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Aliases for MIR5196 Gene

Subcategory (RNA class) for MIR5196 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5196 Gene

  • MicroRNA 5196 2 3
  • Sialic Acid-Binding Ig-Like Lectin 2 4
  • B-Lymphocyte Cell Adhesion Molecule 4
  • T-Cell Surface Antigen Leu-14 4
  • CD22 Molecule 5
  • CD22 Antigen 4
  • Hsa-Mir-5196 3
  • SIGLEC-2 4
  • Mir-5196 3
  • SIGLEC2 4
  • BL-CAM 4
  • CD22 5

External Ids for MIR5196 Gene

Previous GeneCards Identifiers for MIR5196 Gene

  • GC19U901559
  • GC19P035840
  • GC19P035848
  • GC19P035959
  • GC19P035502
  • GC19P035511
  • GC19P035520
  • GC19P035323

Summaries for MIR5196 Gene

Entrez Gene Summary for MIR5196 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5196 Gene

MIR5196 (MicroRNA 5196) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and B cell receptor signaling pathway (KEGG). An important paralog of this gene is SIGLEC1.

UniProtKB/Swiss-Prot for MIR5196 Gene

  • Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5196 Gene

Genomics for MIR5196 Gene

Regulatory Elements for MIR5196 Gene

Enhancers for MIR5196 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035277 1.2 Ensembl ENCODE 11.8 -38.8 -38827 6.7 PKNOX1 ZNF493 ARID4B DMAP1 ZNF48 YY1 ZNF121 GLIS2 KLF7 SP5 RBM42 TMEM147-AS1 ZNF792 CD22 ENSG00000267049 ENSG00000268947 FAM187B KMT2B MAG ENSG00000271032
GH19F035284 0.4 Ensembl 11.7 -34.5 -34461 1.2 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A GLIS2 ELK1 ZNF143 ZNF207 KLF13 MAG MIR5196 CD22 FAM187B KRTDAP DMKN ENSG00000233214 FFAR2 ATP4A TMEM147
GH19F035433 1.3 FANTOM5 Ensembl ENCODE 10.3 +116.8 116840 5.8 ELF3 HDAC1 PKNOX1 THRB RAD21 RARA YY1 ZNF121 SCRT2 ETV6 NFKBID TMEM147-AS1 FFAR2 KRTDAP DMKN CD22 MIR5196 SBSN FAM187B TYROBP
GH19F035316 1.5 FANTOM5 Ensembl ENCODE 0.8 -0.5 -474 5.2 HDGF PKNOX1 MLX SIN3A ZNF2 ZNF48 SLC30A9 ZNF121 FOS ZNF263 MAG TMEM147-AS1 HAUS5 KMT2B SDHAF1 ZNF792 LIN37 CD22 FFAR3 FFAR2
GH19F035322 0.9 Ensembl ENCODE 0.8 +4.6 4561 2.6 HDGF PKNOX1 ZFP64 ZNF493 ZNF121 ZNF302 KLF7 ZNF548 ZNF202 SP3 TMEM147-AS1 HAUS5 KMT2B ZNF792 RBM42 ZNF146 ENSG00000267049 SDHAF1 WTIP LINC01766
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR5196 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5196 Gene

Chromosome:
19
Start:
35,319,261 bp from pter
End:
35,347,355 bp from pter
Size:
28,095 bases
Orientation:
Plus strand

Genomic View for MIR5196 Gene

Genes around MIR5196 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5196 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5196 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5196 Gene

Proteins for MIR5196 Gene

  • Protein details for MIR5196 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20273-CD22_HUMAN
    Recommended name:
    B-cell receptor CD22
    Protein Accession:
    P20273
    Secondary Accessions:
    • F5GYU4
    • F5H7U3
    • O95699
    • O95701
    • O95702
    • O95703
    • Q01665
    • Q32M46
    • Q92872
    • Q92873
    • Q9UQA6
    • Q9UQA7
    • Q9UQA8
    • Q9UQA9
    • Q9UQB0
    • Q9Y2A6

