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Aliases for MIR5186 Gene

Subcategory (RNA class) for MIR5186 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5186 Gene

  • MicroRNA 5186 2 3 5
  • Hsa-Mir-5186 3

External Ids for MIR5186 Gene

Previous GeneCards Identifiers for MIR5186 Gene

  • GC03U901832
  • GC03M151285

Summaries for MIR5186 Gene

Entrez Gene Summary for MIR5186 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5186 Gene

MIR5186 (MicroRNA 5186) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5186 Gene

Genomics for MIR5186 Gene

Regulatory Elements for MIR5186 Gene

Enhancers for MIR5186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G151580 0.8 Ensembl ENCODE 0.4 -14.7 -14727 0.2 PKNOX1 JUND STAT3 CEBPB ZSCAN29 EP300 MIR5186 IGSF10
GH03G151568 0.4 ENCODE 0.7 -2.4 -2393 0.2 PKNOX1 ATF2 MIR5186 IGSF10
GH03G151544 0.8 ENCODE 0.3 +22.3 22298 0.1 SOX13 NFIB BACH1 ZNF316 NFE2 FOS MAFK NFE2L2 TCF7L2 SOX5 LINC02066 IGSF10 MIR5186 ENSG00000242119
GH03G151537 0.8 Ensembl ENCODE 0.3 +27.6 27550 2.1 RNF2 L3MBTL2 GATA2 MGA ZNF592 LINC02066 IGSF10 MIR5186 ENSG00000242119
GH03G151543 0.7 Ensembl 0.3 +22.5 22494 0.2 SOX13 NFIB BACH1 ZNF316 FOS NFE2 TCF7L2 SOX5 NFIA HLF LINC02066 MIR5186 ENSG00000242119
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5186 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5186 Gene

Chromosome:
3
Start:
151,565,876 bp from pter
End:
151,565,995 bp from pter
Size:
120 bases
Orientation:
Minus strand

Genomic View for MIR5186 Gene

Genes around MIR5186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5186 Gene

Proteins for MIR5186 Gene

Post-translational modifications for MIR5186 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5186 Gene

Domains & Families for MIR5186 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5186 Gene

Function for MIR5186 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5186 Gene

Localization for MIR5186 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR5186 Gene

Pathways & Interactions for MIR5186 Gene

SuperPathways for MIR5186 Gene

No Data Available

Interacting Proteins for MIR5186 Gene

Gene Ontology (GO) - Biological Process for MIR5186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5186 Gene

Transcripts for MIR5186 Gene

mRNA/cDNA for MIR5186 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5186 Gene

No ASD Table

Relevant External Links for MIR5186 Gene

GeneLoc Exon Structure for
MIR5186
ECgene alternative splicing isoforms for
MIR5186

Expression for MIR5186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR5186 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5186 Gene:

MIR5186
genes like me logo Genes that share expression patterns with MIR5186: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5186 Gene

Orthologs for MIR5186 Gene

Evolution for MIR5186 Gene

ENSEMBL:
Gene Tree for MIR5186 (if available)
TreeFam:
Gene Tree for MIR5186 (if available)

No data available for Orthologs for MIR5186 Gene

Paralogs for MIR5186 Gene

No data available for Paralogs for MIR5186 Gene

Variants for MIR5186 Gene

Sequence variations from dbSNP and Humsavar for MIR5186 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1003455426 -- 151,566,745(+) CATTC(A/G)GTACT intron-variant, upstream-variant-2KB
rs1003552829 -- 151,566,100(+) GTGAG(A/G)CCCTA intron-variant, upstream-variant-2KB
rs1006720565 -- 151,567,001(+) CAGGT(A/G)GCTGT intron-variant, upstream-variant-2KB
rs1006807341 -- 151,567,419(+) GGGTG(C/T)ATAGT intron-variant, upstream-variant-2KB
rs1006815449 -- 151,566,812(+) ATTTC(C/T)TCAAT intron-variant, upstream-variant-2KB

Relevant External Links for MIR5186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5186 Gene

Disorders for MIR5186 Gene

Relevant External Links for MIR5186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5186

No disorders were found for MIR5186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5186 Gene

Publications for MIR5186 Gene

  1. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D. … den Boer M.L. (Leukemia 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5186 Gene

Sources for MIR5186 Gene

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