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Aliases for MIR524 Gene

Subcategory (RNA class) for MIR524 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR524 Gene

  • MicroRNA 524 2 3
  • Hsa-Mir-524 3
  • Mir-524 3
  • MIRN524 3

External Ids for MIR524 Gene

ORGUL Members for MIR524 Gene

Previous HGNC Symbols for MIR524 Gene

  • MIRN524

Previous GeneCards Identifiers for MIR524 Gene

  • GC19P058939
  • GC19P059003
  • GC19P054214
  • GC19P053711

Summaries for MIR524 Gene

Entrez Gene Summary for MIR524 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR524 Gene

MIR524 (MicroRNA 524) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR524 Gene

Genomics for MIR524 Gene

Genomic Location for MIR524 Gene

Chromosome:
19
Start:
53,710,988 bp from pter
End:
53,711,093 bp from pter
Size:
106 bases
Orientation:
Plus strand

Genomic View for MIR524 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR524 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR524 Gene

No data available for Regulatory Elements for MIR524 Gene

Proteins for MIR524 Gene

Post-translational modifications for MIR524 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR524 Gene

Domains & Families for MIR524 Gene

Gene Families for MIR524 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR524: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR524 Gene

Function for MIR524 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR524 Gene

Localization for MIR524 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR524 Gene

Pathways & Interactions for MIR524 Gene

SuperPathways for MIR524 Gene

No Data Available

Interacting Proteins for MIR524 Gene

Gene Ontology (GO) - Biological Process for MIR524 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR524 Gene

Drugs & Compounds for MIR524 Gene

No Compound Related Data Available

Transcripts for MIR524 Gene

mRNA/cDNA for MIR524 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR524 Gene

No ASD Table

Relevant External Links for MIR524 Gene

GeneLoc Exon Structure for
MIR524
ECgene alternative splicing isoforms for
MIR524

Expression for MIR524 Gene

mRNA expression in normal human tissues for MIR524 Gene

genes like me logo Genes that share expression patterns with MIR524: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR524 Gene

Orthologs for MIR524 Gene

Evolution for MIR524 Gene

ENSEMBL:
Gene Tree for MIR524 (if available)
TreeFam:
Gene Tree for MIR524 (if available)

No data available for Orthologs for MIR524 Gene

Paralogs for MIR524 Gene

No data available for Paralogs for MIR524 Gene

Variants for MIR524 Gene

Sequence variations from dbSNP and Humsavar for MIR524 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2865850 -- 53,709,988(+) atccc(A/T)tctct upstream-variant-2KB
rs11084277 -- 53,709,521(+) cgcaa(A/G)tagct upstream-variant-2KB
rs11084278 -- 53,709,578(+) tagac(A/G)agaaa upstream-variant-2KB
rs11084279 -- 53,709,591(+) gtttc(A/G)ccatg upstream-variant-2KB
rs56010210 -- 53,709,395(+) GCCCA(A/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR524 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718836 CNV Deletion 23290073

Relevant External Links for MIR524 Gene

HapMap Linkage Disequilibrium report
MIR524

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR524 Gene

Disorders for MIR524 Gene

Relevant External Links for MIR524

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR524
genes like me logo Genes that share disorders with MIR524: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR524 Gene

Publications for MIR524 Gene

  1. miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2. (PMID: 25275294) Liu S.M. … Ma N. (Oncotarget 2014) 67
  2. The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. (PMID: 22871495) Chen L. … Kang C. (Carcinogenesis 2012) 67
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 67
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 67
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 67

Products for MIR524 Gene

Sources for MIR524 Gene

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