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Aliases for MIR518A2 Gene

Subcategory (RNA class) for MIR518A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR518A2 Gene

  • MicroRNA 518a-2 2 3
  • Hsa-Mir-518a-2 3
  • MIRN518A-2 3
  • MIRN518A2 3

External Ids for MIR518A2 Gene

ORGUL Members for MIR518A2 Gene

Previous HGNC Symbols for MIR518A2 Gene

  • MIRN518A-2
  • MIRN518A2

Previous GeneCards Identifiers for MIR518A2 Gene

  • GC19P058973
  • GC19P059017
  • GC19P054242

Summaries for MIR518A2 Gene

Entrez Gene Summary for MIR518A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518A2 Gene

MIR518A2 (MicroRNA 518a-2) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR518A2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR518A2

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR518A2 Gene

Genomics for MIR518A2 Gene

Genomic Location for MIR518A2 Gene

Start:
53,739,333 bp from pter
End:
53,739,419 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR518A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR518A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518A2 Gene

ORGUL Member Location for MIR518A2 Gene

ORGUL Member Location for MIR518A2 gene

No data available for Regulatory Elements for MIR518A2 Gene

Proteins for MIR518A2 Gene

Post-translational modifications for MIR518A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518A2 Gene

Domains for MIR518A2 Gene

Gene Families for MIR518A2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR518A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR518A2 Gene

Function for MIR518A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR518A2 Gene

Localization for MIR518A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR518A2 Gene

Pathways for MIR518A2 Gene

SuperPathways for MIR518A2 Gene

No Data Available

Interacting Proteins for MIR518A2 Gene

Gene Ontology (GO) - Biological Process for MIR518A2 Gene

None

No data available for Pathways by source for MIR518A2 Gene

Transcripts for MIR518A2 Gene

fRNAdb Secondary structures for MIR518A2 Gene

  • FR080555
  • FR272499

mRNA/cDNA for MIR518A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518A2 Gene

No ASD Table

Relevant External Links for MIR518A2 Gene

GeneLoc Exon Structure for
MIR518A2
ECgene alternative splicing isoforms for
MIR518A2

Expression for MIR518A2 Gene

mRNA expression in normal human tissues for MIR518A2 Gene

genes like me logo Genes that share expressions with MIR518A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR518A2 Gene

Orthologs for MIR518A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR518A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-518a 36
  • 95 (a)
OneToOne
Species with no ortholog for MIR518A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR518A2 Gene

ENSEMBL:
Gene Tree for MIR518A2 (if available)
TreeFam:
Gene Tree for MIR518A2 (if available)

Paralogs for MIR518A2 Gene

No data available for Paralogs for MIR518A2 Gene

Variants for MIR518A2 Gene

Sequence variations from dbSNP and Humsavar for MIR518A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs305929 -- 53,738,731(+) tgcgc(C/T)accac upstream-variant-2KB
rs4803171 -- 53,738,643(+) GGCAC(A/G)ATCTT upstream-variant-2KB
rs8107360 -- 53,738,438(+) GACTC(C/T)TATCT upstream-variant-2KB
rs10407790 -- 53,737,554(+) gccac(C/T)gcacc upstream-variant-2KB
rs10413439 -- 53,737,727(+) tcttc(A/C)accca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR518A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718837 CNV Deletion 23290073
esv2448351 CNV Deletion 19546169
esv2718838 CNV Deletion 23290073

Relevant External Links for MIR518A2 Gene

HapMap Linkage Disequilibrium report
MIR518A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR518A2 Gene

Disorders for MIR518A2 Gene

No disorders were found for MIR518A2 Gene.

No data available for UniProtKB/Swiss-Prot for MIR518A2 Gene

Publications for MIR518A2 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Chemokine receptor CCR6 expression is regulated by miR-518a-5p in colorectal cancer cells. (PMID: 24559209) Rubie C. … Glanemann M. (J Transl Med 2014) 3

Products for MIR518A2 Gene

Sources for MIR518A2 Gene

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