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Aliases for MIR518B Gene

Subcategory (RNA class) for MIR518B Gene


Quality Score for this RNA gene is


Aliases for MIR518B Gene

  • MicroRNA 518b 2 3 5
  • Hsa-Mir-518b 3
  • Mir-518b 3
  • MIRN518B 3

External Ids for MIR518B Gene

ORGUL Members for MIR518B Gene

Previous HGNC Symbols for MIR518B Gene

  • MIRN518B

Previous GeneCards Identifiers for MIR518B Gene

  • GC19P058925
  • GC19P058997
  • GC19P054205
  • GC19P053705
  • GC19P053735
  • GC19P053768
  • GC19P053802
  • GC19P053838

Summaries for MIR518B Gene

Entrez Gene Summary for MIR518B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518B Gene

MIR518B (MicroRNA 518b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR518B Gene

Genomics for MIR518B Gene

Regulatory Elements for MIR518B Gene

Enhancers for MIR518B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053611 1.4 ENCODE dbSUPER 10.8 -89.8 -89772 3.1 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF765 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C
GH19G053840 1.3 Ensembl ENCODE 10.5 +139.4 139392 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 GATA2 ZNF143 FOS SP3 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19G053659 1.1 ENCODE dbSUPER 11.1 -41.5 -41462 2.7 ELF3 PKNOX1 CREM SP3 SP5 REST PPARG SP1 ETV4 PBX2 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19G053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +142.4 142357 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19G053660 1 ENCODE dbSUPER 11.1 -43.2 -43236 0.2 HDAC1 CTCF ATF1 SAP30 MAX SIN3A RBBP5 RAD21 GATA3 POLR2A MIR520A RN7SL317P DPRX MIR526B MIR519B MIR525 MIR518B MIR518F MIR520B MIR520C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR518B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR518B Gene

53,702,737 bp from pter
53,702,819 bp from pter
83 bases
Plus strand

Genomic View for MIR518B Gene

Genes around MIR518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518B Gene

Proteins for MIR518B Gene

Post-translational modifications for MIR518B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518B Gene

Domains & Families for MIR518B Gene

Gene Families for MIR518B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR518B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR518B Gene

Function for MIR518B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518B Gene

Localization for MIR518B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR518B Gene

Pathways & Interactions for MIR518B Gene

SuperPathways for MIR518B Gene

No Data Available

Interacting Proteins for MIR518B Gene

Gene Ontology (GO) - Biological Process for MIR518B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR518B Gene

Drugs & Compounds for MIR518B Gene

No Compound Related Data Available

Transcripts for MIR518B Gene

mRNA/cDNA for MIR518B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518B Gene

No ASD Table

Relevant External Links for MIR518B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR518B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR518B Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518B Gene

Orthologs for MIR518B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR518B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-518b 35
  • 100 (a)
Species where no ortholog for MIR518B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR518B Gene

Gene Tree for MIR518B (if available)
Gene Tree for MIR518B (if available)

Paralogs for MIR518B Gene

No data available for Paralogs for MIR518B Gene

Variants for MIR518B Gene

Sequence variations from dbSNP and Humsavar for MIR518B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000787775 -- 53,701,307(+) AAGCA(A/G)CGTTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001044145 -- 53,702,879(+) TTATC(A/G)TCAGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001093577 -- 53,703,021(+) TTTTA(A/G)TTGTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002526327 -- 53,701,848(+) TCTGG(C/T)GCTAT intron-variant, upstream-variant-2KB
rs1002589013 -- 53,701,554(+) GCATG(A/C)TTTGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR518B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR518B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR518B Gene

Disorders for MIR518B Gene

Relevant External Links for MIR518B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR518B Gene

Publications for MIR518B Gene

  1. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation. (PMID: 26040940) Hasegawa Y. … Masuzaki H. (Reprod Sci 2015) 3 64
  2. Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. (PMID: 24173143) Liang W. … Liao L. (Int. J. Oncol. 2014) 3 64
  3. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R. … Chaganti R.S. (Stem Cells Dev. 2014) 3 64
  4. Underexpression of 4 placenta-associated microRNAs in complete hydatidiform moles. (PMID: 22672989) Na Q. … Song W. (Int. J. Gynecol. Cancer 2012) 3 64
  5. miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma. (PMID: 22958893) Zhang M. … Wang J. (FEBS Lett. 2012) 3 64

Products for MIR518B Gene

Sources for MIR518B Gene

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