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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MIR518E Gene

RNA gene GIFtS: 19
GCID: GC19P054233

microRNA 518e

(Previous symbol: MIRN518E)

Search for MIR518E
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 9

Aliases
MicroRNA 518e¹ ²
MIRN518E¹ ²
Hsa-Mir-518e¹
Mir-518e¹

External Ids:	HGNC: 32119¹	Entrez Gene: 574487²	Ensembl: ENSG00000207987⁷

ORGUL members:	fRNAdb¹⁰:FR309400 FR309400 FR186034 FR359003
	miRBase:MI0003169 MIMAT0002831 MIMAT0002861 MIMAT0005452 MIMAT0005450	see all 8
	Rfam:RF00639

Export aliases for MIR518E gene to outside databases

Previous GC identifers: GC19P058966 GC19P059012

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR518E:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene

expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed

by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either

protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an

approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer

ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated

into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the

miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq

represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

fRNAdb sequence ontologies for MIR518E - the ORGUL cluster for this gene includes several descriptions:
microRNA mir-515 -
pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR518E

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MIR518E
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR518E

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42

MIR518E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR518E gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P054233: view genomic region (via miRBase) (about GC identifiers)

Start:	54,233,092 bp from pter	End:	54,233,179 bp from pter
Size:	88 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

hsa-mir-518e_hairpin
FR0309400
RF00639
hsa-miR-523-5p_mature
hsa-miR-522-5p_mature
hsa-miR-519b-5p_mature
hsa-miR-518e-5p_mature
hsa-miR-519a-5p_mature
hsa-miR-519c-5p_mature
FR0186034
hsa-miR-518e-3p_mature
FR0359003

miRNA
Full Legend

54233091 54233135 54233179 chr19

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MIR518E

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about MIR518E

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

3 fRNAdb Secondary structures:

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000385252(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR518E:miRBase

MIR518E expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SABiosciences Custom PCR Arrays for MIR518E

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for MIR518E (if available)
TreeFam Gene Tree for MIR518E (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MIR518E gene

MIR524² MIR518D² MIR520G² MIR519D² MIR526A1² MIR520A² MIR519C² MIR518B²

MIR517B² MIR522² MIR521-2² MIR520C² MIR516B2² MIR526A2² MIR523² MIR518C²

MIR519A1² MIR519B² MIR519A2² MIR520B² MIR526B² MIR1283-1² MIR1283-2² MIR517A²

MIR520D² MIR515-1² MIR521-1² MIR518A2² MIR517C² MIR516A1² MIR520H² MIR520E²

MIR525² MIR516B1² MIR520F² MIR516A2² MIR527² MIR519E² MIR518F² MIR515-2²

MIR518A1²

MIR518E for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148141135^1,2		--	54231099(+)	`ATGGGA/GCGTGC`	1	--	us2k¹		0	--	--	--	--
rs187834830^1,2		--	54231171(+)	`TCTCAA/GCACCT`	1	--	us2k¹		0	--	--	--	--
rs141390512^1,2		--	54231192(+)	`ATTCCA/GCAGGC`	1	--	us2k¹		0	--	--	--	--
rs7253869^1,2	C,F,A,H,	--	54231277(+)	`GCCACC/TGCAGA`	1	--	us2k¹		18		NS EA NA CSA WA	2330
rs145180598^1,2		--	54231286(+)	`GATCCC/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs149608196^1,2		--	54231344(+)	`GTTTT-/TTTG TTTGT`	1	--	us2k¹		0	--	--	--	--
rs150961353^1,2		--	54231345(+)	`GTTTT-/TTT GTTTGTTTGT`	1	--	us2k¹		0	--	--	--	--
rs74177811^1,2	C	--	54231376(+)	`GTTTGTTTG/- ACAGA`	1	--	us2k¹		1		NA	2
rs76002413^1,2		--	54231396(+)	`TGTTGC/TCTGGC`	1	--	us2k¹		4		CSA WA NA EA	360
rs192937452^1,2		--	54231416(+)	`ATGATA/GTGATC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MIR518E (54233092 - 54233179 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIR518E
1 CNV: 102875

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MIR518E gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR518E)

Utopia: connect your pdf to the dynamic
world of online information

A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)¹ Landgraf P....Tuschl T. (2007)
miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)¹ Griffiths-Jones S....Enright A.J. (2006)
Identification of hundreds of conserved and nonconser ved human microRNAs. (PubMed id 15965474)¹ Bentwich I....Bentwich Z. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 574487	HGNC: 32119	Ensembl:ENSG00000207987	miRBase: hsa-mir-518e	euGenes: HUgn574487
ECgene: MIR518E	H-InvDB: MIR518E

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MIR518E	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR518E gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MIR518E gene:
Search GeneIP for patents involving MIR518E

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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