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Aliases for MIR518B Gene

Subcategory (RNA class) for MIR518B Gene


Quality Score for this RNA gene is


Aliases for MIR518B Gene

  • MicroRNA 518b 2 3 5
  • Hsa-Mir-518b 3
  • Mir-518b 3
  • MIRN518B 3

External Ids for MIR518B Gene

ORGUL Members for MIR518B Gene

Previous HGNC Symbols for MIR518B Gene

  • MIRN518B

Previous GeneCards Identifiers for MIR518B Gene

  • GC19P058925
  • GC19P058997
  • GC19P054205
  • GC19P053705
  • GC19P053735

Summaries for MIR518B Gene

Entrez Gene Summary for MIR518B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518B Gene

MIR518B (MicroRNA 518b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR518B Gene

Genomics for MIR518B Gene

Genomic Location for MIR518B Gene

53,702,737 bp from pter
53,702,819 bp from pter
83 bases
Plus strand

Genomic View for MIR518B Gene

Genes around MIR518B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518B Gene

No data available for Regulatory Elements for MIR518B Gene

Proteins for MIR518B Gene

Post-translational modifications for MIR518B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518B Gene

Domains & Families for MIR518B Gene

Gene Families for MIR518B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR518B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR518B Gene

Function for MIR518B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518B Gene

Localization for MIR518B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR518B Gene

Pathways & Interactions for MIR518B Gene

SuperPathways for MIR518B Gene

No Data Available

Interacting Proteins for MIR518B Gene

Gene Ontology (GO) - Biological Process for MIR518B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR518B Gene

Drugs & Compounds for MIR518B Gene

No Compound Related Data Available

Transcripts for MIR518B Gene

mRNA/cDNA for MIR518B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518B Gene

No ASD Table

Relevant External Links for MIR518B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR518B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR518B Gene

Orthologs for MIR518B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR518B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-518b 36
  • 100 (a)
Species with no ortholog for MIR518B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR518B Gene

Gene Tree for MIR518B (if available)
Gene Tree for MIR518B (if available)

Paralogs for MIR518B Gene

No data available for Paralogs for MIR518B Gene

Variants for MIR518B Gene

Sequence variations from dbSNP and Humsavar for MIR518B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8106684 -- 53,702,959(+) gagtg(C/T)ggtgg downstream-variant-500B
rs72530629 -- 53,702,721(+) CAGTG(-/T)TGGAG upstream-variant-2KB
rs140946492 -- 53,702,881(+) ATCAT(C/T)AGACG downstream-variant-500B
rs1865044 -- 53,702,282(-) GAGGC(A/G)GAGGT upstream-variant-2KB
rs1865045 -- 53,702,149(-) TAGAC(C/T)ACTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR518B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718836 CNV Deletion 23290073

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR518B Gene

Disorders for MIR518B Gene

Relevant External Links for MIR518B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR518B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR518B Gene

Publications for MIR518B Gene

  1. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R. … Chaganti R.S. (Stem Cells Dev. 2014) 3 67
  2. Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. (PMID: 24173143) Liang W. … Liao L. (Int. J. Oncol. 2014) 3
  3. Underexpression of 4 placenta-associated microRNAs in complete hydatidiform moles. (PMID: 22672989) Na Q. … Song W. (Int. J. Gynecol. Cancer 2012) 3
  4. miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma. (PMID: 22958893) Zhang M. … Wang J. (FEBS Lett. 2012) 3
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3

Products for MIR518B Gene

Sources for MIR518B Gene