Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR524 Gene

Subcategory (RNA class) for MIR524 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR524 Gene

  • MicroRNA 524 2 3
  • Hsa-Mir-524 3
  • MIRN524 3

External Ids for MIR524 Gene

ORGUL Members for MIR524 Gene

Previous HGNC Symbols for MIR524 Gene

  • MIRN524

Previous GeneCards Identifiers for MIR524 Gene

  • GC19P058939
  • GC19P059003
  • GC19P054214

Summaries for MIR524 Gene

Entrez Gene Summary for MIR524 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR524 Gene

MIR524 (MicroRNA 524) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR524 Gene

Genomics for MIR524 Gene

Genomic Location for MIR524 Gene

Start:
53,711,002 bp from pter
End:
53,711,088 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR524 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR524 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR524 Gene

No data available for Regulatory Elements for MIR524 Gene

Proteins for MIR524 Gene

Post-translational modifications for MIR524 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR524 Gene

Domains for MIR524 Gene

Gene Families for MIR524 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR524: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR524 Gene

Function for MIR524 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR524 Gene

Localization for MIR524 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR524 Gene

Pathways for MIR524 Gene

SuperPathways for MIR524 Gene

No Data Available

Interacting Proteins for MIR524 Gene

Gene Ontology (GO) - Biological Process for MIR524 Gene

None

No data available for Pathways by source for MIR524 Gene

Transcripts for MIR524 Gene

mRNA/cDNA for MIR524 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR524

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR524 Gene

No ASD Table

Relevant External Links for MIR524 Gene

GeneLoc Exon Structure for
MIR524
ECgene alternative splicing isoforms for
MIR524

Expression for MIR524 Gene

mRNA expression in normal human tissues for MIR524 Gene

genes like me logo Genes that share expressions with MIR524: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR524 Gene

Orthologs for MIR524 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR524 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-524 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR524:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR524 Gene

ENSEMBL:
Gene Tree for MIR524 (if available)
TreeFam:
Gene Tree for MIR524 (if available)

Paralogs for MIR524 Gene

No data available for Paralogs for MIR524 Gene

Variants for MIR524 Gene

Sequence variations from dbSNP and Humsavar for MIR524 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2865850 -- 53,709,988(+) atccc(A/T)tctct upstream-variant-2KB
rs11084277 -- 53,709,521(+) cgcaa(A/G)tagct upstream-variant-2KB
rs11084278 -- 53,709,578(+) tagac(A/G)agaaa upstream-variant-2KB
rs11084279 -- 53,709,591(+) gtttc(A/G)ccatg upstream-variant-2KB
rs56010210 -- 53,709,395(+) GCCCA(A/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR524 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718836 CNV Deletion 23290073

Relevant External Links for MIR524 Gene

HapMap Linkage Disequilibrium report
MIR524

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR524 Gene

Disorders for MIR524 Gene

No disorders were found for MIR524 Gene.

No data available for UniProtKB/Swiss-Prot for MIR524 Gene

Publications for MIR524 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. (PMID: 22871495) Chen L. … Kang C. (Carcinogenesis 2012) 3

Products for MIR524 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR524
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR524
    • Block miRNA regulation of MIR524 using miScript Target Protectors

    Sources for MIR524 Gene

    Back to Top

    Content