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Aliases for MIR520G Gene

Subcategory (RNA class) for MIR520G Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520G Gene

  • MicroRNA 520g 2 3 5
  • Hsa-Mir-520g 3
  • Mir-520g 3
  • MIRN520G 3

External Ids for MIR520G Gene

ORGUL Members for MIR520G Gene

Previous HGNC Symbols for MIR520G Gene

  • MIRN520G

Previous GeneCards Identifiers for MIR520G Gene

  • GC19P058950
  • GC19P059009
  • GC19P054230
  • GC19P054243
  • GC19P054295
  • GC19P054325
  • GC19P054345
  • GC19P054416
  • GC19P054498

Summaries for MIR520G Gene

Entrez Gene Summary for MIR520G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520G Gene

MIR520G (MicroRNA 520g) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR520G Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR520G

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520G Gene

Genomics for MIR520G Gene

Regulatory Elements for MIR520G Gene

Enhancers for MIR520G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053611 1.2 ENCODE 10.8 -109.2 -109201 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF765 CDC42EP5 ENSG00000269288 ZNF347 PRPF31 MIR520A ZNF665 RNU6-698P MIR519B MIR525
GH19F053840 1.2 Ensembl ENCODE 10.5 +120.4 120435 4.0 PKNOX1 ARID4B SIN3A YBX1 ZNF121 FOS SP3 JUNB REST TBX21 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR515-2 MIR519C MIR1283-1 MIR520A MIR515-1
GH19F053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +123.1 123128 1.0 ZNF121 ZNF263 ZNF366 HLF EED CEBPB ZBTB17 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR519C MIR520A MIR515-1 MIR519E
GH19F053634 1 ENCODE 10.1 -87.1 -87146 2.0 HDGF PKNOX1 ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 ZNF207 FOS ZNF765 LENG1 MIR520A MIR526B MIR518F MIR519B MIR525 MIR518B MIR520B MIR520C
GH19F053898 0.9 Ensembl ENCODE 10.6 +176.7 176677 1.3 KLF1 PKNOX1 MAZ SP3 ZNF740 SP2 REST SP1 PATZ1 KLF9 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A MIR516A2 RNU6-1041P MIR1283-2 MIR516A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR520G on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR520G Gene

Chromosome:
19
Start:
53,722,166 bp from pter
End:
53,722,255 bp from pter
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR520G Gene

Genes around MIR520G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520G Gene

ORGUL Member Location for MIR520G Gene

ORGUL Member Location for MIR520G gene

Proteins for MIR520G Gene

Post-translational modifications for MIR520G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520G Gene

Domains & Families for MIR520G Gene

Gene Families for MIR520G Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR520G: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR520G Gene

Function for MIR520G Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520G Gene

Localization for MIR520G Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR520G Gene

Pathways & Interactions for MIR520G Gene

SuperPathways for MIR520G Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520G: view

Pathways by source for MIR520G Gene

1 KEGG pathway for MIR520G Gene

Interacting Proteins for MIR520G Gene

Gene Ontology (GO) - Biological Process for MIR520G Gene

None

No data available for SIGNOR curated interactions for MIR520G Gene

Transcripts for MIR520G Gene

fRNAdb Secondary structures for MIR520G Gene

  • FR126761
  • RF00639;mir-515;AEKP01200846.1/76-1

mRNA/cDNA for MIR520G Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520G Gene

No ASD Table

Relevant External Links for MIR520G Gene

GeneLoc Exon Structure for
MIR520G
ECgene alternative splicing isoforms for
MIR520G

Expression for MIR520G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520G Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR520G Gene:

MIR520G
genes like me logo Genes that share expression patterns with MIR520G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR520G Gene

Orthologs for MIR520G Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520g 35
  • 98 (a)
OneToMany
Species where no ortholog for MIR520G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520G Gene

ENSEMBL:
Gene Tree for MIR520G (if available)
TreeFam:
Gene Tree for MIR520G (if available)

Paralogs for MIR520G Gene

No data available for Paralogs for MIR520G Gene

Variants for MIR520G Gene

Sequence variations from dbSNP and Humsavar for MIR520G Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404336 -- 53,722,561(+) GGCCC(A/G)ACATC downstream-variant-500B
rs10415682 -- 53,720,739(+) gggcg(C/G)tgtgg upstream-variant-2KB
rs10426037 -- 53,722,362(+) CAGGG(A/T)CTCTG downstream-variant-500B
rs111404011 -- 53,721,561(+) CTGGA(A/G)TGCAG downstream-variant-500B, upstream-variant-2KB
rs112076618 -- 53,720,635(+) AACCC(A/G)GGAGG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR520G Gene

Variant ID Type Subtype PubMed ID
nsv961246 CNV duplication 23825009
nsv580108 CNV gain 21841781
nsv458781 CNV gain 19166990
esv2762049 CNV gain 21179565
esv2718837 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718812 CNV deletion 23290073

Relevant External Links for MIR520G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520G Gene

Disorders for MIR520G Gene

Relevant External Links for MIR520G

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR520G

No disorders were found for MIR520G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520G Gene

Publications for MIR520G Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 1 3 64
  2. Study on the relationship between miR-520g and the development of breast cancer. (PMID: 26957267) Ren G.B. … Mao Z.P. (Eur Rev Med Pharmacol Sci 2016) 3 64
  3. MicroRNA-520g induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7. (PMID: 25436421) Kan H. … Liu D. (FEBS Lett. 2015) 3 64
  4. MicroRNA-520g confers drug resistance by regulating p21 expression in colorectal cancer. (PMID: 25616665) Zhang Y. … Wang J. (J. Biol. Chem. 2015) 3 64
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64

Products for MIR520G Gene

Sources for MIR520G Gene

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