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Aliases for MIR543 Gene

Subcategory (RNA class) for MIR543 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR543 Gene

  • MicroRNA 543 2 3 5
  • Hsa-Mir-543 3
  • Mir-543 3
  • MIRN543 3

External Ids for MIR543 Gene

ORGUL Members for MIR543 Gene

Previous HGNC Symbols for MIR543 Gene

  • MIRN543

Previous GeneCards Identifiers for MIR543 Gene

  • GC14U900894
  • GC14P100935
  • GC14P101498
  • GC14P101083
  • GC14P101353
  • GC14P102031
  • GC14P102278

Summaries for MIR543 Gene

Entrez Gene Summary for MIR543 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR543 Gene

MIR543 (MicroRNA 543) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR543 Gene

Genomics for MIR543 Gene

Regulatory Elements for MIR543 Gene

Enhancers for MIR543 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F101096 1.1 FANTOM5 ENCODE 10.2 +66.4 66361 3.2 CTCF SUZ12 JUN ZIC2 ZNF335 GLIS2 ZNF366 POLR2A SCRT2 PATZ1 RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14F101215 1 ENCODE 10.4 +184.7 184738 2.8 HDGF ARID4B ZNF48 GATA2 SSRP1 ZNF658 ETV4 HNF4A KDM1A ZNF785 MIR6764 SNORD113-4 SNORD113-3 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9 MIR543 ENSG00000222185 ENSG00000222095
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR543 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR543 Gene

Chromosome:
14
Start:
101,031,987 bp from pter
End:
101,032,064 bp from pter
Size:
78 bases
Orientation:
Plus strand

Genomic View for MIR543 Gene

Genes around MIR543 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR543 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR543 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR543 Gene

Proteins for MIR543 Gene

Post-translational modifications for MIR543 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR543 Gene

Domains & Families for MIR543 Gene

Gene Families for MIR543 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR543: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR543 Gene

Function for MIR543 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR543 Gene

Localization for MIR543 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR543 Gene

Pathways & Interactions for MIR543 Gene

SuperPathways for MIR543 Gene

No Data Available

Interacting Proteins for MIR543 Gene

Gene Ontology (GO) - Biological Process for MIR543 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR543 Gene

Transcripts for MIR543 Gene

mRNA/cDNA for MIR543 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR543 Gene

No ASD Table

Relevant External Links for MIR543 Gene

GeneLoc Exon Structure for
MIR543
ECgene alternative splicing isoforms for
MIR543

Expression for MIR543 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR543 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR543 Gene:

MIR543
genes like me logo Genes that share expression patterns with MIR543: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR543 Gene

Orthologs for MIR543 Gene

Evolution for MIR543 Gene

ENSEMBL:
Gene Tree for MIR543 (if available)
TreeFam:
Gene Tree for MIR543 (if available)

No data available for Orthologs for MIR543 Gene

Paralogs for MIR543 Gene

No data available for Paralogs for MIR543 Gene

Variants for MIR543 Gene

Sequence variations from dbSNP and Humsavar for MIR543 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs113293370 -- 101,031,791(+) AAGCA(A/G)CTCCA upstream-variant-2KB
rs114067893 -- 101,031,026(+) TGGTC(C/T)GTTCA upstream-variant-2KB
rs11628379 -- 101,032,222(+) AAGCT(C/T)CCGTC downstream-variant-500B, upstream-variant-2KB
rs117345379 -- 101,032,166(+) TCTTT(C/T)CTCCT downstream-variant-500B, upstream-variant-2KB
rs117856308 -- 101,031,250(+) ACGGC(C/T)GAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR543 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR543 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR543

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR543 Gene

Disorders for MIR543 Gene

Relevant External Links for MIR543

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR543

No disorders were found for MIR543 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR543 Gene

Publications for MIR543 Gene

  1. miR-543 promotes gastric cancer cell proliferation by targeting SIRT1. (PMID: 26612257) Li J. … Yang Q. (Biochem. Biophys. Res. Commun. 2016) 3 64
  2. Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1. (PMID: 26562529) Hu X. … Tian H. (Biochem. Biophys. Res. Commun. 2015) 3 64
  3. Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7. (PMID: 26402225) Song N. … Zhang S. (Cell. Physiol. Biochem. 2015) 3 64
  4. miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18. (PMID: 25465621) Lee S. … Kang K.S. (Age (Dordr) 2014) 3 64
  5. MicroRNA expression analysis of mammospheres cultured from human breast cancers. (PMID: 22752669) Feifei N. … Fengchun Z. (J. Cancer Res. Clin. Oncol. 2012) 3 64

Products for MIR543 Gene

Sources for MIR543 Gene

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