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Aliases for MIR520B Gene

Subcategory (RNA class) for MIR520B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520B Gene

  • MicroRNA 520b 2 3 5
  • Hsa-Mir-520b 3
  • MIRN520B 3

External Ids for MIR520B Gene

ORGUL Members for MIR520B Gene

Previous HGNC Symbols for MIR520B Gene

  • MIRN520B

Previous GeneCards Identifiers for MIR520B Gene

  • GC19P058919
  • GC19P058996
  • GC19P054204
  • GC19P053703
  • GC19P053733
  • GC19P053767
  • GC19P053800

Summaries for MIR520B Gene

Entrez Gene Summary for MIR520B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520B Gene

MIR520B (MicroRNA 520b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR520B Gene

Genomics for MIR520B Gene

Regulatory Elements for MIR520B Gene

Enhancers for MIR520B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053790 0.2 ENCODE 12 +89.2 89155 0.2 ZBTB33 MIR516A2 MIR1283-2 MIR516A1 RNU6-1041P MIR519A1 MIR527 MIR521-1 RNU6-751P MIR517C MIR520H
GH19F053559 1 ENCODE 11.5 -141.9 -141916 0.1 ZSCAN18 ZNF157 ZNF18 MIR519B MIR525 MIR526B MIR520A MIR518B MIR518F MIR520B MIR520C MIR526A1 MIR521-2
GH19F053660 0.6 ENCODE 11.1 -41.7 -41726 0.2 HDAC1 CTCF ATF1 SIN3A RAD21 GATA3 FOXK2 POLR2A KLF8 ZNF740 MIR520A RN7SL317P DPRX MIR526B MIR519B MIR525 MIR518B MIR518F MIR520B MIR520C
GH19F053659 0.7 ENCODE 11.1 -40.0 -39952 2.7 SOX13 ELF3 KLF1 PKNOX1 SAP130 NR2F6 KLF8 CREM GATAD2A SOX5 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19F053611 0.2 ENCODE 10.8 -88.3 -88262 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF765 CDC42EP5 ENSG00000269288 ZNF347 PRPF31 MIR520A ZNF665 RNU6-698P MIR519B MIR525
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR520B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR520B Gene

Chromosome:
19
Start:
53,701,227 bp from pter
End:
53,701,287 bp from pter
Size:
61 bases
Orientation:
Plus strand

Genomic View for MIR520B Gene

Genes around MIR520B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520B Gene

Proteins for MIR520B Gene

Post-translational modifications for MIR520B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520B Gene

Domains & Families for MIR520B Gene

Gene Families for MIR520B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR520B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR520B Gene

Function for MIR520B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520B Gene

Localization for MIR520B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR520B Gene

Pathways & Interactions for MIR520B Gene

SuperPathways for MIR520B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520B: view

Pathways by source for MIR520B Gene

1 KEGG pathway for MIR520B Gene

Interacting Proteins for MIR520B Gene

Gene Ontology (GO) - Biological Process for MIR520B Gene

None

No data available for SIGNOR curated interactions for MIR520B Gene

Transcripts for MIR520B Gene

mRNA/cDNA for MIR520B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520B Gene

No ASD Table

Relevant External Links for MIR520B Gene

GeneLoc Exon Structure for
MIR520B
ECgene alternative splicing isoforms for
MIR520B

Expression for MIR520B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR520B Gene:

MIR520B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR520B Gene

Orthologs for MIR520B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520b 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR520B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520B Gene

ENSEMBL:
Gene Tree for MIR520B (if available)
TreeFam:
Gene Tree for MIR520B (if available)

Paralogs for MIR520B Gene

No data available for Paralogs for MIR520B Gene

Variants for MIR520B Gene

Sequence variations from dbSNP and Humsavar for MIR520B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10419695 -- 53,700,180(+) GTTGG(G/T)GTTTC downstream-variant-500B, upstream-variant-2KB
rs112074800 -- 53,700,506(+) GTGCA(C/G)TGGTG downstream-variant-500B, upstream-variant-2KB
rs112215460 -- 53,700,782(+) TAGCC(C/T)GTGGT intron-variant, upstream-variant-2KB
rs112254479 -- 53,700,839(+) TGTTA(C/T)GTTCC intron-variant, upstream-variant-2KB
rs112402190 -- 53,701,350(+) GCAGA(A/G)CATGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR520B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR520B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520B Gene

Disorders for MIR520B Gene

Relevant External Links for MIR520B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR520B

No disorders were found for MIR520B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520B Gene

Publications for MIR520B Gene

  1. MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven translocation 1 (TET1) mRNA. (PMID: 25824049) Zhang W. … Zhang X. (Biochem. Biophys. Res. Commun. 2015) 3 64
  2. Hepatitis B virus X protein accelerates hepatocarcinogenesis with partner survivin through modulating miR-520b and HBXIP. (PMID: 24886421) Zhang W. … Zhang X. (Mol. Cancer 2014) 3 64
  3. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1. (PMID: 22319632) Zhang W. … Zhang X. (PLoS ONE 2012) 3 64
  4. miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. (PMID: 21343296) Hu N. … Ye L. (J. Biol. Chem. 2011) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR520B Gene

Sources for MIR520B Gene

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