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MIR517A Gene(RNA Gene)

MicroRNA 517a

GCID:
GC19P053712
GIFtS:
15
Genes Participants
UDN Logo

Aliases for MIR517A Gene

Subcategory (RNA class) for MIR517A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR517A Gene

  • MicroRNA 517a 2 3 5
  • Hsa-Mir-517a 3
  • Mir-517a 3
  • MIRN517A 3

External Ids for MIR517A Gene

ORGUL Members for MIR517A Gene

Previous HGNC Symbols for MIR517A Gene

  • MIRN517A

Previous GeneCards Identifiers for MIR517A Gene

  • GC19P058940
  • GC19P059004
  • GC19P054215

Summaries for MIR517A Gene

Entrez Gene Summary for MIR517A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517A Gene

MIR517A (MicroRNA 517a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR517A Gene

Genomics for MIR517A Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR517A Gene

Enhancers for MIR517A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053611 1.4 ENCODE dbSUPER 10.8 -99.3 -99303 3.1 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF765 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C
GH19G053840 1.3 Ensembl ENCODE 10.5 +129.9 129861 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 GATA2 ZNF143 FOS SP3 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19G053659 1.1 ENCODE dbSUPER 11.1 -51.0 -50993 2.7 ELF3 PKNOX1 CREM SP3 SP5 REST PPARG SP1 ETV4 PBX2 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19G053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +132.8 132826 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19G053660 1 ENCODE dbSUPER 11.1 -52.8 -52767 0.2 HDAC1 CTCF ATF1 SAP30 MAX SIN3A RBBP5 RAD21 GATA3 POLR2A MIR520A RN7SL317P DPRX MIR526B MIR519B MIR525 MIR518B MIR518F MIR520B MIR520C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR517A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR517A Gene

Chromosome:
19
Start:
53,712,268 bp from pter
End:
53,712,354 bp from pter
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR517A Gene

Genes around MIR517A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR517A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR517A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR517A Gene

Proteins for MIR517A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR517A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517A Gene

Domains & Families for MIR517A Gene

Gene Families for MIR517A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR517A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR517A Gene

Function for MIR517A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR517A Gene

Localization for MIR517A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR517A Gene

Pathways & Interactions for MIR517A Gene

SuperPathways for MIR517A Gene

PathCards logo More details on SuperPathways for MIR517A
No Data Available

Interacting Proteins for MIR517A Gene

Gene Ontology (GO) - Biological Process for MIR517A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR517A Gene

Drugs & Compounds for MIR517A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR517A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR517A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517A Gene

No ASD Table

Relevant External Links for MIR517A Gene

GeneLoc Exon Structure for
MIR517A
ECgene alternative splicing isoforms for
MIR517A

Expression for MIR517A Gene

Products:

  1. Primer

NURSA nuclear receptor signaling pathways regulating expression of MIR517A Gene:

MIR517A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR517A Gene

Orthologs for MIR517A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-517a 35
  • 100 (a)
 OneToOne
Species where no ortholog for MIR517A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR517A Gene

ENSEMBL:
Gene Tree for MIR517A (if available)
TreeFam:
Gene Tree for MIR517A (if available)

Paralogs for MIR517A Gene

No data available for Paralogs for MIR517A Gene

Variants for MIR517A Gene

Sequence variations from dbSNP and Humsavar for MIR517A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000707151 -- 53,710,288(+) GGCTG(A/G)GGCAG upstream-variant-2KB
rs1001885902 -- 53,710,479(+) TTATT(G/T)TTTCT upstream-variant-2KB
rs1003421909 -- 53,711,394(+) TGAGA(A/T)TACAG downstream-variant-500B, upstream-variant-2KB
rs1003794750 -- 53,711,231(+) GTGCG(A/G)TGGCA downstream-variant-500B, upstream-variant-2KB
rs1003963849 -- 53,711,533(+) CCTCC(C/T)GGATT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR517A Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR517A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR517A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR517A Gene

Disorders for MIR517A Gene

Relevant External Links for MIR517A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR517A

No disorders were found for MIR517A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR517A Gene

Publications for MIR517A Gene

  1. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. (PMID: 25799546) Anton L. … Elovitz M.A. (PLoS ONE 2015) 3 64
  2. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation. (PMID: 26040940) Hasegawa Y. … Masuzaki H. (Reprod Sci 2015) 3 64
  3. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression. (PMID: 24846831) Jin J. … Zhang B. (Life Sci. 2014) 3 64
  4. Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells. (PMID: 25273530) Kambe S. … Takizawa T. (Biol. Reprod. 2014) 3 64
  5. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. (PMID: 23142219) Liu R.F. … Han Z.G. (Cancer Lett. 2013) 3 64

Products for MIR517A Gene

Sources for MIR517A Gene

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