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Aliases for MIR519A1 Gene

Subcategory (RNA class) for MIR519A1 Gene


Quality Score for this RNA gene is


Aliases for MIR519A1 Gene

  • MicroRNA 519a-1 2 3 5
  • Hsa-Mir-519a-1 3
  • Mir-519a-1 3
  • MIRN519A-1 3
  • MIRN519A1 3

External Ids for MIR519A1 Gene

ORGUL Members for MIR519A1 Gene

Previous HGNC Symbols for MIR519A1 Gene

  • MIRN519A-1
  • MIRN519A1

Previous GeneCards Identifiers for MIR519A1 Gene

  • GC19P058979
  • GC19P059022
  • GC19P054255

Summaries for MIR519A1 Gene

Entrez Gene Summary for MIR519A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519A1 Gene

MIR519A1 (MicroRNA 519a-1) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519A1 Gene

Genomics for MIR519A1 Gene

Genomic Location for MIR519A1 Gene

53,752,397 bp from pter
53,752,481 bp from pter
85 bases
Plus strand

Genomic View for MIR519A1 Gene

Genes around MIR519A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR519A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519A1 Gene

No data available for Regulatory Elements for MIR519A1 Gene

Proteins for MIR519A1 Gene

Post-translational modifications for MIR519A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519A1 Gene

Domains & Families for MIR519A1 Gene

Gene Families for MIR519A1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519A1 Gene

Function for MIR519A1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519A1 Gene

Localization for MIR519A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR519A1 Gene

Pathways & Interactions for MIR519A1 Gene

SuperPathways for MIR519A1 Gene

No Data Available

Interacting Proteins for MIR519A1 Gene

Gene Ontology (GO) - Biological Process for MIR519A1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR519A1 Gene

Drugs & Compounds for MIR519A1 Gene

No Compound Related Data Available

Transcripts for MIR519A1 Gene

mRNA/cDNA for MIR519A1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519A1 Gene

No ASD Table

Relevant External Links for MIR519A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR519A1 Gene

mRNA expression in normal human tissues for MIR519A1 Gene

genes like me logo Genes that share expression patterns with MIR519A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR519A1 Gene

Orthologs for MIR519A1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
Species with no ortholog for MIR519A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519A1 Gene

Gene Tree for MIR519A1 (if available)
Gene Tree for MIR519A1 (if available)

Paralogs for MIR519A1 Gene

No data available for Paralogs for MIR519A1 Gene

Variants for MIR519A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR519A1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2448351 CNV Deletion 19546169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR519A1 Gene

Disorders for MIR519A1 Gene

Relevant External Links for MIR519A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR519A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519A1 Gene

Publications for MIR519A1 Gene

  1. MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. (PMID: 24752803) Ward A. … Wiemann S. (J. Pathol. 2014) 3 67
  2. MicroRNA-519a demonstrates significant tumour suppressive activity in laryngeal squamous cells by targeting anti-carcinoma HuR gene. (PMID: 24300127) Shen Z. … Guo J. (J Laryngol Otol 2013) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3
  4. The two stem cell microRNA gene clusters C19MC and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas. (PMID: 20209130) Rippe V. … Bullerdiek J. (PLoS ONE 2010) 3
  5. Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. (PMID: 21083603) Kim T.H. … An H.J. (Histopathology 2010) 3

Products for MIR519A1 Gene

Sources for MIR519A1 Gene