Aliases for MIR522 Gene
Subcategory (RNA class) for MIR522 Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR522 Gene
- HGNC: 32127
- Entrez Gene: 574495
- Ensembl: ENSG00000283685
- miRBase: hsa-mir-522
Previous HGNC Symbols for MIR522 Gene
- MIRN522
Previous GeneCards Identifiers for MIR522 Gene
- GC19P058978
- GC19P059021
- GC19P054254
Summaries for MIR522 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR522 Gene
MIR522 (MicroRNA 522) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR522 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR522 Gene
Genomics for MIR522 Gene
Regulatory Element Products
Genomic Locations for MIR522 Gene
Genomic Locations for MIR522 Gene
- chr19:53,751,211-53,751,297
- (GRCh38/hg38)
- Size:
- 87 bases
- Orientation:
- Plus strand
- chr19:54,254,465-54,254,551
- (GRCh37/hg19)
Genomic View for MIR522 Gene
Genes around MIR522 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.42 by Ensembl
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC
MIR522 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR522 Gene
No data available for GeneHancer (GH) Regulatory Elements for MIR522 Gene
Proteins for MIR522 Gene
Post-translational modifications for MIR522 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR522
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR522
- Origene Custom Protein Services for MIR522
- Search GeneTex for Proteins for MIR522
No data available for DME Specific Peptides for MIR522 Gene
Domains & Families for MIR522 Gene
Gene Families for MIR522 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR522 Gene
Function for MIR522 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR522
-
- Search ViGene Biosciences for MIR522
CRISPR Products
- Browse CRISPR knockouts for MIR522
- Applied Biological Materials CRISPR for MIR522
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR522
Clone Products
- GenScript: Custom all cDNA clones Services for MIR522
- VectorBuilder custom plasmid, inducible vectors for MIR522
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR522
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR522
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR522 Gene
Localization for MIR522 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR522 Gene
Pathways & Interactions for MIR522 Gene
No Data Available
Interacting Proteins for MIR522 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for MIR522 Gene
Transcripts for MIR522 Gene
mRNA/cDNA for MIR522 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR522
- Applied Biological Materials CRISPR for MIR522
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR522
Clone Products
- GenScript: Custom all cDNA clones Services for MIR522
- VectorBuilder custom plasmid, inducible vectors for MIR522
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR522
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR522
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR522 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR522 Gene:
MIR522Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR522 Gene
Orthologs for MIR522 Gene
No data available for Orthologs for MIR522 Gene
Paralogs for MIR522 Gene
No data available for Paralogs for MIR522 Gene
Variants for MIR522 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000648907 | -- | 53,751,443(+) | A/G | downstream_transcript_variant | |
| rs1001419882 | -- | 53,749,307(+) | C/T | upstream_transcript_variant | |
| rs1002738325 | -- | 53,751,633(+) | G/A/T | downstream_transcript_variant | |
| rs1003577896 | -- | 53,749,916(+) | T/C | upstream_transcript_variant | |
| rs1007323179 | -- | 53,750,223(+) | T/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2448351 | CNV | deletion | 19546169 |
| esv2718812 | CNV | deletion | 23290073 |
| esv2718833 | CNV | deletion | 23290073 |
| nsv458781 | CNV | gain | 19166990 |
| nsv580108 | CNV | gain | 21841781 |
| nsv961246 | CNV | duplication | 23825009 |
Additional Variant Information for MIR522 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR522
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR522 Gene
Disorders for MIR522 Gene
Additional Disease Information for MIR522
No disorders were found for MIR522 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR522 Gene
Publications for MIR522 Gene
- Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis. (PMID: 28088550) Kang GJ … Lee CH (Biochimica et biophysica acta 2017) 3 58
- miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2. (PMID: 26960688) Zhang H … Sun C (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
- MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression. (PMID: 25776496) Zhang S … Liu Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015) 3 58
- MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5. (PMID: 26043974) Yang G … Wu D (Molecular medicine reports 2015) 3 58
- Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. (PMID: 25131211) Tan SM … Lieberman J (Cell reports 2014) 3 58
Products for MIR522 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody Services
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR522
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- GenScript: Custom all cDNA clones Services for MIR522
- GenScript Custom Purified and Recombinant Proteins Services for MIR522
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR522
- VectorBuilder custom plasmid, inducible vectors for MIR522
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR522
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR522
- Search GeneTex for Proteins for MIR522
Sources for MIR522 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew