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Aliases for MIR519D Gene

Subcategory (RNA class) for MIR519D Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR519D Gene

  • MicroRNA 519d 2 3 5
  • Hsa-Mir-519d 3
  • Mir-519d 3
  • MIRN519D 3

External Ids for MIR519D Gene

ORGUL Members for MIR519D Gene

Previous HGNC Symbols for MIR519D Gene

  • MIRN519D

Previous GeneCards Identifiers for MIR519D Gene

  • GC19P058941
  • GC19P059005
  • GC19P054217
  • GC19P054220
  • GC19P054269
  • GC19P054317
  • GC19P054336
  • GC19P054409
  • GC19P054484

Summaries for MIR519D Gene

Entrez Gene Summary for MIR519D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519D Gene

MIR519D (MicroRNA 519d) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519D Gene

Genomics for MIR519D Gene

Regulatory Elements for MIR519D Gene

Enhancers for MIR519D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053790 0.2 ENCODE 12 +77.0 77035 0.2 ZBTB33 MIR516A2 RNU6-1041P MIR1283-2 MIR516A1 MIR519A1 MIR527 MIR521-1 RNU6-751P MIR517C MIR520H
GH19F053559 1 ENCODE 11.5 -154.0 -154036 0.1 ZSCAN18 ZNF157 ZNF18 MIR519B MIR525 MIR526B MIR520A MIR518B MIR518F MIR520B MIR520C MIR526A1 MIR521-2
GH19F053659 0.7 ENCODE 11.1 -52.1 -52072 2.7 SOX13 ELF3 KLF1 PKNOX1 SAP130 NR2F6 KLF8 CREM GATAD2A SOX5 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19F053660 0.6 ENCODE 11.1 -53.8 -53846 0.2 HDAC1 CTCF ATF1 SIN3A RAD21 GATA3 FOXK2 POLR2A KLF8 ZNF740 MIR520A RN7SL317P DPRX MIR526B MIR519B MIR525 MIR518B MIR518F MIR520B MIR520C
GH19F053611 0.2 ENCODE 10.8 -100.4 -100382 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF765 CDC42EP5 ENSG00000269288 ZNF347 PRPF31 MIR520A ZNF665 RNU6-698P MIR519B MIR525
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR519D on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR519D Gene

Chromosome:
19
Start:
53,713,347 bp from pter
End:
53,713,434 bp from pter
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR519D Gene

Genes around MIR519D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR519D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519D Gene

Proteins for MIR519D Gene

Post-translational modifications for MIR519D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519D Gene

Domains & Families for MIR519D Gene

Gene Families for MIR519D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519D Gene

Function for MIR519D Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519D Gene

Localization for MIR519D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519D Gene

Pathways & Interactions for MIR519D Gene

SuperPathways for MIR519D Gene

No Data Available

Interacting Proteins for MIR519D Gene

Gene Ontology (GO) - Biological Process for MIR519D Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR519D Gene

Transcripts for MIR519D Gene

mRNA/cDNA for MIR519D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519D Gene

No ASD Table

Relevant External Links for MIR519D Gene

GeneLoc Exon Structure for
MIR519D
ECgene alternative splicing isoforms for
MIR519D

Expression for MIR519D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR519D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR519D Gene:

MIR519D
genes like me logo Genes that share expression patterns with MIR519D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR519D Gene

Orthologs for MIR519D Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519d 35
  • 99 (a)
OneToOne
Species where no ortholog for MIR519D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519D Gene

ENSEMBL:
Gene Tree for MIR519D (if available)
TreeFam:
Gene Tree for MIR519D (if available)

Paralogs for MIR519D Gene

No data available for Paralogs for MIR519D Gene

Variants for MIR519D Gene

Sequence variations from dbSNP and Humsavar for MIR519D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10415111 -- 53,712,092(+) GTCAT(A/G)TATGC upstream-variant-2KB
rs112176957 -- 53,711,759(+) GGCCT(A/G)ATTTT upstream-variant-2KB
rs112375026 -- 53,711,501(+) CGAGG(C/T)GTGAT downstream-variant-500B, upstream-variant-2KB
rs112984024 -- 53,711,745(+) GAGCC(A/C)CCACG upstream-variant-2KB
rs113451126 -- 53,711,975(+) GGGGG(A/G)CCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR519D Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR519D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR519D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR519D Gene

Disorders for MIR519D Gene

Relevant External Links for MIR519D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR519D

No disorders were found for MIR519D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519D Gene

Publications for MIR519D Gene

  1. MiR-519d-3p suppresses invasion and migration of trophoblast cells via targeting MMP-2. (PMID: 25803859) Ding J. … Zhu X. (PLoS ONE 2015) 3 64
  2. miR-519d-mediated downregulation of STAT3 suppresses breast cancer progression. (PMID: 26238950) Deng X. … Wang B. (Oncol. Rep. 2015) 3 64
  3. C19MC microRNAs regulate the migration of human trophoblasts. (PMID: 25211593) Xie L. … Sadovsky Y. (Endocrinology 2014) 3 64
  4. Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells. (PMID: 25404641) Tsai C.H. … Tang C.H. (Oncotarget 2014) 3 64
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64

Products for MIR519D Gene

Sources for MIR519D Gene

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