    Protein attributes for MIR5196 Gene

    Size:
    847 amino acids
    Molecular mass:
    95348 Da
    Quaternary structure:
    • Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.
    • Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.
    SequenceCaution:
    • Sequence=CAA36988.1; Type=Frameshift; Positions=806; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR5196 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR5196 Gene

Post-translational modifications for MIR5196 Gene

  • Phosphorylated on tyrosine residues by LYN.
  • Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
  • Glycosylation at Asn 67, Asn 101, Asn 112, Asn 135, Asn 164, Asn 231, Asn 363, Asn 445, Asn 479, Asn 574, and Asn 634
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR5196 Gene

Domains & Families for MIR5196 Gene

Graphical View of Domain Structure for InterPro Entry

P20273

UniProtKB/Swiss-Prot:

CD22_HUMAN :
  • Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with MIR5196: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5196 Gene

Function for MIR5196 Gene

Molecular function for MIR5196 Gene

UniProtKB/Swiss-Prot Function:
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Gene Ontology (GO) - Molecular Function for MIR5196 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MIR5196: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5196 Gene

Localization for MIR5196 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5196 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for MIR5196 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MIR5196: view

No data available for Subcellular locations from COMPARTMENTS for MIR5196 Gene

Pathways & Interactions for MIR5196 Gene

genes like me logo Genes that share pathways with MIR5196: view

Gene Ontology (GO) - Biological Process for MIR5196 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with MIR5196: view

No data available for SIGNOR curated interactions for MIR5196 Gene

Transcripts for MIR5196 Gene

mRNA/cDNA for MIR5196 Gene

(35) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5196 Gene

No ASD Table

Relevant External Links for MIR5196 Gene

GeneLoc Exon Structure for
MIR5196
ECgene alternative splicing isoforms for
MIR5196

Expression for MIR5196 Gene

mRNA expression in normal human tissues for MIR5196 Gene

mRNA differential expression in normal tissues according to GTEx for MIR5196 Gene

This gene is overexpressed in Spleen (x9.4) and Ovary (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of MIR5196 Gene:

MIR5196

mRNA Expression by UniProt/SwissProt for MIR5196 Gene:

P20273-CD22_HUMAN
Tissue specificity: B-lymphocytes.
genes like me logo Genes that share expression patterns with MIR5196: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR5196 Gene

Orthologs for MIR5196 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR5196 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD22 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD22 35
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd22 35
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD22 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD22 35
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD22 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 25 (a)
OneToMany
-- 35
  • 25 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01058865.1 35
  • 30 (a)
ManyToMany
si:dkey-27j5.10 35
  • 30 (a)
ManyToMany
si:ch211-1f22.14 35
  • 25 (a)
ManyToMany
Species where no ortholog for MIR5196 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR5196 Gene

ENSEMBL:
Gene Tree for MIR5196 (if available)
TreeFam:
Gene Tree for MIR5196 (if available)

Paralogs for MIR5196 Gene

Paralogs for MIR5196 Gene

genes like me logo Genes that share paralogs with MIR5196: view

Variants for MIR5196 Gene

Sequence variations from dbSNP and Humsavar for MIR5196 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406069 -- 35,345,627(+) TGAAG(A/G)CCCCC intron-variant, nc-transcript-variant, reference, missense
rs10406539 -- 35,345,867(+) CTCTG(A/G)GTAAG intron-variant, downstream-variant-500B
rs10407974 -- 35,345,425(+) caaaa(A/C)aaaaa intron-variant, upstream-variant-2KB
rs10413500 -- 35,345,923(+) CATGC(C/G)CAGTC intron-variant, downstream-variant-500B
rs10413526 -- 35,345,952(+) CAAGA(C/G)CTCAT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR5196 Gene

Variant ID Type Subtype PubMed ID
esv2758758 CNV loss 17122850
nsv1067129 CNV loss 25217958
nsv510765 CNV deletion 20534489
nsv833810 CNV gain 17160897

Relevant External Links for MIR5196 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5196

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5196 Gene

Disorders for MIR5196 Gene

Relevant External Links for MIR5196

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5196

No disorders were found for MIR5196 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5196 Gene

Publications for MIR5196 Gene

  1. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for MIR5196 Gene

Sources for MIR5196 Gene

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