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Aliases for MIR543 Gene

Subcategory (RNA class) for MIR543 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR543 Gene

  • MicroRNA 543 2 3 5
  • Hsa-Mir-543 3
  • Mir-543 3
  • MIRN543 3

External Ids for MIR543 Gene

ORGUL Members for MIR543 Gene

Previous HGNC Symbols for MIR543 Gene

  • MIRN543

Previous GeneCards Identifiers for MIR543 Gene

  • GC14U900894
  • GC14P100935
  • GC14P101498
  • GC14P101083
  • GC14P101353
  • GC14P102031
  • GC14P102278
  • GC14P102450
  • GC14P102625

Summaries for MIR543 Gene

Entrez Gene Summary for MIR543 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR543 Gene

MIR543 (MicroRNA 543) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR543 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR543 Gene

Genomics for MIR543 Gene

Regulatory Elements for MIR543 Gene

Enhancers for MIR543 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H101215 0.8 ENCODE 10.4 +184.7 184738 2.8 SOX13 TFAP4 FOXA2 SAP130 ARID4B CEBPG RAD21 ZNF644 ZSCAN9 RARA SNORD113-3 SNORD113-8 SNORD113-9 SNORD113-6 SNORD113-7 SNORD113-4 MIR543 ENSG00000222185 ENSG00000222095 SNORD114-31
GH14H101096 0.8 FANTOM5 ENCODE 10.2 +66.4 66361 3.2 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR543 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR543 Gene

Genomic Locations for MIR543 Gene
chr14:101,031,987-101,032,064
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand
chr14:101,498,324-101,498,401
(GRCh37/hg19)

Genomic View for MIR543 Gene

Genes around MIR543 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR543 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR543 Gene

Proteins for MIR543 Gene

Post-translational modifications for MIR543 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR543 Gene

Domains & Families for MIR543 Gene

Gene Families for MIR543 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR543: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR543 Gene

Function for MIR543 Gene

Gene Ontology (GO) - Molecular Function for MIR543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25465621
genes like me logo Genes that share ontologies with MIR543: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR543 Gene

Localization for MIR543 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR543 Gene

Pathways & Interactions for MIR543 Gene

SuperPathways for MIR543 Gene

No Data Available

Interacting Proteins for MIR543 Gene

Gene Ontology (GO) - Biological Process for MIR543 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 25465621
GO:2000773 negative regulation of cellular senescence IDA 25465621
genes like me logo Genes that share ontologies with MIR543: view

No data available for Pathways by source and SIGNOR curated interactions for MIR543 Gene

Drugs & Compounds for MIR543 Gene

No Compound Related Data Available

Transcripts for MIR543 Gene

mRNA/cDNA for MIR543 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR543 Gene

No ASD Table

Relevant External Links for MIR543 Gene

GeneLoc Exon Structure for
MIR543
ECgene alternative splicing isoforms for
MIR543

Expression for MIR543 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR543 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR543 Gene:

MIR543
genes like me logo Genes that share expression patterns with MIR543: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR543 Gene

Orthologs for MIR543 Gene

Evolution for MIR543 Gene

ENSEMBL:
Gene Tree for MIR543 (if available)
TreeFam:
Gene Tree for MIR543 (if available)

No data available for Orthologs for MIR543 Gene

Paralogs for MIR543 Gene

No data available for Paralogs for MIR543 Gene

Variants for MIR543 Gene

Sequence variations from dbSNP and Humsavar for MIR543 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000647555 -- 101,032,212(+) TTTTT(C/T)ATGAA downstream-variant-500B, upstream-variant-2KB
rs1000703711 -- 101,032,505(+) TCCCA(C/T)AGCCG downstream-variant-500B, upstream-variant-2KB
rs1003551662 -- 101,030,769(+) CCAGC(C/T)GCTTC upstream-variant-2KB
rs1003702098 -- 101,031,099(+) AGTTG(A/G)GACCC upstream-variant-2KB
rs1005175224 -- 101,031,834(+) CCTGT(C/T)AGATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR543 Gene

Variant ID Type Subtype PubMed ID
nsv565860 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv1426 CNV insertion 18451855
nsv1040993 CNV gain 25217958
esv3635523 CNV gain 21293372
esv3635521 CNV gain 21293372

Relevant External Links for MIR543 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR543

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR543 Gene

Disorders for MIR543 Gene

Relevant External Links for MIR543

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR543

No disorders were found for MIR543 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR543 Gene

Publications for MIR543 Gene

  1. MicroRNA-543 acts as a prognostic marker and promotes the cell proliferation in cervical cancer by BRCA1-interacting protein 1. (PMID: 28231728) Dang H … Wu X (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP. (PMID: 28245474) Du Y … Xiao CC (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  3. miR-543 promotes gastric cancer cell proliferation by targeting SIRT1. (PMID: 26612257) Li J … Yang Q (Biochemical and biophysical research communications 2016) 3 60
  4. miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog. (PMID: 27769862) Bi M … Tang C (Biochemical and biophysical research communications 2016) 3 60
  5. Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7. (PMID: 26402225) Song N … Zhang S (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015) 3 60

Products for MIR543 Gene

Sources for MIR543 Gene

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