Aliases for MIR522 Gene
Subcategory (RNA class) for MIR522 Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR522 Gene
- HGNC: 32127
- Entrez Gene: 574495
- Ensembl: ENSG00000283685
- miRBase: hsa-mir-522
Previous HGNC Symbols for MIR522 Gene
- MIRN522
Previous GeneCards Identifiers for MIR522 Gene
- GC19P058978
- GC19P059021
- GC19P054254
Summaries for MIR522 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR522 Gene
MIR522 (MicroRNA 522) is an RNA Gene, and is affiliated with the miRNA class.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR522 Gene
Genomics for MIR522 Gene
Regulatory Element Products
Genomic Location for MIR522 Gene
- Chromosome:
- 19
- Start:
- 53,751,211 bp from pter
- End:
- 53,751,297 bp from pter
- Size:
- 87 bases
- Orientation:
- Plus strand
Genomic View for MIR522 Gene
Genes around MIR522 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.42 by Ensembl
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC
MIR522 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR522 Gene
No data available for Regulatory Elements for MIR522 Gene
Proteins for MIR522 Gene
Post-translational modifications for MIR522 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR522
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR522
- Origene Custom Protein Services for MIR522
- Search GeneTex for Proteins for MIR522
No data available for DME Specific Peptides for MIR522 Gene
Domains & Families for MIR522 Gene
Gene Families for MIR522 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR522 Gene
Function for MIR522 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR522
-
- Search ViGene Biosciences for MIR522
CRISPR Products
- Browse CRISPR knockouts for MIR522
miRNA Products
- Search ViGene Biosciences for MIR522
-
Origene geneexpression products in human, mouse, rat for MIR522
- Browse OriGene miRNA Products For MIR522
Inhibitory RNA Products
- Search ViGene Biosciences for MIR522
Clone Products
- GenScript: Custom all cDNA clones Services for MIR522
- VectorBuilder custom plasmid, inducible vectors for MIR522
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR522
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR522 Gene
Localization for MIR522 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR522 Gene
Transcripts for MIR522 Gene
mRNA/cDNA for MIR522 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR522
miRNA Products
- Search ViGene Biosciences for MIR522
-
Origene geneexpression products in human, mouse, rat for MIR522
- Browse OriGene miRNA Products For MIR522
Inhibitory RNA Products
- Search ViGene Biosciences for MIR522
Clone Products
- GenScript: Custom all cDNA clones Services for MIR522
- VectorBuilder custom plasmid, inducible vectors for MIR522
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR522
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for MIR522 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR522 Gene:
MIR522Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR522 Gene
Orthologs for MIR522 Gene
No data available for Orthologs for MIR522 Gene
Paralogs for MIR522 Gene
No data available for Paralogs for MIR522 Gene
Variants for MIR522 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000648907 | -- | 53,751,443(+) | TTCCA(A/G)CCTAG | downstream-variant-500B, upstream-variant-2KB | |
| rs1001419882 | -- | 53,749,307(+) | ATCAC(C/T)TGAGG | upstream-variant-2KB | |
| rs1002738325 | -- | 53,751,633(+) | TTTTT(A/G)TATTT | downstream-variant-500B, upstream-variant-2KB | |
| rs1003577896 | -- | 53,749,916(+) | TGTTA(C/T)TTCAA | upstream-variant-2KB | |
| rs1007323179 | -- | 53,750,223(+) | GTTGG(G/T)CAGGC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2448351 | CNV | deletion | 19546169 |
| esv2718812 | CNV | deletion | 23290073 |
| esv2718833 | CNV | deletion | 23290073 |
| nsv458781 | CNV | gain | 19166990 |
| nsv580108 | CNV | gain | 21841781 |
| nsv961246 | CNV | duplication | 23825009 |
Relevant External Links for MIR522 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR522
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR522 Gene
Disorders for MIR522 Gene
Relevant External Links for MIR522
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR522
No disorders were found for MIR522 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR522 Gene
Publications for MIR522 Gene
- miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2. (PMID: 26960688) Zhang H. … Sun C. (Tumour Biol. 2016) 3 64
- MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5. (PMID: 26043974) Yang G. … Wu D. (Mol Med Rep 2015) 3 64
- MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression. (PMID: 25776496) Zhang S. … Liu Y. (Biomed. Pharmacother. 2015) 3 64
- Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. (PMID: 25131211) Tan S.M. … Lieberman J. (Cell Rep 2014) 3 64
- miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
Products for MIR522 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR522
- Origene Custom Protein Services for MIR522
- Browse OriGene Inhibitory RNA Products For MIR522
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR522
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Origene geneexpression products in human, mouse, rat for MIR522
- Browse OriGene miRNA Products For MIR522
- GenScript: Custom all cDNA clones Services for MIR522
- GenScript Custom Purified and Recombinant Proteins Services for MIR522
- GenScript Custom Assay Services for MIR522
- GenScript Custom overexpressing Cell Line Services for MIR522
- Browse GenScript CRISPR for MIR522
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MIR522
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search GeneTex for Antibodies for MIR522
- Search GeneTex for Proteins for MIR522
- Search ViGene Biosciences for MIR522
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR522
- VectorBuilder custom plasmid, inducible vectors for MIR522
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR522
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR522 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer