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MIR516A2 Gene(RNA Gene)

MicroRNA 516a-2

GCID:
GC19P053761
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR516A2 Gene

Subcategory (RNA class) for MIR516A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR516A2 Gene

  • MicroRNA 516a-2 2 3 5
  • MicroRNA 516-2 2 3
  • Hsa-Mir-516a-2 3
  • Hsa-Mir-516-2 3
  • MIRN516A-2 3
  • Mir-516a-2 3
  • MIRN516-2 3
  • MIRN516A2 3

External Ids for MIR516A2 Gene

ORGUL Members for MIR516A2 Gene

Previous HGNC Symbols for MIR516A2 Gene

  • MIRN516-2
  • MIRN516A2

Previous GeneCards Identifiers for MIR516A2 Gene

  • GC19P058988
  • GC19P059027
  • GC19P054265
  • GC19P054267
  • GC19P054315
  • GC19P054340
  • GC19P054425
  • GC19P054504

Summaries for MIR516A2 Gene

Entrez Gene Summary for MIR516A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR516A2 Gene

MIR516A2 (MicroRNA 516a-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR516A2 Gene

Genomics for MIR516A2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR516A2 Gene

Enhancers for MIR516A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053611 1.4 ENCODE dbSUPER 10.8 -148.2 -148168 3.1 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF765 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C
GH19G053840 1.3 Ensembl ENCODE 10.5 +81.0 80996 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 GATA2 ZNF143 FOS SP3 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19G053659 1.1 ENCODE dbSUPER 11 -99.9 -99858 2.7 ELF3 PKNOX1 CREM SP3 SP5 REST PPARG SP1 ETV4 PBX2 MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19G053844 1.1 FANTOM5 Ensembl ENCODE 10.5 +84.0 83961 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19G053660 1 ENCODE dbSUPER 11 -101.6 -101632 0.2 HDAC1 CTCF ATF1 SAP30 MAX SIN3A RBBP5 RAD21 GATA3 POLR2A MIR520A RN7SL317P DPRX MIR526B MIR519B MIR525 MIR518B MIR518F MIR520B MIR520C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR516A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR516A2 Gene

Chromosome:
19
Start:
53,761,133 bp from pter
End:
53,761,222 bp from pter
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR516A2 Gene

Genes around MIR516A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR516A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR516A2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR516A2 Gene

Proteins for MIR516A2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR516A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR516A2 Gene

Domains & Families for MIR516A2 Gene

Gene Families for MIR516A2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR516A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR516A2 Gene

Function for MIR516A2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR516A2 Gene

Localization for MIR516A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR516A2 Gene

Pathways & Interactions for MIR516A2 Gene

SuperPathways for MIR516A2 Gene

PathCards logo More details on SuperPathways for MIR516A2
No Data Available

Interacting Proteins for MIR516A2 Gene

Gene Ontology (GO) - Biological Process for MIR516A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR516A2 Gene

Drugs & Compounds for MIR516A2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR516A2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MIR516A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR516A2 Gene

No ASD Table

Relevant External Links for MIR516A2 Gene

GeneLoc Exon Structure for
MIR516A2
ECgene alternative splicing isoforms for
MIR516A2

Expression for MIR516A2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR516A2 Gene

mRNA expression in normal human tissues for MIR516A2 Gene
mRNA expression by GTEx for MIR516A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR516A2 Gene:

MIR516A2
genes like me logo Genes that share expression patterns with MIR516A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR516A2 Gene

Orthologs for MIR516A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR516A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-516a-2 35
  • 100 (a)
 OneToOne
Species where no ortholog for MIR516A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR516A2 Gene

ENSEMBL:
Gene Tree for MIR516A2 (if available)
TreeFam:
Gene Tree for MIR516A2 (if available)

Paralogs for MIR516A2 Gene

No data available for Paralogs for MIR516A2 Gene

Variants for MIR516A2 Gene

Sequence variations from dbSNP and Humsavar for MIR516A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000962107 -- 53,760,731(+) AGAGA(A/G)TGTTT upstream-variant-2KB
rs1001753652 -- 53,759,632(+) AGCTA(C/T)TCGGG upstream-variant-2KB
rs1001753799 -- 53,759,864(+) AAAAC(C/T)TCATC upstream-variant-2KB
rs1002508335 -- 53,760,783(+) CTCCC(A/T)TTGGG upstream-variant-2KB
rs1004814821 -- 53,760,447(+) TGGTG(C/T)GTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR516A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Relevant External Links for MIR516A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR516A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR516A2 Gene

Disorders for MIR516A2 Gene

Relevant External Links for MIR516A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR516A2

No disorders were found for MIR516A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR516A2 Gene

Publications for MIR516A2 Gene

  1. Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms. (PMID: 23746831) Cheuk B.L. … Cheng S.W. (J. Vasc. Surg. 2014) 3 64
  2. High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus. (PMID: 24687380) Zhu J. … Song G. (Clin. Rheumatol. 2014) 3 64
  3. Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients. (PMID: 24931722) Gattolliat C.H. … Douc-Rasy S. (Cancer Med 2014) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR516A2 Gene

Sources for MIR516A2 Gene

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