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Aliases for MIR519C Gene

Subcategory (RNA class) for MIR519C Gene


Quality Score for this RNA gene is


Aliases for MIR519C Gene

  • MicroRNA 519c 2 3
  • Hsa-Mir-519c 3
  • Mir-519c 3
  • MIRN519C 3

External Ids for MIR519C Gene

ORGUL Members for MIR519C Gene

Previous HGNC Symbols for MIR519C Gene

  • MIRN519C

Previous GeneCards Identifiers for MIR519C Gene

  • GC19P058884
  • GC19P054190
  • GC19P054193
  • GC19P054207
  • GC19P054256
  • GC19P054305
  • GC19P054312
  • GC19P054334
  • GC19P054405
  • GC19P054482

Summaries for MIR519C Gene

Entrez Gene Summary for MIR519C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519C Gene

MIR519C (MicroRNA 519c) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519C Gene

Genomics for MIR519C Gene

Genomic Location for MIR519C Gene

53,686,469 bp from pter
53,686,555 bp from pter
87 bases
Plus strand

Genomic View for MIR519C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR519C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519C Gene

No data available for Regulatory Elements for MIR519C Gene

Proteins for MIR519C Gene

Post-translational modifications for MIR519C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519C Gene

Domains & Families for MIR519C Gene

Gene Families for MIR519C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519C Gene

Function for MIR519C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519C Gene

Localization for MIR519C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519C Gene

Pathways & Interactions for MIR519C Gene

SuperPathways for MIR519C Gene

No Data Available

Interacting Proteins for MIR519C Gene

Gene Ontology (GO) - Biological Process for MIR519C Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR519C Gene

Drugs & Compounds for MIR519C Gene

No Compound Related Data Available

Transcripts for MIR519C Gene

mRNA/cDNA for MIR519C Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519C Gene

No ASD Table

Relevant External Links for MIR519C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR519C Gene

mRNA expression in normal human tissues for MIR519C Gene

genes like me logo Genes that share expression patterns with MIR519C: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR519C Gene

Orthologs for MIR519C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-519c 36
  • 100 (a)
Species with no ortholog for MIR519C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519C Gene

Gene Tree for MIR519C (if available)
Gene Tree for MIR519C (if available)

Paralogs for MIR519C Gene

No data available for Paralogs for MIR519C Gene

Variants for MIR519C Gene

Sequence variations from dbSNP and Humsavar for MIR519C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10418042 -- 53,685,777(+) TGTGT(A/G)TGttt upstream-variant-2KB
rs10418934 -- 53,686,225(+) TGAAC(A/C)CTTAG upstream-variant-2KB
rs10420577 -- 53,686,175(+) CATTT(A/T)GGATG upstream-variant-2KB
rs10420625 -- 53,686,240(+) AAATC(C/T)ATTGC upstream-variant-2KB
rs10421255 -- 53,686,456(+) GGTGC(C/T)GGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR519C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073

Relevant External Links for MIR519C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR519C Gene

Disorders for MIR519C Gene

Relevant External Links for MIR519C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR519C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519C Gene

Publications for MIR519C Gene

  1. Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. (PMID: 22887864) Padmanabhan R. … Gottesman M.M. (Stem Cells 2012) 67
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 67
  3. Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. (PMID: 21219875) Li X. … Yu A.M. (Biochem. Pharmacol. 2011) 67
  4. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. (PMID: 20233879) Cha S.T. … Kuo M.L. (Cancer Res. 2010) 67
  5. Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2. (PMID: 19825807) To K.K. … Bates S.E. (Mol. Cancer Ther. 2009) 67

Products for MIR519C Gene

Sources for MIR519C Gene

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