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Aliases for MIR545 Gene

Subcategory (RNA class) for MIR545 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR545 Gene

  • MicroRNA 545 2 3 5
  • Hsa-Mir-545 3
  • Mir-545 3
  • MIRN545 3

External Ids for MIR545 Gene

Previous HGNC Symbols for MIR545 Gene

  • MIRN545

Previous GeneCards Identifiers for MIR545 Gene

  • GC0XM073426
  • GC0XM073506

Summaries for MIR545 Gene

Entrez Gene Summary for MIR545 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR545 Gene

MIR545 (MicroRNA 545) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR545 Gene

Genomics for MIR545 Gene

Regulatory Elements for MIR545 Gene


Promoters for MIR545 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR545 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR545 Gene

Chromosome:
X
Start:
74,287,104 bp from pter
End:
74,287,209 bp from pter
Size:
106 bases
Orientation:
Minus strand

Genomic View for MIR545 Gene

Genes around MIR545 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR545 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR545 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR545 Gene

Proteins for MIR545 Gene

Post-translational modifications for MIR545 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR545 Gene

Domains & Families for MIR545 Gene

Gene Families for MIR545 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR545: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR545 Gene

Function for MIR545 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR545 Gene

Localization for MIR545 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR545 Gene

Pathways & Interactions for MIR545 Gene

SuperPathways for MIR545 Gene

No Data Available

Interacting Proteins for MIR545 Gene

Gene Ontology (GO) - Biological Process for MIR545 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR545 Gene

Drugs & Compounds for MIR545 Gene

No Compound Related Data Available

Transcripts for MIR545 Gene

mRNA/cDNA for MIR545 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR545 Gene

No ASD Table

Relevant External Links for MIR545 Gene

GeneLoc Exon Structure for
MIR545
ECgene alternative splicing isoforms for
MIR545

Expression for MIR545 Gene

mRNA expression in normal human tissues for MIR545 Gene

genes like me logo Genes that share expression patterns with MIR545: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR545 Gene

Orthologs for MIR545 Gene

Evolution for MIR545 Gene

ENSEMBL:
Gene Tree for MIR545 (if available)
TreeFam:
Gene Tree for MIR545 (if available)

No data available for Orthologs for MIR545 Gene

Paralogs for MIR545 Gene

No data available for Paralogs for MIR545 Gene

Variants for MIR545 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR545 Gene

Disorders for MIR545 Gene

Relevant External Links for MIR545

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR545

No disorders were found for MIR545 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR545 Gene

Publications for MIR545 Gene

  1. The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2. (PMID: 25537514) Gu Y. … Guo Z. (Oncotarget 2015) 3 67
  2. MicroRNA-545 suppresses cell proliferation by targeting cyclin D1 and CDK4 in lung cancer cells. (PMID: 24505359) Du B. … Zhang B. (PLoS ONE 2014) 3
  3. The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. (PMID: 25299640) Zhao Q. … Qin C. (PLoS ONE 2014) 3
  4. miR-545 inhibited Pancreatic ductal adenocarcinoma growth by targeting RIG-I. (PMID: 25315416) Song B. … Jin G. (FEBS Lett. 2014) 3
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3

Products for MIR545 Gene

Sources for MIR545 Gene

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