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Aliases for MIR519A2 Gene

Subcategory (RNA class) for MIR519A2 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for MIR519A2 Gene

  • MicroRNA 519a-2 2 3 5
  • Hsa-Mir-519a-2 3
  • Mir-519a-2 3
  • MIRN519A-2 3
  • MIRN519A2 3

External Ids for MIR519A2 Gene

ORGUL Members for MIR519A2 Gene

Previous HGNC Symbols for MIR519A2 Gene

  • MIRN519A-2
  • MIRN519A2

Previous GeneCards Identifiers for MIR519A2 Gene

  • GC19P058990
  • GC19P059029
  • GC19P054266
  • GC19P054268
  • GC19P054316
  • GC19P054341
  • GC19P054426
  • GC19P054506
  • GC19P053762
  • GC19P053793

Summaries for MIR519A2 Gene

Entrez Gene Summary for MIR519A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519A2 Gene

MIR519A2 (MicroRNA 519a-2) is an RNA Gene, and is affiliated with the lncRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519A2 Gene

Genomics for MIR519A2 Gene

Regulatory Elements for MIR519A2 Gene

Enhancers for MIR519A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F054747 1.2 Ensembl 16.2 +985.9 985929 1.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D ZNF628 LENG1 LENG8-AS1 MIR519A2 PRPF31 ZNF784 SBK3 ENSG00000269275 ENSG00000235681 KIR2DL3
GH19F053977 1.1 ENCODE 16.2 +218.0 218001 5.8 PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 ZNF143 ZNF263 SP3 NFYC REST PRPF31 ZNF347 ZNF665 ERVV-2 CACNG8 CDC42EP5 MIR519A2 BIRC8 FAM90A28P ENSG00000269758
GH19F053878 1 ENCODE 16.3 +117.5 117549 1.4 CREB3L1 ARID4B GLI4 ZNF48 ZNF2 ETS1 SLC30A9 ELK1 ZNF143 SP3 ERVV-2 CDC42EP5 MIR519A2 VN1R4 BIRC8 FAM90A28P VN1R6P ENSG00000269758 LOC204800 ZNF765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR519A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR519A2 Gene

Chromosome:
19
Start:
53,761,961 bp from pter
End:
53,764,199 bp from pter
Size:
2,239 bases
Orientation:
Plus strand

Genomic View for MIR519A2 Gene

Genes around MIR519A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR519A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519A2 Gene

Proteins for MIR519A2 Gene

Post-translational modifications for MIR519A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519A2 Gene

Domains & Families for MIR519A2 Gene

Gene Families for MIR519A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519A2 Gene

Function for MIR519A2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519A2 Gene

Localization for MIR519A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519A2 Gene

Pathways & Interactions for MIR519A2 Gene

SuperPathways for MIR519A2 Gene

No Data Available

Interacting Proteins for MIR519A2 Gene

Gene Ontology (GO) - Biological Process for MIR519A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR519A2 Gene

Transcripts for MIR519A2 Gene

mRNA/cDNA for MIR519A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519A2 Gene

No ASD Table

Relevant External Links for MIR519A2 Gene

GeneLoc Exon Structure for
MIR519A2
ECgene alternative splicing isoforms for
MIR519A2

Expression for MIR519A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR519A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR519A2 Gene

This gene is overexpressed in Testis (x40.1) and Breast - Mammary Tissue (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR519A2 Gene:

MIR519A2
genes like me logo Genes that share expression patterns with MIR519A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR519A2 Gene

Orthologs for MIR519A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519a 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR519A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519A2 Gene

ENSEMBL:
Gene Tree for MIR519A2 (if available)
TreeFam:
Gene Tree for MIR519A2 (if available)

Paralogs for MIR519A2 Gene

No data available for Paralogs for MIR519A2 Gene

Variants for MIR519A2 Gene

Sequence variations from dbSNP and Humsavar for MIR519A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111267357 -- 53,762,869(+) CCTCC(C/G)AAGTA downstream-variant-500B
rs112302572 -- 53,762,878(+) TACTG(A/G)GATTA downstream-variant-500B
rs11360686 -- 53,762,526(+) CTTTG(-/T)TTTTT downstream-variant-500B
rs113768437 -- 53,762,847(+) CTCAA(A/G)CGATC downstream-variant-500B
rs114376869 -- 53,761,230(+) AGCAA(C/T)GTCGA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR519A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR519A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR519A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR519A2 Gene

Disorders for MIR519A2 Gene

Relevant External Links for MIR519A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR519A2

No disorders were found for MIR519A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519A2 Gene

Publications for MIR519A2 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. (PMID: 21083603) Kim T.H. … An H.J. (Histopathology 2010) 3 64
  3. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. (PMID: 19088191) Abdelmohsen K. … Gorospe M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR519A2 Gene

Sources for MIR519A2 Gene

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