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Aliases for MIR520A Gene

Subcategory (RNA class) for MIR520A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520A Gene

  • MicroRNA 520a 2 3 5
  • Hsa-Mir-520a 3
  • MIRN520A 3

External Ids for MIR520A Gene

ORGUL Members for MIR520A Gene

Previous HGNC Symbols for MIR520A Gene

  • MIRN520A

Previous GeneCards Identifiers for MIR520A Gene

  • GC19P058886
  • GC19P054195
  • GC19P054196
  • GC19P054202
  • GC19P054221
  • GC19P054270
  • GC19P054318
  • GC19P054338
  • GC19P054410
  • GC19P054486

Summaries for MIR520A Gene

Entrez Gene Summary for MIR520A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520A Gene

MIR520A (MicroRNA 520a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR520A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR520A Gene

Genomics for MIR520A Gene

Regulatory Elements for MIR520A Gene

Enhancers for MIR520A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H053840 1.2 Ensembl ENCODE 11.1 +151.2 151248 2 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19H053659 1 ENCODE dbSUPER 13.1 -29.6 -29606 2 ELF3 SOX5 SOX13 GATAD2A SAP130 SP5 PPARG ETV4 CREB1 POU5F1 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19H053844 1.1 FANTOM5 Ensembl ENCODE 11.1 +154.2 154213 0 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19H053611 1 ENCODE dbSUPER 11.8 -77.9 -77916 3 SOX13 ESRRA FOXA2 TEAD3 CTBP1 GATA3 POLR2A NR2F6 SMARCE1 SOX5 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C MIR526A1
GH19H053898 0.9 Ensembl ENCODE 11 +208.0 207962 1 PKNOX1 MAZ SP3 KLF1 ZNF740 SP2 REST SP1 POLR2A PATZ1 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A MIR516A2 RNU6-1041P MIR519A1 RNU6-751P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR520A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR520A Gene

Chromosome:
19
Start:
53,690,881 bp from pter
End:
53,690,965 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR520A Gene

Genes around MIR520A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520A Gene

Proteins for MIR520A Gene

Post-translational modifications for MIR520A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520A Gene

Domains & Families for MIR520A Gene

Gene Families for MIR520A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR520A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR520A Gene

Function for MIR520A Gene

Phenotypes From GWAS Catalog for MIR520A Gene

Gene Ontology (GO) - Molecular Function for MIR520A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR520A: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR520A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520A Gene

Localization for MIR520A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520A Gene

Pathways & Interactions for MIR520A Gene

SuperPathways for MIR520A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520A: view

Pathways by source for MIR520A Gene

1 KEGG pathway for MIR520A Gene

Interacting Proteins for MIR520A Gene

Gene Ontology (GO) - Biological Process for MIR520A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 20190813
GO:0035195 gene silencing by miRNA IDA 20190813
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IDA 20190813
genes like me logo Genes that share ontologies with MIR520A: view

No data available for SIGNOR curated interactions for MIR520A Gene

Drugs & Compounds for MIR520A Gene

No Compound Related Data Available

Transcripts for MIR520A Gene

mRNA/cDNA for MIR520A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR520A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520A Gene

No ASD Table

Relevant External Links for MIR520A Gene

GeneLoc Exon Structure for
MIR520A
ECgene alternative splicing isoforms for
MIR520A

Expression for MIR520A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR520A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR520A Gene:

MIR520A
genes like me logo Genes that share expression patterns with MIR520A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520A Gene

Orthologs for MIR520A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520a 34
  • 99 (a)
OneToOne
Species where no ortholog for MIR520A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520A Gene

ENSEMBL:
Gene Tree for MIR520A (if available)
TreeFam:
Gene Tree for MIR520A (if available)

Paralogs for MIR520A Gene

No data available for Paralogs for MIR520A Gene

Variants for MIR520A Gene

Sequence variations from dbSNP and Humsavar for MIR520A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000130541 -- 53,688,923(+) TGCCA(G/T)TTTTT downstream-variant-500B, upstream-variant-2KB
rs1000290110 -- 53,690,561(+) ACTCA(A/G)GTGAA upstream-variant-2KB
rs1001078445 -- 53,689,689(+) GTAAA(C/T)GAAGC upstream-variant-2KB
rs1003201438 -- 53,689,768(+) GGTGT(A/G)AGCTG upstream-variant-2KB
rs1003234195 -- 53,689,525(+) ACACC(C/T)TTCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR520A Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718834 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR520A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520A Gene

Disorders for MIR520A Gene

Relevant External Links for MIR520A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR520A

No disorders were found for MIR520A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520A Gene

Publications for MIR520A Gene

  1. microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non-small cell lung cancer. (PMID: 27748920) Liu Y … Wang J (Oncology reports 2016) 3 60
  2. MicroRNA-520a attenuates proliferation of Raji cells through inhibition of AKT1/NF-κB and PERK/eIF2α signaling pathway. (PMID: 27461820) Wang X … Wang H (Oncology reports 2016) 3 60
  3. MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma. (PMID: 25816091) Dong Y … Li W (Molecular medicine reports 2015) 3 60
  4. A functional variant at miR-520a binding site in PIK3CA alters susceptibility to colorectal cancer in a Chinese Han population. (PMID: 25834816) Ding L … Li H (BioMed research international 2015) 3 60
  5. A global microRNA screen identifies regulators of the ErbB receptor signaling network. (PMID: 25630670) Bischoff A … Olayioye MA (Cell communication and signaling : CCS 2015) 3 60

Products for MIR520A Gene

Sources for MIR520A Gene

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