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Aliases for MIR522 Gene

Subcategory (RNA class) for MIR522 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR522 Gene

  • MicroRNA 522 2 3
  • Hsa-Mir-522 3
  • MIRN522 3

External Ids for MIR522 Gene

ORGUL Members for MIR522 Gene

Previous HGNC Symbols for MIR522 Gene

  • MIRN522

Previous GeneCards Identifiers for MIR522 Gene

  • GC19P058978
  • GC19P059021
  • GC19P054254

Summaries for MIR522 Gene

Entrez Gene Summary for MIR522 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR522 Gene

MIR522 (MicroRNA 522) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR522 Gene

Genomics for MIR522 Gene

Genomic Location for MIR522 Gene

Start:
53,751,211 bp from pter
End:
53,751,297 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR522 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR522 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR522 Gene

No data available for Regulatory Elements for MIR522 Gene

Proteins for MIR522 Gene

Post-translational modifications for MIR522 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR522 Gene

Domains for MIR522 Gene

Gene Families for MIR522 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR522: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR522 Gene

Function for MIR522 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR522 Gene

Localization for MIR522 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR522 Gene

Pathways for MIR522 Gene

SuperPathways for MIR522 Gene

No Data Available

Interacting Proteins for MIR522 Gene

Gene Ontology (GO) - Biological Process for MIR522 Gene

None

No data available for Pathways by source for MIR522 Gene

Transcripts for MIR522 Gene

mRNA/cDNA for MIR522 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR522 Gene

No ASD Table

Relevant External Links for MIR522 Gene

GeneLoc Exon Structure for
MIR522
ECgene alternative splicing isoforms for
MIR522

Expression for MIR522 Gene

mRNA expression in normal human tissues for MIR522 Gene

genes like me logo Genes that share expressions with MIR522: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR522 Gene

Orthologs for MIR522 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR522 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-522 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR522:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR522 Gene

ENSEMBL:
Gene Tree for MIR522 (if available)
TreeFam:
Gene Tree for MIR522 (if available)

Paralogs for MIR522 Gene

No data available for Paralogs for MIR522 Gene

Variants for MIR522 Gene

Sequence variations from dbSNP and Humsavar for MIR522 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs186260 -- 53,749,958(+) TATGC(A/G)TAGGA upstream-variant-2KB
rs305933 -- 53,749,517(+) taaaT(A/C)AGTAG upstream-variant-2KB
rs305934 -- 53,749,578(+) cgggt(A/G)aatca upstream-variant-2KB
rs643404 -- 53,749,886(+) TCACC(C/T)TTGTG upstream-variant-2KB
rs643405 -- 53,749,891(+) TTTGT(G/T)CAGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR522 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2448351 CNV Deletion 19546169

Relevant External Links for MIR522 Gene

HapMap Linkage Disequilibrium report
MIR522

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR522 Gene

Disorders for MIR522 Gene

No disorders were found for MIR522 Gene.

No data available for UniProtKB/Swiss-Prot for MIR522 Gene

Publications for MIR522 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  5. The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. (PMID: 21533135) Richardson K. … Ordovas J.M. (PLoS ONE 2011) 3

Products for MIR522 Gene

Sources for MIR522 Gene

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