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Aliases for MIR5193 Gene

Subcategory (RNA class) for MIR5193 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5193 Gene

  • MicroRNA 5193 2 3
  • UBA7 4 5
  • Ubiquitin Like Modifier Activating Enzyme 7 5
  • Ubiquitin-Activating Enzyme E1 Homolog 4
  • Ubiquitin-Activating Enzyme 7 4
  • Hsa-Mir-5193 3
  • Mir-5193 3
  • UBE1L 4
  • UBE2 4
  • D8 4

External Ids for MIR5193 Gene

Previous GeneCards Identifiers for MIR5193 Gene

  • GC03U901841
  • GC03M049847
  • GC03M049849

Summaries for MIR5193 Gene

Entrez Gene Summary for MIR5193 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5193 Gene

MIR5193 (MicroRNA 5193) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Interferon gamma signaling and Immune System. An important paralog of this gene is UBA1.

UniProtKB/Swiss-Prot for MIR5193 Gene

  • Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5193 Gene

Genomics for MIR5193 Gene

Regulatory Elements for MIR5193 Gene

Enhancers for MIR5193 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049812 0.4 ENCODE 0.8 0.0 -10 2.5 ELF3 IRF2 TFAP4 ZNF146 SAP130 ASH2L ARID4B ZBTB40 GATAD1 POLR2A CDHR4 MIR5193 UBA7
GH03F049802 0.6 ENCODE 0.4 +8.2 8169 7.2 HDGF MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 CDHR4 FAM212A AMT WDR6 MIR5193
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR5193 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5193 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001847754 646 201

Genomic Location for MIR5193 Gene

Chromosome:
3
Start:
49,805,207 bp from pter
End:
49,813,946 bp from pter
Size:
8,740 bases
Orientation:
Minus strand

Genomic View for MIR5193 Gene

Genes around MIR5193 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5193 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5193 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5193 Gene

Proteins for MIR5193 Gene

  • Protein details for MIR5193 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41226-UBA7_HUMAN
    Recommended name:
    Ubiquitin-like modifier-activating enzyme 7
    Protein Accession:
    P41226
    Secondary Accessions:
    • Q9BRB2

    Protein attributes for MIR5193 Gene

    Size:
    1012 amino acids
    Molecular mass:
    111694 Da
    Quaternary structure:
    • Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
    • Monomer (By similarity). Binds and is involved in the conjugation of G1P2/ISG15.
    Miscellaneous:
    • There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.

neXtProt entry for MIR5193 Gene

Post-translational modifications for MIR5193 Gene

Other Protein References for MIR5193 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR5193 Gene

Domains & Families for MIR5193 Gene

Graphical View of Domain Structure for InterPro Entry

P41226

UniProtKB/Swiss-Prot:

UBA7_HUMAN :
  • Belongs to the ubiquitin-activating E1 family.
Family:
  • Belongs to the ubiquitin-activating E1 family.
genes like me logo Genes that share domains with MIR5193: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5193 Gene

Function for MIR5193 Gene

Molecular function for MIR5193 Gene

UniProtKB/Swiss-Prot Function:
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Ontology (GO) - Molecular Function for MIR5193 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004839 ubiquitin activating enzyme activity IBA --
GO:0004842 ubiquitin-protein transferase activity EXP --
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
GO:0008641 small protein activating enzyme activity IEA --
genes like me logo Genes that share ontologies with MIR5193: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5193 Gene

Localization for MIR5193 Gene

Gene Ontology (GO) - Cellular Components for MIR5193 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR5193: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MIR5193 Gene

Pathways & Interactions for MIR5193 Gene

genes like me logo Genes that share pathways with MIR5193: view

UniProtKB/Swiss-Prot P41226-UBA7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MIR5193 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IDA --
GO:0016567 protein ubiquitination IEA --
GO:0019941 modification-dependent protein catabolic process IEA --
GO:0019985 translesion synthesis TAS --
GO:0032020 ISG15-protein conjugation IDA --
genes like me logo Genes that share ontologies with MIR5193: view

No data available for SIGNOR curated interactions for MIR5193 Gene

Transcripts for MIR5193 Gene

mRNA/cDNA for MIR5193 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5193 Gene

No ASD Table

Relevant External Links for MIR5193 Gene

GeneLoc Exon Structure for
MIR5193
ECgene alternative splicing isoforms for
MIR5193

Expression for MIR5193 Gene

mRNA expression in normal human tissues for MIR5193 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5193 Gene:

MIR5193

mRNA Expression by UniProt/SwissProt for MIR5193 Gene:

P41226-UBA7_HUMAN
Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.
genes like me logo Genes that share expression patterns with MIR5193: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR5193 Gene

Orthologs for MIR5193 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR5193 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBA7 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBA7 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBA7 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uba7 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBA7 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBA7 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBA7 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBA7 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uba7 35
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Uba1 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea uba-1 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBA1 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for MIR5193 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR5193 Gene

ENSEMBL:
Gene Tree for MIR5193 (if available)
TreeFam:
Gene Tree for MIR5193 (if available)

Paralogs for MIR5193 Gene

Paralogs for MIR5193 Gene

genes like me logo Genes that share paralogs with MIR5193: view

Variants for MIR5193 Gene

Sequence variations from dbSNP and Humsavar for MIR5193 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111694892 -- 49,807,683(+) GCAGG(C/T)GCAGG intron-variant, upstream-variant-2KB
rs113678142 -- 49,807,690(+) CAGGG(A/G)AAACC intron-variant, upstream-variant-2KB
rs114272505 -- 49,808,010(+) AAGGG(A/G/T)TGGGG intron-variant, upstream-variant-2KB
rs114468755 -- 49,807,737(+) TCACC(A/G)TCTGG upstream-variant-2KB, reference, missense
rs114700243 -- 49,807,149(+) CATGC(C/G)CACAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR5193 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Relevant External Links for MIR5193 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5193

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5193 Gene

Disorders for MIR5193 Gene

Relevant External Links for MIR5193

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5193

No disorders were found for MIR5193 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5193 Gene

Publications for MIR5193 Gene

  1. Human miR-5193 Triggers Gene Silencing in Multiple Genotypes of Hepatitis B Virus. (PMID: 26456535) Khlaiphuengsin A. … Payungporn S. (Microrna 2015) 3 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. Covalent protein modification with ISG15 via a conserved cysteine in the hinge region. (PMID: 22693631) Bade V.N. … Praefcke G.J. (PLoS ONE 2012) 4 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64

Products for MIR5193 Gene

Sources for MIR5193 Gene

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