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Aliases for MIR520H Gene

Subcategory (RNA class) for MIR520H Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520H Gene

  • MicroRNA 520h 2 3
  • Hsa-Mir-520h 3
  • MIRN520H 3

External Ids for MIR520H Gene

ORGUL Members for MIR520H Gene

Previous Symbols for MIR520H Gene

  • MIRN520H

Summaries for MIR520H Gene

Entrez Gene Summary for MIR520H Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520H Gene

MIR520H (MicroRNA 520h) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR520H Gene

Genomics for MIR520H Gene

Genomic Location for MIR520H Gene

Start:
53,742,512 bp from pter
End:
53,742,599 bp from pter
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR520H Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR520H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520H Gene

No data available for Regulatory Elements for MIR520H Gene

Proteins for MIR520H Gene

Post-translational modifications for MIR520H Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520H Gene

Domains for MIR520H Gene

Gene Families for MIR520H Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR520H: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR520H Gene

Function for MIR520H Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR520H Gene

Localization for MIR520H Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR520H Gene

Pathways for MIR520H Gene

SuperPathways for MIR520H Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520H: view

Pathways by source for MIR520H Gene

1 KEGG pathway for MIR520H Gene

Interacting Proteins for MIR520H Gene

Gene Ontology (GO) - Biological Process for MIR520H Gene

None

Transcripts for MIR520H Gene

mRNA/cDNA for MIR520H Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520H Gene

No ASD Table

Relevant External Links for MIR520H Gene

GeneLoc Exon Structure for
MIR520H
ECgene alternative splicing isoforms for
MIR520H

Expression for MIR520H Gene

No Expression Related Data Available

Orthologs for MIR520H Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520H Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520g 37
  • 94 (a)
OneToMany
Species with no ortholog for MIR520H:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520H Gene

ENSEMBL:
Gene Tree for MIR520H (if available)
TreeFam:
Gene Tree for MIR520H (if available)

Paralogs for MIR520H Gene

No data available for Paralogs for MIR520H Gene

Variants for MIR520H Gene

Sequence variations from dbSNP and Humsavar for MIR520H Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3974839 -- 53,742,883(+) TCCTG(-/AGTAGCTG)GGATT downstream-variant-500B
rs4444438 -- 53,742,624(+) TGCTG(A/C)TGTTG downstream-variant-500B
rs11667270 -- 53,742,995(+) gggcc(A/G)tggca downstream-variant-500B
rs34630274 -- 53,742,681(+) CTGGG(-/GT)TTTTT downstream-variant-500B
rs56013413 -- 53,742,534(+) CTAGA(A/G)GAAGC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR520H Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718837 CNV Deletion 23290073
esv2448351 CNV Deletion 19546169
esv2718838 CNV Deletion 23290073

Relevant External Links for MIR520H Gene

HapMap Linkage Disequilibrium report
MIR520H

Disorders for MIR520H Gene

No disorders were found for MIR520H Gene.

No data available for UniProtKB/Swiss-Prot for MIR520H Gene

Publications for MIR520H Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. (PMID: 22887864) Padmanabhan R. … Gottesman M.M. (Stem Cells 2012) 3
  4. A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women. (PMID: 23364396) Tsai E.M. … Juo S.H. (J. Hum. Genet. 2013) 3
  5. Downregulation of histone deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect of doxorubicin. (PMID: 24316511) Shen Q. … Wang X. (FEBS Lett. 2014) 3

Products for MIR520H Gene

Sources for MIR520H Gene

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