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Aliases for MIR518B Gene

Subcategory (RNA class) for MIR518B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR518B Gene

  • MicroRNA 518b 2 3 5
  • Hsa-Mir-518b 3
  • Mir-518b 3
  • MIRN518B 3

External Ids for MIR518B Gene

ORGUL Members for MIR518B Gene

Previous HGNC Symbols for MIR518B Gene

  • MIRN518B

Previous GeneCards Identifiers for MIR518B Gene

  • GC19P058925
  • GC19P058997
  • GC19P054205
  • GC19P053705
  • GC19P053735
  • GC19P053768
  • GC19P053802
  • GC19P053838
  • GC19P053847

Summaries for MIR518B Gene

Entrez Gene Summary for MIR518B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518B Gene

MIR518B (MicroRNA 518b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR518B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR518B Gene

Genomics for MIR518B Gene

Regulatory Elements for MIR518B Gene

Enhancers for MIR518B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H053840 1.2 Ensembl ENCODE 10.5 +139.4 139392 2 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19H053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +142.4 142357 0 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19H053659 1 ENCODE dbSUPER 11.1 -41.5 -41462 2 ELF3 SOX5 SOX13 GATAD2A SAP130 SP5 PPARG ETV4 CREB1 POU5F1 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19H053611 1 ENCODE dbSUPER 10.8 -89.8 -89772 3 SOX13 ESRRA FOXA2 TEAD3 CTBP1 GATA3 POLR2A NR2F6 SMARCE1 SOX5 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C MIR526A1
GH19H053898 0.9 Ensembl ENCODE 10.6 +196.1 196106 1 PKNOX1 MAZ SP3 KLF1 ZNF740 SP2 REST SP1 POLR2A PATZ1 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A MIR516A2 RNU6-1041P MIR519A1 RNU6-751P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR518B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR518B Gene

Chromosome:
19
Start:
53,702,737 bp from pter
End:
53,702,819 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR518B Gene

Genes around MIR518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518B Gene

Proteins for MIR518B Gene

Post-translational modifications for MIR518B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518B Gene

Domains & Families for MIR518B Gene

Gene Families for MIR518B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR518B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR518B Gene

Function for MIR518B Gene

Gene Ontology (GO) - Molecular Function for MIR518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22958893
genes like me logo Genes that share ontologies with MIR518B: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR518B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518B Gene

Localization for MIR518B Gene

Gene Ontology (GO) - Cellular Components for MIR518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR518B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR518B Gene

Pathways & Interactions for MIR518B Gene

SuperPathways for MIR518B Gene

No Data Available

Interacting Proteins for MIR518B Gene

Gene Ontology (GO) - Biological Process for MIR518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 22958893
GO:0030336 negative regulation of cell migration IDA 22958893
GO:0030857 negative regulation of epithelial cell differentiation IMP 24383669
GO:0035195 gene silencing by miRNA IDA 24383669
GO:0035278 miRNA mediated inhibition of translation IDA 22958893
genes like me logo Genes that share ontologies with MIR518B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR518B Gene

Drugs & Compounds for MIR518B Gene

No Compound Related Data Available

Transcripts for MIR518B Gene

mRNA/cDNA for MIR518B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR518B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518B Gene

No ASD Table

Relevant External Links for MIR518B Gene

GeneLoc Exon Structure for
MIR518B
ECgene alternative splicing isoforms for
MIR518B

Expression for MIR518B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR518B Gene:

MIR518B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518B Gene

Orthologs for MIR518B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR518B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-518b 34
  • 100 (a)
OneToOne
Species where no ortholog for MIR518B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR518B Gene

ENSEMBL:
Gene Tree for MIR518B (if available)
TreeFam:
Gene Tree for MIR518B (if available)

Paralogs for MIR518B Gene

No data available for Paralogs for MIR518B Gene

Variants for MIR518B Gene

Sequence variations from dbSNP and Humsavar for MIR518B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000787775 -- 53,701,307(+) AAGCA(A/G)CGTTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001044145 -- 53,702,879(+) TTATC(A/G)TCAGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001093577 -- 53,703,021(+) TTTTA(A/G)TTGTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002526327 -- 53,701,848(+) TCTGG(C/T)GCTAT intron-variant, upstream-variant-2KB
rs1002589013 -- 53,701,554(+) GCATG(A/C)TTTGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR518B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR518B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR518B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR518B Gene

Disorders for MIR518B Gene

Relevant External Links for MIR518B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR518B

No disorders were found for MIR518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR518B Gene

Publications for MIR518B Gene

  1. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation. (PMID: 26040940) Hasegawa Y … Masuzaki H (Reproductive sciences (Thousand Oaks, Calif.) 2015) 3 60
  2. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R … Chaganti RS (Stem cells and development 2014) 3 60
  3. Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. (PMID: 24173143) Liang W … Liao L (International journal of oncology 2014) 3 60
  4. miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma. (PMID: 22958893) Zhang M … Wang J (FEBS letters 2012) 3 60
  5. Underexpression of 4 placenta-associated microRNAs in complete hydatidiform moles. (PMID: 22672989) Na Q … Song W (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2012) 3 60

Products for MIR518B Gene

Sources for MIR518B Gene

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