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Aliases for MIR517C Gene

Subcategory (RNA class) for MIR517C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR517C Gene

  • MicroRNA 517c 2 3 5
  • Hsa-Mir-517c 3
  • MIRN517C 3

External Ids for MIR517C Gene

ORGUL Members for MIR517C Gene

Previous HGNC Symbols for MIR517C Gene

  • MIRN517C

Previous GeneCards Identifiers for MIR517C Gene

  • GC19P058975
  • GC19P059018
  • GC19P054247
  • GC19P054250
  • GC19P054300
  • GC19P054328
  • GC19P054348
  • GC19P054420
  • GC19P054501
  • GC19P053742
  • GC19P053771
  • GC19P053805
  • GC19P053832
  • GC19P053856
  • GC19P053871

Summaries for MIR517C Gene

Entrez Gene Summary for MIR517C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517C Gene

MIR517C (MicroRNA 517c) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR517C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR517C Gene

Genomics for MIR517C Gene

Regulatory Elements for MIR517C Gene

Enhancers for MIR517C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H053840 1.2 Ensembl ENCODE 10.5 +100.8 100816 2 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19H053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +103.8 103781 0 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19H053659 1 ENCODE dbSUPER 11 -80.0 -80038 2 ELF3 SOX5 SOX13 GATAD2A SAP130 SP5 PPARG ETV4 CREB1 POU5F1 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19H053611 1 ENCODE dbSUPER 10.8 -128.3 -128348 3 SOX13 ESRRA FOXA2 TEAD3 CTBP1 GATA3 POLR2A NR2F6 SMARCE1 SOX5 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C MIR526A1
GH19H053898 0.9 Ensembl ENCODE 10.6 +157.5 157530 1 PKNOX1 MAZ SP3 KLF1 ZNF740 SP2 REST SP1 POLR2A PATZ1 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A MIR516A2 RNU6-1041P MIR519A1 RNU6-751P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR517C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR517C Gene

Chromosome:
19
Start:
53,741,313 bp from pter
End:
53,741,407 bp from pter
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR517C Gene

Genes around MIR517C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR517C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR517C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR517C Gene

Proteins for MIR517C Gene

Post-translational modifications for MIR517C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517C Gene

Domains & Families for MIR517C Gene

Gene Families for MIR517C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR517C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR517C Gene

Function for MIR517C Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR517C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR517C Gene

Localization for MIR517C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR517C Gene

Pathways & Interactions for MIR517C Gene

SuperPathways for MIR517C Gene

No Data Available

Interacting Proteins for MIR517C Gene

Gene Ontology (GO) - Biological Process for MIR517C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR517C Gene

Drugs & Compounds for MIR517C Gene

No Compound Related Data Available

Transcripts for MIR517C Gene

mRNA/cDNA for MIR517C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR517C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517C Gene

No ASD Table

Relevant External Links for MIR517C Gene

GeneLoc Exon Structure for
MIR517C
ECgene alternative splicing isoforms for
MIR517C

Expression for MIR517C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR517C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR517C Gene:

MIR517C
genes like me logo Genes that share expression patterns with MIR517C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR517C Gene

Orthologs for MIR517C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-517b-2 34
  • 99 (a)
OneToOne
Species where no ortholog for MIR517C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR517C Gene

ENSEMBL:
Gene Tree for MIR517C (if available)
TreeFam:
Gene Tree for MIR517C (if available)

Paralogs for MIR517C Gene

No data available for Paralogs for MIR517C Gene

Variants for MIR517C Gene

Sequence variations from dbSNP and Humsavar for MIR517C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001851155 -- 53,739,666(+) ACCCC(A/C)GCCTC downstream-variant-500B, upstream-variant-2KB
rs1001888982 -- 53,739,832(+) ATCTC(A/G)GCTCA downstream-variant-500B, upstream-variant-2KB
rs1002430889 -- 53,741,240(+) CGACT(C/G)CATCT upstream-variant-2KB
rs1003501314 -- 53,740,460(+) CCTGC(C/T)TCTGG upstream-variant-2KB
rs1004005488 -- 53,739,805(+) TCACC(C/T)ATGCT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR517C Gene

Variant ID Type Subtype PubMed ID
esv2448351 CNV deletion 19546169
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
esv2718838 CNV deletion 23290073
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR517C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR517C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR517C Gene

Disorders for MIR517C Gene

Relevant External Links for MIR517C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR517C

No disorders were found for MIR517C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR517C Gene

Publications for MIR517C Gene

  1. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. (PMID: 25799546) Anton L … Elovitz MA (PloS one 2015) 3 60
  2. MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. (PMID: 26553592) Lu Y … Qi S (Autophagy 2015) 3 60
  3. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. (PMID: 23142219) Liu RF … Han ZG (Cancer letters 2013) 3 60
  4. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. (PMID: 19962671) Li M … Huang A (Cancer cell 2009) 3 60
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 60

Products for MIR517C Gene

Sources for MIR517C Gene

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