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Aliases for MIR519C Gene

Subcategory (RNA class) for MIR519C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR519C Gene

  • MicroRNA 519c 2 3
  • Hsa-Mir-519c 3
  • MIRN519C 3

External Ids for MIR519C Gene

ORGUL Members for MIR519C Gene

Previous Symbols for MIR519C Gene

  • MIRN519C

Summaries for MIR519C Gene

Entrez Gene Summary for MIR519C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519C Gene

MIR519C (MicroRNA 519c) is a RNA Gene, and belongs to miRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519C Gene

Genomics for MIR519C Gene

Genomic Location for MIR519C Gene

Start:
53,686,469 bp from pter
End:
53,686,555 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR519C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR519C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519C Gene

No data available for Regulatory Elements for MIR519C Gene

Proteins for MIR519C Gene

Post-translational modifications for MIR519C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519C Gene

Domains for MIR519C Gene

Gene Families for MIR519C Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR519C: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR519C Gene

Function for MIR519C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR519C Gene

Localization for MIR519C Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR519C Gene

Pathways for MIR519C Gene

SuperPathways for MIR519C Gene

No Data Available

Interacting Proteins for MIR519C Gene

Gene Ontology (GO) - Biological Process for MIR519C Gene

None

No data available for Pathways by source for MIR519C Gene

Transcripts for MIR519C Gene

mRNA/cDNA for MIR519C Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519C Gene

No ASD Table

Relevant External Links for MIR519C Gene

GeneLoc Exon Structure for
MIR519C
ECgene alternative splicing isoforms for
MIR519C

Expression for MIR519C Gene

mRNA expression in normal human tissues for MIR519C Gene

genes like me logo Genes that share expressions with MIR519C: view

Orthologs for MIR519C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519c 37
  • 100 (a)
OneToOne
Species with no ortholog for MIR519C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519C Gene

ENSEMBL:
Gene Tree for MIR519C (if available)
TreeFam:
Gene Tree for MIR519C (if available)

Paralogs for MIR519C Gene

No data available for Paralogs for MIR519C Gene

Variants for MIR519C Gene

Sequence variations from dbSNP and Humsavar for MIR519C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10418042 -- 53,685,777(+) TGTGT(A/G)TGttt upstream-variant-2KB
rs10418934 -- 53,686,225(+) TGAAC(A/C)CTTAG upstream-variant-2KB
rs10420577 -- 53,686,175(+) CATTT(A/T)GGATG upstream-variant-2KB
rs10420625 -- 53,686,240(+) AAATC(C/T)ATTGC upstream-variant-2KB
rs10421255 -- 53,686,456(+) GGTGC(C/T)GGAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR519C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073

Relevant External Links for MIR519C Gene

HapMap Linkage Disequilibrium report
MIR519C

Disorders for MIR519C Gene

No disorders were found for MIR519C Gene.

No data available for UniProtKB/Swiss-Prot for MIR519C Gene

Publications for MIR519C Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line. (PMID: 18573883) To K.K. … Bates S.E. (Mol. Cell. Biol. 2008) 3
  5. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. (PMID: 19088191) Abdelmohsen K. … Gorospe M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3

Products for MIR519C Gene

Sources for MIR519C Gene

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