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Aliases for MIR519A2 Gene

Subcategory (RNA class) for MIR519A2 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for MIR519A2 Gene

  • MicroRNA 519a-2 2 3
  • Hsa-Mir-519a-2 3
  • MIRN519A-2 3
  • MIRN519A2 3

External Ids for MIR519A2 Gene

ORGUL Members for MIR519A2 Gene

Previous Symbols for MIR519A2 Gene

  • MIRN519A-2
  • MIRN519A2

Summaries for MIR519A2 Gene

Entrez Gene Summary for MIR519A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519A2 Gene

MIR519A2 (MicroRNA 519a-2) is an RNA Gene, and belongs to the lncRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519A2 Gene

Genomics for MIR519A2 Gene

Genomic Location for MIR519A2 Gene

Start:
53,762,344 bp from pter
End:
53,762,430 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR519A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR519A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519A2 Gene

No data available for Regulatory Elements for MIR519A2 Gene

Proteins for MIR519A2 Gene

Post-translational modifications for MIR519A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519A2 Gene

Domains for MIR519A2 Gene

Gene Families for MIR519A2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519A2 Gene

Function for MIR519A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR519A2 Gene

Localization for MIR519A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519A2 Gene

Pathways for MIR519A2 Gene

SuperPathways for MIR519A2 Gene

No Data Available

Interacting Proteins for MIR519A2 Gene

Gene Ontology (GO) - Biological Process for MIR519A2 Gene

None

No data available for Pathways by source for MIR519A2 Gene

Transcripts for MIR519A2 Gene

mRNA/cDNA for MIR519A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519A2 Gene

No ASD Table

Relevant External Links for MIR519A2 Gene

GeneLoc Exon Structure for
MIR519A2
ECgene alternative splicing isoforms for
MIR519A2

Expression for MIR519A2 Gene

mRNA expression in normal human tissues for MIR519A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR519A2 Gene

This gene is overexpressed in Testis (40.1) and Breast - Mammary Tissue (4.6).
genes like me logo Genes that share expressions with MIR519A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MIR519A2 Gene

Orthologs for MIR519A2 Gene

Evolution for MIR519A2 Gene

ENSEMBL:
Gene Tree for MIR519A2 (if available)
TreeFam:
Gene Tree for MIR519A2 (if available)

No data available for Orthologs for MIR519A2 Gene

Paralogs for MIR519A2 Gene

No data available for Paralogs for MIR519A2 Gene

Variants for MIR519A2 Gene

Sequence variations from dbSNP and Humsavar for MIR519A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs614051 -- 53,762,024(+) GGAAC(C/G)CAAGT upstream-variant-2KB
rs626698 -- 53,762,569(+) gagtg(C/T)ggtgg downstream-variant-500B
rs627157 -- 53,762,676(+) gtgca(A/T)tatca downstream-variant-500B
rs851751 -- 53,762,888(+) acagg(C/T)gtgag downstream-variant-500B
rs2866108 -- 53,762,738(+) tcccg(A/T)gtagc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR519A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990

Relevant External Links for MIR519A2 Gene

HapMap Linkage Disequilibrium report
MIR519A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR519A2 Gene

Disorders for MIR519A2 Gene

No disorders were found for MIR519A2 Gene.

No data available for UniProtKB/Swiss-Prot for MIR519A2 Gene

Publications for MIR519A2 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. (PMID: 19088191) Abdelmohsen K. … Gorospe M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3
  5. Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. (PMID: 21083603) Kim T.H. … An H.J. (Histopathology 2010) 3

Products for MIR519A2 Gene

Sources for MIR519A2 Gene

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