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Aliases for MIR5189 Gene

Subcategory (RNA class) for MIR5189 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5189 Gene

  • MicroRNA 5189 2 3 5
  • Hsa-Mir-5189 3
  • Mir-5189 3

External Ids for MIR5189 Gene

Previous GeneCards Identifiers for MIR5189 Gene

  • GC16U901385

Summaries for MIR5189 Gene

Entrez Gene Summary for MIR5189 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5189 Gene

MIR5189 (MicroRNA 5189) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5189 Gene

Genomics for MIR5189 Gene

Regulatory Elements for MIR5189 Gene

Enhancers for MIR5189 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G088468 1.6 FANTOM5 ENCODE dbSUPER 0.7 +2.5 2544 6.2 PKNOX1 AGO1 ZFP64 SIN3A E2F7 YY1 TCF12 ZNF121 GLIS2 GATA2 RNF166 ZFPM1 LOC100128882 ZC3H18 APRT CTU2 ZNF469 SNAI3 PIEZO1 MIR5189
GH16G088464 1.4 Ensembl ENCODE dbSUPER 0.7 -4.2 -4194 2.1 HDAC1 PTBP1 AGO1 TCF12 ZNF766 GATA2 EGR2 MIER1 REST KLF16 ZFPM1 LOC100128882 MIR5189
GH16G088452 1.8 FANTOM5 ENCODE dbSUPER 0.4 -14.0 -13982 6.0 MLX AGO1 DMAP1 YBX1 SLC30A9 ZNF143 SP3 TBX21 GLIS1 NBN ENSG00000259877 RNF166 ZFPM1 ENSG00000268218 ENSG00000260121 ZCCHC14 ZC3H18 SNAI3 MIR5189
GH16G088459 1.6 Ensembl ENCODE dbSUPER 0.4 -7.6 -7561 3.0 HDGF PKNOX1 AGO1 ARID4B ZNF143 ZNF263 TAF15 REST ZNF592 ZNF579 ENSG00000268218 ZNF778 ZFPM1 MIR5189
GH16G088466 0.9 Ensembl dbSUPER 0.7 -2.3 -2338 0.4 BCOR SMARCA5 CTCF PTBP1 ZMYM3 NFXL1 ATF2 JUND GLIS2 HDAC2 MIR5189 ZFPM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5189 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5189 Gene

Chromosome:
16
Start:
88,468,918 bp from pter
End:
88,469,031 bp from pter
Size:
114 bases
Orientation:
Plus strand

Genomic View for MIR5189 Gene

Genes around MIR5189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5189 Gene

Proteins for MIR5189 Gene

Post-translational modifications for MIR5189 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5189 Gene

Domains & Families for MIR5189 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5189 Gene

Function for MIR5189 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5189 Gene

Localization for MIR5189 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR5189 Gene

Pathways & Interactions for MIR5189 Gene

SuperPathways for MIR5189 Gene

No Data Available

Interacting Proteins for MIR5189 Gene

Gene Ontology (GO) - Biological Process for MIR5189 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5189 Gene

Drugs & Compounds for MIR5189 Gene

No Compound Related Data Available

Transcripts for MIR5189 Gene

mRNA/cDNA for MIR5189 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5189 Gene

No ASD Table

Relevant External Links for MIR5189 Gene

GeneLoc Exon Structure for
MIR5189
ECgene alternative splicing isoforms for
MIR5189

Expression for MIR5189 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR5189 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5189 Gene:

MIR5189
genes like me logo Genes that share expression patterns with MIR5189: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5189 Gene

Orthologs for MIR5189 Gene

Evolution for MIR5189 Gene

ENSEMBL:
Gene Tree for MIR5189 (if available)
TreeFam:
Gene Tree for MIR5189 (if available)

No data available for Orthologs for MIR5189 Gene

Paralogs for MIR5189 Gene

No data available for Paralogs for MIR5189 Gene

Variants for MIR5189 Gene

Sequence variations from dbSNP and Humsavar for MIR5189 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1003723896 -- 88,468,534(+) CACTC(A/G)GAGTC intron-variant, upstream-variant-2KB
rs1004096185 -- 88,468,842(+) TTGAC(C/T)TGGGG intron-variant, upstream-variant-2KB
rs1004846062 -- 88,468,880(+) CAGGA(C/T)GGGAG intron-variant, upstream-variant-2KB
rs1005345784 -- 88,468,224(+) CCGCC(C/T)CTCAA intron-variant, upstream-variant-2KB
rs1005917467 -- 88,468,403(+) AAAAT(A/G)AGAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR5189 Gene

Variant ID Type Subtype PubMed ID
dgv171n21 CNV loss 19592680
dgv5293n54 CNV loss 21841781
esv2758669 CNV gain 17122850
nsv1061590 CNV gain 25217958
nsv471111 CNV loss 18288195
nsv471112 CNV gain 18288195
nsv528456 CNV loss 19592680
nsv817747 CNV loss 17921354
nsv952070 CNV deletion 24416366

Relevant External Links for MIR5189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5189 Gene

Disorders for MIR5189 Gene

Relevant External Links for MIR5189

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5189

No disorders were found for MIR5189 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5189 Gene

Publications for MIR5189 Gene

  1. The repertoire and features of human platelet microRNAs. (PMID: 23226537) PlAc H. … Provost P. (PLoS ONE 2012) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5189 Gene

Sources for MIR5189 Gene

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