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Aliases for MIR545 Gene

Subcategory (RNA class) for MIR545 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR545 Gene

  • MicroRNA 545 2 3 5
  • Hsa-Mir-545 3
  • Mir-545 3
  • MIRN545 3

External Ids for MIR545 Gene

Previous HGNC Symbols for MIR545 Gene

  • MIRN545

Previous GeneCards Identifiers for MIR545 Gene

  • GC0XM073426
  • GC0XM073506

Summaries for MIR545 Gene

Entrez Gene Summary for MIR545 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR545 Gene

MIR545 (MicroRNA 545) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR545 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR545 Gene

Genomics for MIR545 Gene

Regulatory Elements for MIR545 Gene

Enhancers for MIR545 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH074248 1.1 Ensembl ENCODE 12.9 +36.6 36607 4 HDAC1 ELF3 FOXA2 FEZF1 ZBTB40 TCF12 ZNF121 ZSCAN5C FOS ZEB2 MIR374B MIR421 MIR374A MIR545 FTX JPX GC0XP074249 ENSG00000278421
GH0XH074240 1.1 Ensembl ENCODE 12.1 +44.8 44783 2 ELF3 FOXA2 THRB RARA CREM MIXL1 PPARG NFIL3 CEBPA ETV4 MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX RN7SL648P GC0XP074233
GH0XH074550 0.9 ENCODE 11.7 -263.3 -263252 0 RB1 ZSCAN4 INSM2 ZNF76 KLF17 ZNF2 RAD21 GTF3C2 ZNF121 ZNF143 RAB11FIP1P1 RN7SL648P FTX MIR545 MIR374A PIR45746 PIR50185
GH0XH074262 0.5 ENCODE 13.7 +24.3 24304 1 FOXA2 GLIS1 POU5F1 ZBTB40 FOXA1 MIR545 MIR374A FTX ENSG00000278421 GC0XP074249
GH0XH074259 0.4 ENCODE 13.7 +27.0 26964 1 MAX POU5F1 MIR374A MIR545 FTX JPX ENSG00000278421 GC0XP074249
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR545 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR545 Gene

Chromosome:
X
Start:
74,287,104 bp from pter
End:
74,287,209 bp from pter
Size:
106 bases
Orientation:
Minus strand

Genomic View for MIR545 Gene

Genes around MIR545 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR545 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR545 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR545 Gene

Proteins for MIR545 Gene

Post-translational modifications for MIR545 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR545 Gene

Domains & Families for MIR545 Gene

Gene Families for MIR545 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR545: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR545 Gene

Function for MIR545 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR545
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR545 Gene

Localization for MIR545 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR545 Gene

Pathways & Interactions for MIR545 Gene

SuperPathways for MIR545 Gene

No Data Available

Interacting Proteins for MIR545 Gene

Gene Ontology (GO) - Biological Process for MIR545 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR545 Gene

Drugs & Compounds for MIR545 Gene

No Compound Related Data Available

Transcripts for MIR545 Gene

mRNA/cDNA for MIR545 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR545
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR545 Gene

No ASD Table

Relevant External Links for MIR545 Gene

GeneLoc Exon Structure for
MIR545
ECgene alternative splicing isoforms for
MIR545

Expression for MIR545 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR545 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR545 Gene:

MIR545
genes like me logo Genes that share expression patterns with MIR545: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR545 Gene

Orthologs for MIR545 Gene

Evolution for MIR545 Gene

ENSEMBL:
Gene Tree for MIR545 (if available)
TreeFam:
Gene Tree for MIR545 (if available)

No data available for Orthologs for MIR545 Gene

Paralogs for MIR545 Gene

No data available for Paralogs for MIR545 Gene

Variants for MIR545 Gene

Sequence variations from dbSNP and Humsavar for MIR545 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1001568529 -- 74,286,852(+) CAAAG(C/T)CCTAT intron-variant, downstream-variant-500B
rs1003229089 -- 74,288,749(+) CACTT(C/T)GGGAG intron-variant, upstream-variant-2KB
rs1006167313 -- 74,286,615(+) CAGGA(A/G)TTCAA intron-variant, downstream-variant-500B
rs1007372455 -- 74,287,096(+) TGACA(A/G)TCCAG intron-variant, downstream-variant-500B
rs1010622740 -- 74,288,032(+) ACTCT(A/G)CCCAC intron-variant, upstream-variant-2KB

Relevant External Links for MIR545 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR545

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR545 Gene

Disorders for MIR545 Gene

Relevant External Links for MIR545

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR545

No disorders were found for MIR545 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR545 Gene

Publications for MIR545 Gene

  1. The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2. (PMID: 25537514) Gu Y … Guo Z (Oncotarget 2015) 3 60
  2. miR-545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG-I. (PMID: 25315416) Song B … Jin G (FEBS letters 2014) 3 60
  3. The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. (PMID: 25299640) Zhao Q … Qin C (PloS one 2014) 3 60
  4. MicroRNA-545 suppresses cell proliferation by targeting cyclin D1 and CDK4 in lung cancer cells. (PMID: 24505359) Du B … Zhang B (PloS one 2014) 3 60
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60

Products for MIR545 Gene

Sources for MIR545 Gene

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