Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR519A2 Gene

Subcategory (RNA class) for MIR519A2 Gene

miRNA

Quality Score for this RNA gene is

2

Aliases for MIR519A2 Gene

  • MicroRNA 519a-2 2 3
  • Hsa-Mir-519a-2 3
  • Mir-519a-2 3
  • MIRN519A-2 3
  • MIRN519A2 3

External Ids for MIR519A2 Gene

ORGUL Members for MIR519A2 Gene

Previous HGNC Symbols for MIR519A2 Gene

  • MIRN519A-2
  • MIRN519A2

Previous GeneCards Identifiers for MIR519A2 Gene

  • GC19P058990
  • GC19P059029
  • GC19P054266
  • GC19P054268
  • GC19P054316
  • GC19P054341
  • GC19P054426
  • GC19P054506

Summaries for MIR519A2 Gene

Entrez Gene Summary for MIR519A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519A2 Gene

MIR519A2 (MicroRNA 519a-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519A2 Gene

Genomics for MIR519A2 Gene

Genomic Location for MIR519A2 Gene

Chromosome:
19
Start:
53,762,344 bp from pter
End:
53,762,430 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR519A2 Gene

Genes around MIR519A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR519A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519A2 Gene

No data available for Regulatory Elements for MIR519A2 Gene

Proteins for MIR519A2 Gene

Post-translational modifications for MIR519A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519A2 Gene

Domains & Families for MIR519A2 Gene

Gene Families for MIR519A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519A2 Gene

Function for MIR519A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519A2 Gene

Localization for MIR519A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519A2 Gene

Pathways & Interactions for MIR519A2 Gene

SuperPathways for MIR519A2 Gene

No Data Available

Interacting Proteins for MIR519A2 Gene

Gene Ontology (GO) - Biological Process for MIR519A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR519A2 Gene

Drugs & Compounds for MIR519A2 Gene

No Compound Related Data Available

Transcripts for MIR519A2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519A2 Gene

No ASD Table

Relevant External Links for MIR519A2 Gene

GeneLoc Exon Structure for
MIR519A2
ECgene alternative splicing isoforms for
MIR519A2

No data available for mRNA/cDNA for MIR519A2 Gene

Expression for MIR519A2 Gene

mRNA expression in normal human tissues for MIR519A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR519A2 Gene

This gene is overexpressed in Testis (x40.1) and Breast - Mammary Tissue (x4.6).
genes like me logo Genes that share expression patterns with MIR519A2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR519A2 Gene

Orthologs for MIR519A2 Gene

No data available for Orthologs and Evolution for MIR519A2 Gene

Paralogs for MIR519A2 Gene

No data available for Paralogs for MIR519A2 Gene

Variants for MIR519A2 Gene

Sequence variations from dbSNP and Humsavar for MIR519A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs614051 -- 53,762,024(+) GGAAC(C/G)CAAGT upstream-variant-2KB
rs626698 -- 53,762,569(+) gagtg(C/T)ggtgg downstream-variant-500B
rs627157 -- 53,762,676(+) gtgca(A/T)tatca downstream-variant-500B
rs851751 -- 53,762,888(+) acagg(C/T)gtgag downstream-variant-500B
rs2866108 -- 53,762,738(+) tcccg(A/T)gtagc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR519A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990

Relevant External Links for MIR519A2 Gene

HapMap Linkage Disequilibrium report
MIR519A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR519A2 Gene

Disorders for MIR519A2 Gene

Relevant External Links for MIR519A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR519A2

No disorders were found for MIR519A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519A2 Gene

Publications for MIR519A2 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 67
  2. Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. (PMID: 21083603) Kim T.H. … An H.J. (Histopathology 2010) 3
  3. miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. (PMID: 19088191) Abdelmohsen K. … Gorospe M. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR519A2 Gene

Sources for MIR519A2 Gene

Back to Top

Content