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Aliases for MIR517C Gene

Subcategory (RNA class) for MIR517C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR517C Gene

  • MicroRNA 517c 2 3
  • Hsa-Mir-517c 3
  • MIRN517C 3

External Ids for MIR517C Gene

ORGUL Members for MIR517C Gene

Previous HGNC Symbols for MIR517C Gene

  • MIRN517C

Previous GeneCards Identifiers for MIR517C Gene

  • GC19P058975
  • GC19P059018
  • GC19P054247
  • GC19P054250
  • GC19P054300
  • GC19P054328
  • GC19P054348
  • GC19P054420
  • GC19P054501

Summaries for MIR517C Gene

Entrez Gene Summary for MIR517C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517C Gene

MIR517C (MicroRNA 517c) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR517C Gene

Genomics for MIR517C Gene

Genomic Location for MIR517C Gene

Start:
53,741,313 bp from pter
End:
53,741,407 bp from pter
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR517C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR517C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR517C Gene

No data available for Regulatory Elements for MIR517C Gene

Proteins for MIR517C Gene

Post-translational modifications for MIR517C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517C Gene

Domains for MIR517C Gene

Gene Families for MIR517C Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR517C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR517C Gene

Function for MIR517C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR517C Gene

Localization for MIR517C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR517C Gene

Pathways for MIR517C Gene

SuperPathways for MIR517C Gene

No Data Available

Interacting Proteins for MIR517C Gene

Gene Ontology (GO) - Biological Process for MIR517C Gene

None

No data available for Pathways by source for MIR517C Gene

Transcripts for MIR517C Gene

mRNA/cDNA for MIR517C Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517C Gene

No ASD Table

Relevant External Links for MIR517C Gene

GeneLoc Exon Structure for
MIR517C
ECgene alternative splicing isoforms for
MIR517C

Expression for MIR517C Gene

mRNA expression in normal human tissues for MIR517C Gene

genes like me logo Genes that share expressions with MIR517C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR517C Gene

Orthologs for MIR517C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-517b-2 36
  • 99 (a)
OneToOne
Species with no ortholog for MIR517C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR517C Gene

ENSEMBL:
Gene Tree for MIR517C (if available)
TreeFam:
Gene Tree for MIR517C (if available)

Paralogs for MIR517C Gene

No data available for Paralogs for MIR517C Gene

Variants for MIR517C Gene

Sequence variations from dbSNP and Humsavar for MIR517C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8108415 -- 53,740,470(+) gccct(C/G)cccag upstream-variant-2KB
rs28505794 -- 53,740,045(+) ATGCG(C/T)CCCCA upstream-variant-2KB
rs59087537 -- 53,740,233(+) GCACT(A/G)GTTTA upstream-variant-2KB
rs73055530 -- 53,740,007(+) TCATC(C/T)GCCCA upstream-variant-2KB
rs112304511 -- 53,740,146(+) TGCCT(C/T)GGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR517C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718837 CNV Deletion 23290073
esv2448351 CNV Deletion 19546169
esv2718838 CNV Deletion 23290073

Relevant External Links for MIR517C Gene

HapMap Linkage Disequilibrium report
MIR517C

PCR Panel Products

  • Copy Number PCR Panels: for MIR517C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR517C Gene

Disorders for MIR517C Gene

No disorders were found for MIR517C Gene.

No data available for UniProtKB/Swiss-Prot for MIR517C Gene

Publications for MIR517C Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. (PMID: 19962671) Li M. … Huang A. (Cancer Cell 2009) 3
  5. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. (PMID: 23142219) Liu R.F. … Han Z.G. (Cancer Lett. 2013) 3

Products for MIR517C Gene

Sources for MIR517C Gene

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