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Aliases for MIR516B1 Gene

Subcategory (RNA class) for MIR516B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR516B1 Gene

  • MicroRNA 516b-1 2 3
  • MicroRNA 516-4 2 3
  • Hsa-Mir-516b-1 3
  • Hsa-Mir-516-4 3
  • MIRN516B-1 3
  • Mir-516b-1 3
  • MIRN516-4 3
  • MIRN516B1 3

External Ids for MIR516B1 Gene

ORGUL Members for MIR516B1 Gene

Previous HGNC Symbols for MIR516B1 Gene

  • MIRN516-4
  • MIRN516B1

Previous GeneCards Identifiers for MIR516B1 Gene

  • GC19P058972
  • GC19P059016
  • GC19P054240

Summaries for MIR516B1 Gene

Entrez Gene Summary for MIR516B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR516B1 Gene

MIR516B1 (MicroRNA 516b-1) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR516B1 Gene

Genomics for MIR516B1 Gene

Genomic Location for MIR516B1 Gene

Chromosome:
19
Start:
53,736,840 bp from pter
End:
53,736,949 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR516B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR516B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR516B1 Gene

No data available for Regulatory Elements for MIR516B1 Gene

Proteins for MIR516B1 Gene

Post-translational modifications for MIR516B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR516B1 Gene

Domains & Families for MIR516B1 Gene

Gene Families for MIR516B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR516B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR516B1 Gene

Function for MIR516B1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR516B1 Gene

Localization for MIR516B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR516B1 Gene

Pathways & Interactions for MIR516B1 Gene

SuperPathways for MIR516B1 Gene

No Data Available

Interacting Proteins for MIR516B1 Gene

Gene Ontology (GO) - Biological Process for MIR516B1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR516B1 Gene

Drugs & Compounds for MIR516B1 Gene

No Compound Related Data Available

Transcripts for MIR516B1 Gene

mRNA/cDNA for MIR516B1 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR516B1 Gene

No ASD Table

Relevant External Links for MIR516B1 Gene

GeneLoc Exon Structure for
MIR516B1
ECgene alternative splicing isoforms for
MIR516B1

Expression for MIR516B1 Gene

mRNA expression in normal human tissues for MIR516B1 Gene

genes like me logo Genes that share expression patterns with MIR516B1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR516B1 Gene

Orthologs for MIR516B1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR516B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-516b-1 36
  • 99 (a)
OneToOne
Species with no ortholog for MIR516B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR516B1 Gene

ENSEMBL:
Gene Tree for MIR516B1 (if available)
TreeFam:
Gene Tree for MIR516B1 (if available)

Paralogs for MIR516B1 Gene

No data available for Paralogs for MIR516B1 Gene

Variants for MIR516B1 Gene

Sequence variations from dbSNP and Humsavar for MIR516B1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4802000 -- 53,735,795(+) GAGAC(A/G)GGGGT upstream-variant-2KB
rs4803169 -- 53,735,621(+) AAATT(A/T)TTCTG upstream-variant-2KB
rs4803170 -- 53,735,779(+) CAGGA(A/G)ATAAA upstream-variant-2KB
rs7259867 -- 53,736,335(+) gtgct(A/G/T)gaatt upstream-variant-2KB
rs9917083 -- 53,735,493(+) gctac(C/T)ttttg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR516B1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073
esv2718837 CNV Deletion 23290073
esv2448351 CNV Deletion 19546169
esv2718838 CNV Deletion 23290073

Relevant External Links for MIR516B1 Gene

HapMap Linkage Disequilibrium report
MIR516B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR516B1 Gene

Disorders for MIR516B1 Gene

Relevant External Links for MIR516B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR516B1
genes like me logo Genes that share disorders with MIR516B1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR516B1 Gene

Publications for MIR516B1 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 67
  2. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 67
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 67
  4. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 67

Products for MIR516B1 Gene

Sources for MIR516B1 Gene

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