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Aliases for MIR545 Gene

Subcategory (RNA class) for MIR545 Gene


Quality Score for this RNA gene is


Aliases for MIR545 Gene

  • MicroRNA 545 2 3 5
  • Hsa-Mir-545 3
  • Mir-545 3
  • MIRN545 3

External Ids for MIR545 Gene

Previous HGNC Symbols for MIR545 Gene

  • MIRN545

Previous GeneCards Identifiers for MIR545 Gene

  • GC0XM073426
  • GC0XM073506

Summaries for MIR545 Gene

Entrez Gene Summary for MIR545 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR545 Gene

MIR545 (MicroRNA 545) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR545 Gene

Genomics for MIR545 Gene

Regulatory Elements for MIR545 Gene

Enhancers for MIR545 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF074259 0.8 ENCODE 13.7 +27.0 26964 1.4 MAX POU5F1 MIR374A MIR545 FTX JPX ENSG00000271430 ENSG00000278421 GC0XP074249
GH0XF074262 0.2 ENCODE 13.7 +24.3 24304 1.5 JUND GLIS1 POU5F1 ZBTB40 MIR374A MIR545 FTX ENSG00000278421 GC0XP074249
GH0XF074248 1.2 Ensembl ENCODE 12.9 +36.5 36546 5.1 ELF3 FEZF1 ZBTB40 ZNF121 ZEB2 ZNF843 SMARCA4 CEBPA GLIS1 KDM1A MIR374B MIR421 MIR374A MIR545 FTX JPX ENSG00000271430 GC0XP074249 ENSG00000278421
GH0XF074240 0.9 Ensembl ENCODE 12.1 +44.8 44783 3.0 ELF3 THRB RARA CREM MIXL1 ZNF263 PPARG CEBPA ETV4 SOX13 MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX ENSG00000271430 RN7SL648P
GH0XF074550 0.9 ENCODE 11.7 -263.3 -263252 0.2 INSM2 ZNF76 KLF17 ZNF2 RAD21 GTF3C2 ZNF121 ZNF143 ZNF391 CREM RAB11FIP1P1 ENSG00000271430 RN7SL648P FTX MIR374A MIR545 PIR45746 PIR50185
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR545 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR545 Gene

74,287,104 bp from pter
74,287,209 bp from pter
106 bases
Minus strand

Genomic View for MIR545 Gene

Genes around MIR545 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR545 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR545 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR545 Gene

Proteins for MIR545 Gene

Post-translational modifications for MIR545 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR545 Gene

Domains & Families for MIR545 Gene

Gene Families for MIR545 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR545: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR545 Gene

Function for MIR545 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR545 Gene

Localization for MIR545 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR545 Gene

Pathways & Interactions for MIR545 Gene

SuperPathways for MIR545 Gene

No Data Available

Interacting Proteins for MIR545 Gene

Gene Ontology (GO) - Biological Process for MIR545 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR545 Gene

Transcripts for MIR545 Gene

mRNA/cDNA for MIR545 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR545 Gene

No ASD Table

Relevant External Links for MIR545 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR545 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR545 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR545 Gene:

genes like me logo Genes that share expression patterns with MIR545: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR545 Gene

Orthologs for MIR545 Gene

Evolution for MIR545 Gene

Gene Tree for MIR545 (if available)
Gene Tree for MIR545 (if available)

No data available for Orthologs for MIR545 Gene

Paralogs for MIR545 Gene

No data available for Paralogs for MIR545 Gene

Variants for MIR545 Gene

Sequence variations from dbSNP and Humsavar for MIR545 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112129167 -- 74,289,021(+) TGAAT(A/G)ATTCA intron-variant, upstream-variant-2KB
rs113373338 -- 74,286,648(+) AGACC(C/G)CTTCT intron-variant, downstream-variant-500B
rs139107933 -- 74,289,001(+) AATAA(C/T)ATTCA intron-variant, upstream-variant-2KB
rs141329807 -- 74,286,870(+) TACTA(A/T)TTGGA intron-variant, downstream-variant-500B
rs174145 -- 74,288,955(+) ATATT(A/G)CTGGG intron-variant, upstream-variant-2KB

Relevant External Links for MIR545 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR545 Gene

Disorders for MIR545 Gene

Relevant External Links for MIR545

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR545 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR545 Gene

Publications for MIR545 Gene

  1. The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2. (PMID: 25537514) Gu Y. … Guo Z. (Oncotarget 2015) 3 64
  2. MicroRNA-545 suppresses cell proliferation by targeting cyclin D1 and CDK4 in lung cancer cells. (PMID: 24505359) Du B. … Zhang B. (PLoS ONE 2014) 3 64
  3. The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. (PMID: 25299640) Zhao Q. … Qin C. (PLoS ONE 2014) 3 64
  4. miR-545 inhibited Pancreatic ductal adenocarcinoma growth by targeting RIG-I. (PMID: 25315416) Song B. … Jin G. (FEBS Lett. 2014) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR545 Gene

Sources for MIR545 Gene

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