2 Gene

Function for MIR548AA2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548AA2 Gene

Localization for MIR548AA2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR548AA2 Gene

Pathways & Interactions for MIR548AA2 Gene

SuperPathways for MIR548AA2 Gene

No Data Available

Interacting Proteins for MIR548AA2 Gene

Gene Ontology (GO) - Biological Process for MIR548AA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR548AA2 Gene

Drugs & Compounds for MIR548AA2 Gene

No Compound Related Data Available

Transcripts for MIR548AA2 Gene

mRNA/cDNA for MIR548AA2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548AA2 Gene

No ASD Table

Relevant External Links for MIR548AA2 Gene

GeneLoc Exon Structure for
MIR548AA2
ECgene alternative splicing isoforms for
MIR548AA2

Expression for MIR548AA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548AA2 Gene:

MIR548AA2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548AA2 Gene

Orthologs for MIR548AA2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548AA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 68 (a)
ManyToMany
Species where no ortholog for MIR548AA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548AA2 Gene

ENSEMBL:
Gene Tree for MIR548AA2 (if available)
TreeFam:
Gene Tree for MIR548AA2 (if available)

Paralogs for MIR548AA2 Gene

No data available for Paralogs for MIR548AA2 Gene

Variants for MIR548AA2 Gene

Sequence variations from dbSNP and Humsavar for MIR548AA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000390751 -- 67,471,046(+) AAGTA(A/C)TCAGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003527776 -- 67,471,671(+) TTTAG(A/T)TTTAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1006601006 -- 67,471,874(+) AATCA(A/G)GATAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1006667017 -- 67,469,711(+) CTGCT(A/C)TGGTG intron-variant, upstream-variant-2KB
rs1007711356 -- 67,470,699(+) GGGAG(A/G)TGTAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR548AA2 Gene

Variant ID Type Subtype PubMed ID
nsv1120054 OTHER inversion 24896259
nsv471703 CNV gain 15918152
nsv833522 CNV gain+loss 17160897

Relevant External Links for MIR548AA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548AA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548AA2 Gene

Disorders for MIR548AA2 Gene

Relevant External Links for MIR548AA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR548AA2

No disorders were found for MIR548AA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548AA2 Gene

Publications for MIR548AA2 Gene

  1. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D. … Lui W.O. (BMC Biol. 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR548AA2 Gene

Sources for MIR548AA2 Gene

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