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MIR522 Gene

RNA gene GIFtS: 20
GCID: GC19P054254

MicroRNA 522

(Previous symbol: MIRN522)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 522¹ ²
MIRN522¹ ²
hsa-mir-522²
mir-522⁹

External Ids:	HGNC: 32127¹	Entrez Gene: 574495²	Ensembl: ENSG00000207806⁷

ORGUL members:	fRNAdb¹⁰:FR338216

Export aliases for MIR522 gene to outside databases

Previous GC identifers: GC19P058978 GC19P059021

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR522 Gene:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of

gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are

transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can

be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme

to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the

cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The

mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through

imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of

the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR522 Gene:

MIR522 (microRNA 522) is an RNA gene, and is affiliated with the miRNA class.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Search for regulatory transcription factor binding sites for MIR522
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR522

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42

MIR522 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR522 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P054254: view genomic region (via miRBase) (about GC identifiers)

Start:	54,254,465 bp from pter	End:	54,254,551 bp from pter
Size:	87 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

MIR: ncRNAs / Micro RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MIR522
Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000385071(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR522:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MIR522 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for MIR522 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	ptr-mir-522⁶	ptr-mir-522	100(a)	1 ↔ 1	19(58660238-58660324)

ENSEMBL Gene Tree for MIR522 (if available)
TreeFam Gene Tree for MIR522 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191697860^1,2		--	54252608(+)	`ACCTCA/GACTCT`	1	--	us2k¹		0	--	--	--	--
rs28786116^1,2	F	--	54252654(+)	`GCTTGG/AGGGGC`	1	--	us2k¹		1		WA	118
rs142829411^1,2		--	54252658(+)	`GGGGGG/TCTGTG`	1	--	us2k¹		0	--	--	--	--
rs117015904^1,2	F	--	54252709(+)	`GAGACG/AAAATC`	1	--	us2k¹		1		NA	120
rs34288037^1,2	C,F	--	54252754(+)	`GATTCT/CGTCTC`	1	--	us2k¹		3		NA	124
rs305933^1,2	C,F,A,H	--	54252771(+)	`taaaTA/CAGTAG`	1	--	us2k¹		12		NS EA NA WA CSA	774
rs147406818^1,2		--	54252796(+)	`CTCACA/GTCTGT`	1	--	us2k¹		0	--	--	--	--
rs139719574^1,2		--	54252797(+)	`TCACGC/TCTGTA`	1	--	us2k¹		0	--	--	--	--
rs111494739^1,2	C	--	54252821(+)	`GGAGGC/-CAAGG`	1	--	us2k¹		1		CSA	2
rs305934^1,2	C,F	--	54252832(+)	`cgggtG/Aaatca`	1	--	us2k¹		5		NA WA	10

HapMap Linkage Disequilibrium report for MIR522 (54254465 - 54254551 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for MIR522: About this table

Variant ID	Type	Subtype	PubMed ID
esv2448351	CNV	Deletion	19546169
esv2718833	CNV	Deletion	23290073
esv2718812	CNV	Deletion	23290073
nsv458781	CNV	Gain	19166990
dgv3999n71	CNV	Gain	21882294
nsv912385	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MIR522 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MIR522)

Utopia: connect your pdf to the dynamic
world of online information

The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. (PubMed id 21533135)¹ Richardson K....Ordovas J.M. (PLoS ONE 2011)
Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)¹ Lui W.O....Fire A. (Cancer Res. 2007)
A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)¹ Landgraf P....Tuschl T. (Cell 2007)
miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832)¹ Griffiths-Jones S....Enright A.J. (Nucleic Acids Res. 2006)
Identification of hundreds of conserved and nonconserved human microRNAs. (PubMed id 15965474)¹ Bentwich I....Bentwich Z. (Nat. Genet. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 574495	HGNC: 32127	Ensembl:ENSG00000207806	miRBase: hsa-mir-522	euGenes: HUgn574495
ECgene: MIR522	H-InvDB: MIR522

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MIR522	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR522 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MIR522 gene:
Search GeneIP for patents involving MIR522

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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