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Aliases for MIR519B Gene

Subcategory (RNA class) for MIR519B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR519B Gene

  • MicroRNA 519b 2 3
  • Hsa-Mir-519b 3
  • MIRN519B 3

External Ids for MIR519B Gene

ORGUL Members for MIR519B Gene

Previous HGNC Symbols for MIR519B Gene

  • MIRN519B

Previous GeneCards Identifiers for MIR519B Gene

  • GC19P058899
  • GC19P054198

Summaries for MIR519B Gene

Entrez Gene Summary for MIR519B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519B Gene

MIR519B (MicroRNA 519b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519B Gene

Genomics for MIR519B Gene

Genomic Location for MIR519B Gene

Start:
53,695,213 bp from pter
End:
53,695,293 bp from pter
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR519B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR519B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519B Gene

No data available for Regulatory Elements for MIR519B Gene

Proteins for MIR519B Gene

Post-translational modifications for MIR519B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519B Gene

Domains for MIR519B Gene

Gene Families for MIR519B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519B Gene

Function for MIR519B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR519B Gene

Localization for MIR519B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519B Gene

Pathways for MIR519B Gene

SuperPathways for MIR519B Gene

No Data Available

Interacting Proteins for MIR519B Gene

Gene Ontology (GO) - Biological Process for MIR519B Gene

None

No data available for Pathways by source for MIR519B Gene

Transcripts for MIR519B Gene

mRNA/cDNA for MIR519B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519B Gene

No ASD Table

Relevant External Links for MIR519B Gene

GeneLoc Exon Structure for
MIR519B
ECgene alternative splicing isoforms for
MIR519B

Expression for MIR519B Gene

mRNA expression in normal human tissues for MIR519B Gene

genes like me logo Genes that share expressions with MIR519B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR519B Gene

Orthologs for MIR519B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519b 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR519B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519B Gene

ENSEMBL:
Gene Tree for MIR519B (if available)
TreeFam:
Gene Tree for MIR519B (if available)

Paralogs for MIR519B Gene

No data available for Paralogs for MIR519B Gene

Variants for MIR519B Gene

Sequence variations from dbSNP and Humsavar for MIR519B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10420348 -- 53,695,305(+) GCAAC(A/G)GTGAA downstream-variant-500B
rs11672638 -- 53,695,207(+) CAAGA(A/G)GATCC upstream-variant-2KB
rs12980954 -- 53,695,515(+) CTTGC(G/T)CTGTG downstream-variant-500B
rs34243808 -- 53,695,499(+) TCCTC(-/T)TTTTT downstream-variant-500B
rs76249814 -- 53,695,476(+) ACGGT(C/T)CTCTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR519B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718834 CNV Deletion 23290073

Relevant External Links for MIR519B Gene

HapMap Linkage Disequilibrium report
MIR519B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR519B Gene

Disorders for MIR519B Gene

No disorders were found for MIR519B Gene.

No data available for UniProtKB/Swiss-Prot for MIR519B Gene

Publications for MIR519B Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. (PMID: 19088191) Abdelmohsen K. … Gorospe M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3
  5. An indirect role for oncomir-519b in the expression of truncated neurokinin-1 in breast cancer cells. (PMID: 22981979) Navarro P. … Rameshwar P. (Exp. Cell Res. 2012) 3

Products for MIR519B Gene

Sources for MIR519B Gene

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