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Aliases for MIR517B Gene

Subcategory (RNA class) for MIR517B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR517B Gene

  • MicroRNA 517b 2 3 5
  • Hsa-Mir-517b 3
  • Mir-517b 3
  • MIRN517B 3

External Ids for MIR517B Gene

ORGUL Members for MIR517B Gene

Previous HGNC Symbols for MIR517B Gene

  • MIRN517B

Previous GeneCards Identifiers for MIR517B Gene

  • GC19P058945
  • GC19P059008
  • GC19P054229
  • GC19P054237
  • GC19P054273
  • GC19P054322
  • GC19P054343
  • GC19P054414
  • GC19P054489

Summaries for MIR517B Gene

Entrez Gene Summary for MIR517B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517B Gene

MIR517B (MicroRNA 517b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR517B Gene

Genomics for MIR517B Gene

Regulatory Elements for MIR517B Gene

Enhancers for MIR517B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053611 1.2 ENCODE 10.8 -108.1 -108111 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF765 CDC42EP5 ENSG00000269288 ZNF347 PRPF31 MIR520A ZNF665 RNU6-698P MIR519B MIR525
GH19F053840 1.2 Ensembl ENCODE 10.5 +121.5 121525 4.0 PKNOX1 ARID4B SIN3A YBX1 ZNF121 FOS SP3 JUNB REST TBX21 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR515-2 MIR519C MIR1283-1 MIR520A MIR515-1
GH19F053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +124.2 124218 1.0 ZNF121 ZNF263 ZNF366 HLF EED CEBPB ZBTB17 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR519C MIR520A MIR515-1 MIR519E
GH19F053634 1 ENCODE 10.1 -86.1 -86056 2.0 HDGF PKNOX1 ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 ZNF207 FOS ZNF765 LENG1 MIR520A MIR526B MIR518F MIR519B MIR525 MIR518B MIR520B MIR520C
GH19F053898 0.9 Ensembl ENCODE 10.6 +177.8 177767 1.3 KLF1 PKNOX1 MAZ SP3 ZNF740 SP2 REST SP1 PATZ1 KLF9 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A MIR516A2 RNU6-1041P MIR1283-2 MIR516A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR517B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR517B Gene

Chromosome:
19
Start:
53,721,076 bp from pter
End:
53,721,142 bp from pter
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR517B Gene

Genes around MIR517B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR517B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR517B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR517B Gene

Proteins for MIR517B Gene

Post-translational modifications for MIR517B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517B Gene

Domains & Families for MIR517B Gene

Gene Families for MIR517B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR517B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR517B Gene

Function for MIR517B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR517B Gene

Localization for MIR517B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR517B Gene

Pathways & Interactions for MIR517B Gene

SuperPathways for MIR517B Gene

No Data Available

Interacting Proteins for MIR517B Gene

Gene Ontology (GO) - Biological Process for MIR517B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR517B Gene

Transcripts for MIR517B Gene

mRNA/cDNA for MIR517B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517B Gene

No ASD Table

Relevant External Links for MIR517B Gene

GeneLoc Exon Structure for
MIR517B
ECgene alternative splicing isoforms for
MIR517B

Expression for MIR517B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR517B Gene:

MIR517B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR517B Gene

Orthologs for MIR517B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-517b-1 35
  • 94 (a)
OneToOne
Species where no ortholog for MIR517B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR517B Gene

ENSEMBL:
Gene Tree for MIR517B (if available)
TreeFam:
Gene Tree for MIR517B (if available)

Paralogs for MIR517B Gene

No data available for Paralogs for MIR517B Gene

Variants for MIR517B Gene

Sequence variations from dbSNP and Humsavar for MIR517B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10415682 -- 53,720,739(+) gggcg(C/G)tgtgg upstream-variant-2KB
rs10451450 -- 53,719,245(+) ttttg(A/C)gactg upstream-variant-2KB
rs111404011 -- 53,721,561(+) CTGGA(A/G)TGCAG downstream-variant-500B, upstream-variant-2KB
rs112076618 -- 53,720,635(+) AACCC(A/G)GGAGG downstream-variant-500B, upstream-variant-2KB
rs112769118 -- 53,719,773(+) CTATA(C/G)CTGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR517B Gene

Variant ID Type Subtype PubMed ID
nsv961246 CNV duplication 23825009
nsv580108 CNV gain 21841781
nsv458781 CNV gain 19166990
esv2762049 CNV gain 21179565
esv2718837 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718812 CNV deletion 23290073

Relevant External Links for MIR517B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR517B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR517B Gene

Disorders for MIR517B Gene

Relevant External Links for MIR517B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR517B

No disorders were found for MIR517B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR517B Gene

Publications for MIR517B Gene

  1. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. (PMID: 25799546) Anton L. … Elovitz M.A. (PLoS ONE 2015) 3 64
  2. Underexpression of 4 placenta-associated microRNAs in complete hydatidiform moles. (PMID: 22672989) Na Q. … Song W. (Int. J. Gynecol. Cancer 2012) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3 64

Products for MIR517B Gene

Sources for MIR517B Gene

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