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MIR517A Gene(RNA Gene)

MicroRNA 517a

GCID:
GC19P053712
GIFtS:
13
Genes Participants
UDN Logo

Aliases for MIR517A Gene

Subcategory (RNA class) for MIR517A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR517A Gene

  • MicroRNA 517a 2 3 5
  • Hsa-Mir-517a 3
  • Mir-517a 3
  • MIRN517A 3

External Ids for MIR517A Gene

ORGUL Members for MIR517A Gene

Previous HGNC Symbols for MIR517A Gene

  • MIRN517A

Previous GeneCards Identifiers for MIR517A Gene

  • GC19P058940
  • GC19P059004
  • GC19P054215

Summaries for MIR517A Gene

Entrez Gene Summary for MIR517A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517A Gene

MIR517A (MicroRNA 517a) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR517A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR517A Gene

Genomics for MIR517A Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR517A Gene

Promoters and enhancers for MIR517A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I053840 Enhancer 1.1 Ensembl ENCODE 10.5 +129.9 129861 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR519C MIR515-2 MIR515-1
GH19I053659 Enhancer 0.9 ENCODE dbSUPER 11.1 -51.0 -50993 2.7 ELF3 SOX13 FOXA2 SAP130 NR2F6 CREM GATAD2A SOX5 SP5 PPARG MIR515-2 MIR520A MIR519C MIR1283-1 MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19I053611 Enhancer 0.9 ENCODE dbSUPER 10.8 -99.3 -99303 3.1 SOX13 ESRRA USF1 FOXA2 NEUROD1 TEAD3 CTBP1 GATA3 POLR2A NR2F6 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR520B MIR518F MIR520C MIR526A1
GH19I053898 Enhancer 0.9 Ensembl ENCODE 10.6 +186.6 186574 1.3 KLF1 PKNOX1 BACH1 ZNF335 POLR2A PATZ1 PRDM10 KLF8 KLF13 SP3 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A RNU6-1041P MIR516A2 MIR519A1 RNU6-751P
GH19I053844 Enhancer 0.9 FANTOM5 Ensembl ENCODE 10.5 +132.8 132826 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR519E MIR515-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR517A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR517A Gene

Genomic Locations for MIR517A Gene
chr19:53,712,268-53,712,354
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,215,522-54,215,608
(GRCh37/hg19)

Genomic View for MIR517A Gene

Genes around MIR517A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR517A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR517A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR517A Gene

Proteins for MIR517A Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR517A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517A Gene

Domains & Families for MIR517A Gene

Gene Families for MIR517A Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR517A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR517A Gene

Function for MIR517A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR517A Gene

Localization for MIR517A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR517A Gene

Pathways & Interactions for MIR517A Gene

SuperPathways for MIR517A Gene

PathCards logo More details on SuperPathways for MIR517A
No Data Available

Interacting Proteins for MIR517A Gene

Gene Ontology (GO) - Biological Process for MIR517A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR517A Gene

Drugs & Compounds for MIR517A Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR517A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR517A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517A Gene

No ASD Table

Relevant External Links for MIR517A Gene

GeneLoc Exon Structure for
MIR517A
ECgene alternative splicing isoforms for
MIR517A

Expression for MIR517A Gene

Products:

  1. Primer

NURSA nuclear receptor signaling pathways regulating expression of MIR517A Gene:

MIR517A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR517A Gene

Orthologs for MIR517A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-517a 34
  • 100 (a)
 OneToOne
Species where no ortholog for MIR517A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR517A Gene

ENSEMBL:
Gene Tree for MIR517A (if available)
TreeFam:
Gene Tree for MIR517A (if available)

Paralogs for MIR517A Gene

No data available for Paralogs for MIR517A Gene

Variants for MIR517A Gene

Sequence variations from dbSNP and Humsavar for MIR517A Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000707151 -- 53,710,288(+) A/G upstream_transcript_variant
rs1001885902 -- 53,710,479(+) T/G upstream_transcript_variant
rs1003421909 -- 53,711,394(+) T/A upstream_transcript_variant
rs1003794750 -- 53,711,231(+) G/A upstream_transcript_variant
rs1003963849 -- 53,711,533(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR517A Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR517A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR517A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR517A Gene

Disorders for MIR517A Gene

Additional Disease Information for MIR517A

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR517A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR517A Gene

Publications for MIR517A Gene

  1. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation. (PMID: 26040940) Hasegawa Y … Masuzaki H (Reproductive sciences (Thousand Oaks, Calif.) 2015) 3 58
  2. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. (PMID: 25799546) Anton L … Elovitz MA (PloS one 2015) 3 58
  3. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression. (PMID: 24846831) Jin J … Zhang B (Life sciences 2014) 3 58
  4. Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells. (PMID: 25273530) Kambe S … Takizawa T (Biology of reproduction 2014) 3 58
  5. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. (PMID: 23142219) Liu RF … Han ZG (Cancer letters 2013) 3 58

Products for MIR517A Gene

Sources for MIR517A Gene

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