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Aliases for MIR520C Gene

Subcategory (RNA class) for MIR520C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520C Gene

  • MicroRNA 520c 2 3 5
  • Hsa-Mir-520c 3
  • MIRN520C 3

External Ids for MIR520C Gene

ORGUL Members for MIR520C Gene

Previous HGNC Symbols for MIR520C Gene

  • MIRN520C

Previous GeneCards Identifiers for MIR520C Gene

  • GC19P058930
  • GC19P059001
  • GC19P054210
  • GC19P053708
  • GC19P053737
  • GC19P053769
  • GC19P053803
  • GC19P053839

Summaries for MIR520C Gene

Entrez Gene Summary for MIR520C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520C Gene

MIR520C (MicroRNA 520c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR520C Gene

Genomics for MIR520C Gene

Regulatory Elements for MIR520C Gene

Enhancers for MIR520C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053611 1.4 ENCODE dbSUPER 10.8 -94.5 -94488 3.1 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF765 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C
GH19G053840 1.3 Ensembl ENCODE 10.5 +134.7 134676 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 GATA2 ZNF143 FOS SP3 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19G053659 1.1 ENCODE dbSUPER 11.1 -46.2 -46178 2.7 ELF3 PKNOX1 CREM SP3 SP5 REST PPARG SP1 ETV4 PBX2 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19G053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +137.6 137641 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19G053660 1 ENCODE dbSUPER 11.1 -48.0 -47952 0.2 HDAC1 CTCF ATF1 SAP30 MAX SIN3A RBBP5 RAD21 GATA3 POLR2A MIR520A RN7SL317P DPRX MIR526B MIR519B MIR525 MIR518B MIR518F MIR520B MIR520C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR520C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR520C Gene

Chromosome:
19
Start:
53,707,453 bp from pter
End:
53,707,539 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR520C Gene

Genes around MIR520C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520C Gene

Proteins for MIR520C Gene

Post-translational modifications for MIR520C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520C Gene

Domains & Families for MIR520C Gene

Gene Families for MIR520C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR520C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR520C Gene

Function for MIR520C Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520C Gene

Localization for MIR520C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR520C Gene

Pathways & Interactions for MIR520C Gene

SuperPathways for MIR520C Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520C: view

Pathways by source for MIR520C Gene

1 KEGG pathway for MIR520C Gene

Interacting Proteins for MIR520C Gene

Gene Ontology (GO) - Biological Process for MIR520C Gene

None

No data available for SIGNOR curated interactions for MIR520C Gene

Drugs & Compounds for MIR520C Gene

No Compound Related Data Available

Transcripts for MIR520C Gene

mRNA/cDNA for MIR520C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520C Gene

No ASD Table

Relevant External Links for MIR520C Gene

GeneLoc Exon Structure for
MIR520C
ECgene alternative splicing isoforms for
MIR520C

Expression for MIR520C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR520C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR520C Gene:

MIR520C
genes like me logo Genes that share expression patterns with MIR520C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520C Gene

Orthologs for MIR520C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520c 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR520C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520C Gene

ENSEMBL:
Gene Tree for MIR520C (if available)
TreeFam:
Gene Tree for MIR520C (if available)

Paralogs for MIR520C Gene

No data available for Paralogs for MIR520C Gene

Variants for MIR520C Gene

Sequence variations from dbSNP and Humsavar for MIR520C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000385722 -- 53,707,154(+) GCTCA(A/G)AATCC nc-transcript-variant, upstream-variant-2KB
rs1002041166 -- 53,706,078(+) TAGGC(A/T)AACCT intron-variant, upstream-variant-2KB
rs1002820702 -- 53,705,907(+) CTCCC(A/T)TCGGG intron-variant, upstream-variant-2KB
rs1003664802 -- 53,706,803(+) CCTGA(A/G)TAGCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003718699 -- 53,707,113(+) AGGAC(A/C/T)GTGCG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR520C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR520C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520C Gene

Disorders for MIR520C Gene

Relevant External Links for MIR520C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR520C

No disorders were found for MIR520C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520C Gene

Publications for MIR520C Gene

  1. Dual-Functions of miR-373 and miR-520c by Differently Regulating the Activities of MMP2 and MMP9. (PMID: 25545756) Lu S. … Liu P. (J. Cell. Physiol. 2015) 3 64
  2. Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells. (PMID: 26208390) Fomeshi M.R. … Khayatzadeh H. (Cell. Mol. Biol. Lett. 2015) 3 64
  3. Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development. (PMID: 24497838) Mazan-Mamczarz K. … Gartenhaus R.B. (PLoS Genet. 2014) 3 64
  4. MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-I_B and TGF-I^ signaling pathways. (PMID: 22158050) Keklikoglou I. … Tschulena U. (Oncogene 2012) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR520C Gene

Sources for MIR520C Gene

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