Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR520B Gene

Subcategory (RNA class) for MIR520B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520B Gene

  • MicroRNA 520b 2 3 5
  • Hsa-Mir-520b 3
  • MIRN520B 3

External Ids for MIR520B Gene

ORGUL Members for MIR520B Gene

Previous HGNC Symbols for MIR520B Gene

  • MIRN520B

Previous GeneCards Identifiers for MIR520B Gene

  • GC19P058919
  • GC19P058996
  • GC19P054204
  • GC19P053703
  • GC19P053733

Summaries for MIR520B Gene

Entrez Gene Summary for MIR520B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520B Gene

MIR520B (MicroRNA 520b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR520B Gene

Genomics for MIR520B Gene

Genomic Location for MIR520B Gene

Chromosome:
19
Start:
53,701,227 bp from pter
End:
53,701,287 bp from pter
Size:
61 bases
Orientation:
Plus strand

Genomic View for MIR520B Gene

Genes around MIR520B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520B Gene

No data available for Regulatory Elements for MIR520B Gene

Proteins for MIR520B Gene

Post-translational modifications for MIR520B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520B Gene

Domains & Families for MIR520B Gene

Gene Families for MIR520B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR520B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR520B Gene

Function for MIR520B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520B Gene

Localization for MIR520B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR520B Gene

Pathways & Interactions for MIR520B Gene

SuperPathways for MIR520B Gene

No Data Available

Interacting Proteins for MIR520B Gene

Gene Ontology (GO) - Biological Process for MIR520B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR520B Gene

Drugs & Compounds for MIR520B Gene

No Compound Related Data Available

Transcripts for MIR520B Gene

mRNA/cDNA for MIR520B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520B Gene

No ASD Table

Relevant External Links for MIR520B Gene

GeneLoc Exon Structure for
MIR520B
ECgene alternative splicing isoforms for
MIR520B

Expression for MIR520B Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR520B Gene

Orthologs for MIR520B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520b 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR520B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520B Gene

ENSEMBL:
Gene Tree for MIR520B (if available)
TreeFam:
Gene Tree for MIR520B (if available)

Paralogs for MIR520B Gene

No data available for Paralogs for MIR520B Gene

Variants for MIR520B Gene

Sequence variations from dbSNP and Humsavar for MIR520B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs762756345 -- 53,700,680(+) CACCT(C/T)GGCCT upstream-variant-2KB
rs141185546 -- 53,700,736(+) TACTT(C/G/T)TGTGT upstream-variant-2KB
rs113827731 -- 53,700,615(+) GTACA(C/G)ACATG upstream-variant-2KB
rs750034698 -- 53,700,629(+) TCTCC(A/G)TGTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR520B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718836 CNV Deletion 23290073

Relevant External Links for MIR520B Gene

HapMap Linkage Disequilibrium report
MIR520B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520B Gene

Disorders for MIR520B Gene

Relevant External Links for MIR520B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR520B

No disorders were found for MIR520B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520B Gene

Publications for MIR520B Gene

  1. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. (PMID: 25824049) Zhang W. … Zhang X. (Biochem. Biophys. Res. Commun. 2015) 3 67
  2. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. (PMID: 24886421) Zhang W. … Zhang X. (Mol. Cancer 2014) 3
  3. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1. (PMID: 22319632) Zhang W. … Zhang X. (PLoS ONE 2012) 3
  4. miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. (PMID: 21343296) Hu N. … Ye L. (J. Biol. Chem. 2011) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR520B Gene

Sources for MIR520B Gene

Back to Top

Content