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Aliases for MIR526A2 Gene

Subcategory (RNA class) for MIR526A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR526A2 Gene

  • MicroRNA 526a-2 2 3 5
  • Hsa-Mir-526a-2 3
  • MIRN526A-2 3
  • MIRN526A2 3

External Ids for MIR526A2 Gene

ORGUL Members for MIR526A2 Gene

Previous HGNC Symbols for MIR526A2 Gene

  • MIRN526A-2
  • MIRN526A2

Previous GeneCards Identifiers for MIR526A2 Gene

  • GC19P058955
  • GC19P059011
  • GC19P054232
  • GC19P054253
  • GC19P054304
  • GC19P054330
  • GC19P054350
  • GC19P054424
  • GC19P054503

Summaries for MIR526A2 Gene

Entrez Gene Summary for MIR526A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR526A2 Gene

MIR526A2 (MicroRNA 526a-2) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR526A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR526A2 Gene

Genomics for MIR526A2 Gene

Regulatory Elements for MIR526A2 Gene

Enhancers for MIR526A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H053840 1.2 Ensembl ENCODE 10.5 +115.2 115207 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19H053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +118.2 118172 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19H053659 1 ENCODE dbSUPER 11 -65.6 -65647 2.7 ELF3 SOX5 SOX13 GATAD2A SAP130 SP5 PPARG ETV4 CREB1 POU5F1 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19H053611 1 ENCODE dbSUPER 10.8 -114.0 -113957 3.1 SOX13 ESRRA FOXA2 TEAD3 CTBP1 GATA3 POLR2A NR2F6 SMARCE1 SOX5 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C MIR526A1
GH19H053898 0.9 Ensembl ENCODE 10.6 +171.9 171921 1.3 PKNOX1 MAZ SP3 KLF1 ZNF740 SP2 REST SP1 POLR2A PATZ1 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A MIR516A2 RNU6-1041P MIR519A1 RNU6-751P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR526A2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR526A2 Gene

Genomic Locations for MIR526A2 Gene
chr19:53,726,922-53,726,986
(GRCh38/hg38)
Size:
65 bases
Orientation:
Plus strand
chr19:54,230,176-54,230,240
(GRCh37/hg19)

Genomic View for MIR526A2 Gene

Genes around MIR526A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR526A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR526A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR526A2 Gene

Proteins for MIR526A2 Gene

Post-translational modifications for MIR526A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR526A2 Gene

Domains & Families for MIR526A2 Gene

Gene Families for MIR526A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR526A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR526A2 Gene

Function for MIR526A2 Gene

Gene Ontology (GO) - Molecular Function for MIR526A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24639097
genes like me logo Genes that share ontologies with MIR526A2: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR526A2 Gene

Localization for MIR526A2 Gene

Gene Ontology (GO) - Cellular Components for MIR526A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR526A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR526A2 Gene

Pathways & Interactions for MIR526A2 Gene

SuperPathways for MIR526A2 Gene

No Data Available

Interacting Proteins for MIR526A2 Gene

Gene Ontology (GO) - Biological Process for MIR526A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 24639097
genes like me logo Genes that share ontologies with MIR526A2: view

No data available for Pathways by source and SIGNOR curated interactions for MIR526A2 Gene

Drugs & Compounds for MIR526A2 Gene

No Compound Related Data Available

Transcripts for MIR526A2 Gene

mRNA/cDNA for MIR526A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR526A2 Gene

No ASD Table

Relevant External Links for MIR526A2 Gene

GeneLoc Exon Structure for
MIR526A2
ECgene alternative splicing isoforms for
MIR526A2

Expression for MIR526A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR526A2 Gene:

MIR526A2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR526A2 Gene

Orthologs for MIR526A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR526A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-526a-2 34
  • 91 (a)
OneToOne
Species where no ortholog for MIR526A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR526A2 Gene

ENSEMBL:
Gene Tree for MIR526A2 (if available)
TreeFam:
Gene Tree for MIR526A2 (if available)

Paralogs for MIR526A2 Gene

No data available for Paralogs for MIR526A2 Gene

Variants for MIR526A2 Gene

Sequence variations from dbSNP and Humsavar for MIR526A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001074608 -- 53,726,129(+) TGTCC(C/T)GCCCT upstream-variant-2KB
rs1001105624 -- 53,726,346(+) TGTAT(G/T)TTTAG upstream-variant-2KB
rs1001364425 -- 53,725,145(+) TCTAA(A/G)TTCAT upstream-variant-2KB
rs1003700074 -- 53,726,261(+) CTCCC(A/G)GGTTC upstream-variant-2KB
rs1006789990 -- 53,724,922(+) CTCCT(A/T)AAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR526A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR526A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR526A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR526A2 Gene

Disorders for MIR526A2 Gene

Relevant External Links for MIR526A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR526A2

No disorders were found for MIR526A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR526A2 Gene

Publications for MIR526A2 Gene

  1. miR-526a regulates apoptotic cell growth in human carcinoma cells. (PMID: 26002288) Yang X … Zheng Z (Molecular and cellular biochemistry 2015) 3 60
  2. MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus. (PMID: 24639097) Zhao C … Ling X (Molecular medicine reports 2014) 3 60
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 60
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60
  5. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I … Bentwich Z (Nature genetics 2005) 3 60

Products for MIR526A2 Gene

Sources for MIR526A2 Gene

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