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Aliases for MIR5187 Gene

Subcategory (RNA class) for MIR5187 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5187 Gene

  • MicroRNA 5187 2 3
  • TOMM40L 4 5
  • Translocase Of Outer Mitochondrial Membrane 40 Like 5
  • Protein TOMM40-Like 4
  • Hsa-Mir-5187 3
  • Mir-5187 3
  • TOMM40B 4

External Ids for MIR5187 Gene

Previous GeneCards Identifiers for MIR5187 Gene

  • GC01U903353
  • GC01P161199

Summaries for MIR5187 Gene

Entrez Gene Summary for MIR5187 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5187 Gene

MIR5187 (MicroRNA 5187) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is TOMM40.

UniProtKB/Swiss-Prot for MIR5187 Gene

  • Potential channel-forming protein implicated in import of protein precursors into mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5187 Gene

Genomics for MIR5187 Gene

Regulatory Elements for MIR5187 Gene

Enhancers for MIR5187 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F161256 0.6 ENCODE 11.9 +30.3 30347 0.2 PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF766 SP3 YY2 APOA2 MIR5187 TOMM40L SDHC PCP4L1 NR1I3
GH01F161381 1.5 FANTOM5 Ensembl ENCODE 11.6 +156.8 156811 2.3 CTCF ZNF654 CEBPB MAFG REST RAD21 RFX5 ZNF316 ZBTB48 SMC3 SDHC NR1I3 MIR5187 TOMM40L APOA2 ADAMTS4 NDUFS2 MPZ RRM2P2 ENSG00000283696
GH01F161378 0.5 FANTOM5 11.6 +153.3 153271 0.5 POLR2A ZBTB33 NDUFS2 NR1I3 APOA2 MIR5187 TOMM40L ADAMTS4 SDHC MPZ RRM2P2 CFAP126
GH01F161304 0.2 ENCODE 11.4 +80.5 80514 3.0 HDGF TBP HDAC1 ATF1 PKNOX1 CBX3 CREB3L1 RAD21 ZBTB40 YY1 FCER1G NDUFS2 NR1I3 MIR5187 TOMM40L APOA2 PCP4L1 SDHC FCGR2C MPZ
GH01F161359 1.4 FANTOM5 ENCODE 11.3 +133.5 133531 0.9 SDHC MPZ NR1I3 APOA2 MIR5187 TOMM40L FCER1G CD244 ATF6 FCRLB
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR5187 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5187 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000546434 361 1401 PKNOX1 ATF1 ARID4B SIN3A GLI4 ZNF48 ZNF2 ETS1 YY1 ZNF207

Genomic Location for MIR5187 Gene

Chromosome:
1
Start:
161,225,939 bp from pter
End:
161,230,744 bp from pter
Size:
4,806 bases
Orientation:
Plus strand

Genomic View for MIR5187 Gene

Genes around MIR5187 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5187 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5187 Gene

Proteins for MIR5187 Gene

  • Protein details for MIR5187 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M1-TM40L_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM40B
    Protein Accession:
    Q969M1
    Secondary Accessions:
    • B7Z4U0
    • D3DVG9

    Protein attributes for MIR5187 Gene

    Size:
    308 amino acids
    Molecular mass:
    33917 Da
    Quaternary structure:
    • Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).
    • Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).

    Alternative splice isoforms for MIR5187 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR5187 Gene

Post-translational modifications for MIR5187 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR5187 Gene

No data available for DME Specific Peptides for MIR5187 Gene

Domains & Families for MIR5187 Gene

Protein Domains for MIR5187 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q969M1

UniProtKB/Swiss-Prot:

TM40L_HUMAN :
  • Belongs to the Tom40 family.
Family:
  • Belongs to the Tom40 family.
genes like me logo Genes that share domains with MIR5187: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5187 Gene

Function for MIR5187 Gene

Molecular function for MIR5187 Gene

UniProtKB/Swiss-Prot Function:
Potential channel-forming protein implicated in import of protein precursors into mitochondria.

Gene Ontology (GO) - Molecular Function for MIR5187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015266 protein channel activity IBA --
GO:0015288 porin activity IEA --
genes like me logo Genes that share ontologies with MIR5187: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5187 Gene

Localization for MIR5187 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5187 Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR5187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005742 mitochondrial outer membrane translocase complex IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR5187: view

No data available for Subcellular locations from COMPARTMENTS for MIR5187 Gene

Pathways & Interactions for MIR5187 Gene

SuperPathways for MIR5187 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0030150 protein import into mitochondrial matrix IBA --
genes like me logo Genes that share ontologies with MIR5187: view

No data available for Pathways by source and SIGNOR curated interactions for MIR5187 Gene

Transcripts for MIR5187 Gene

mRNA/cDNA for MIR5187 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5187 Gene

No ASD Table

Relevant External Links for MIR5187 Gene

GeneLoc Exon Structure for
MIR5187
ECgene alternative splicing isoforms for
MIR5187

Expression for MIR5187 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5187 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5187 Gene:

MIR5187
genes like me logo Genes that share expression patterns with MIR5187: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5187 Gene

Orthologs for MIR5187 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR5187 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM40L 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tomm40l 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM40L 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOMM40L 35
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TOM40B 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM40L 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TOMM40L 35
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tomboy40 35
  • 39 (a)
ManyToMany
Tom40 35
  • 37 (a)
ManyToMany
CG4520 35
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tomm-40 35
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM40 35 37
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2065 35
  • 37 (a)
OneToMany
Species where no ortholog for MIR5187 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MIR5187 Gene

ENSEMBL:
Gene Tree for MIR5187 (if available)
TreeFam:
Gene Tree for MIR5187 (if available)

Paralogs for MIR5187 Gene

Paralogs for MIR5187 Gene

genes like me logo Genes that share paralogs with MIR5187: view

Variants for MIR5187 Gene

Sequence variations from dbSNP and Humsavar for MIR5187 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111536768 -- 161,225,658(+) TCCAC(G/T)TTTCT upstream-variant-2KB
rs111822601 -- 161,226,904(+) GCACA(A/G)ATGGA upstream-variant-2KB, reference, synonymous-codon
rs112674232 -- 161,227,192(+) ACTAA(A/C/G)GGTGG intron-variant, nc-transcript-variant
rs112684204 -- 161,225,337(+) AGCTG(A/C/T)TTCAG upstream-variant-2KB
rs113649867 -- 161,226,050(+) AGCTG(C/T)AGTTC upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR5187 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5187

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5187 Gene

Disorders for MIR5187 Gene

Relevant External Links for MIR5187

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5187

No disorders were found for MIR5187 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5187 Gene

Publications for MIR5187 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64
  4. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce C.E. … Bowcock A.M. (Hum. Mol. Genet. 2011) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for MIR5187 Gene

Sources for MIR5187 Gene

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