Aliases for MIR516A2 Gene
Subcategory (RNA class) for MIR516A2 Gene
Quality Score for this RNA gene is
Aliases for MIR516A2 Gene
External Ids for MIR516A2 Gene
- HGNC: 32131
- Entrez Gene: 574499
- Ensembl: ENSG00000207620
- miRBase: hsa-mir-516a-2
Previous HGNC Symbols for MIR516A2 Gene
- MIRN516-2
- MIRN516A2
Previous GeneCards Identifiers for MIR516A2 Gene
- GC19P058988
- GC19P059027
- GC19P054265
- GC19P054267
- GC19P054315
- GC19P054340
- GC19P054425
- GC19P054504
Summaries for MIR516A2 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR516A2 Gene
MIR516A2 (MicroRNA 516a-2) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR516A2 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR516A2 Gene
Genomics for MIR516A2 Gene
GeneHancer (GH) Regulatory Elements for MIR516A2 Gene
Regulatory Element Products
Genomic Locations for MIR516A2 Gene
- chr19:53,761,133-53,761,222
- (GRCh38/hg38)
- Size:
- 90 bases
- Orientation:
- Plus strand
- chr19:54,264,387-54,264,476
- (GRCh37/hg19)
Genomic View for MIR516A2 Gene
- Cytogenetic band:
-
- 19q13.42 by Ensembl
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC


RefSeq DNA sequence for MIR516A2 Gene
Proteins for MIR516A2 Gene
Post-translational modifications for MIR516A2 Gene
Antibody Products
- Search GeneTex for Antibodies for MIR516A2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR516A2
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- Search GeneTex for Proteins for MIR516A2
No data available for DME Specific Peptides for MIR516A2 Gene
Domains & Families for MIR516A2 Gene
Gene Families for MIR516A2 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR516A2 Gene
Function for MIR516A2 Gene
Animal Model Products
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-
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CRISPR Products
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR516A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR516A2 Gene
Localization for MIR516A2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR516A2 Gene
Transcripts for MIR516A2 Gene
mRNA/cDNA for MIR516A2 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR516A2
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
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Inhibitory RNA Products
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Clone Products
- GenScript: Custom all cDNA clones Services for MIR516A2
- VectorBuilder custom plasmid, inducible vectors for MIR516A2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR516A2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR516A2 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR516A2 Gene:
MIR516A2Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR516A2 Gene
Orthologs for MIR516A2 Gene
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-516a-2 34 |
|
OneToOne |
- Species where no ortholog for MIR516A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR516A2 Gene
No data available for Paralogs for MIR516A2 Gene
Variants for MIR516A2 Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000962107 | -- | 53,760,731(+) | A/G | upstream_transcript_variant | |
rs1001753652 | -- | 53,759,632(+) | C/T | upstream_transcript_variant | |
rs1001753799 | -- | 53,759,864(+) | C/T | upstream_transcript_variant | |
rs1002508335 | -- | 53,760,783(+) | A/T | upstream_transcript_variant | |
rs1004814821 | -- | 53,760,447(+) | C/T | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2718812 | CNV | deletion | 23290073 |
nsv1058969 | CNV | gain | 25217958 |
nsv458781 | CNV | gain | 19166990 |
nsv580108 | CNV | gain | 21841781 |
nsv961246 | CNV | duplication | 23825009 |
Additional Variant Information for MIR516A2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR516A2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR516A2 Gene
Disorders for MIR516A2 Gene
Additional Disease Information for MIR516A2
No disorders were found for MIR516A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR516A2 Gene
Publications for MIR516A2 Gene
- Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms. (PMID: 23746831) Cheuk BL … Cheng SW (Journal of vascular surgery 2014) 3 58
- High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus. (PMID: 24687380) Zhu J … Song G (Clinical rheumatology 2014) 3 58
- Expression of two parental imprinted miRNAs improves the risk stratification of neuroblastoma patients. (PMID: 24931722) Gattolliat CH … Douc-Rasy S (Cancer medicine 2014) 3 58
- miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
Products for MIR516A2 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR516A2
- VectorBuilder custom plasmid, inducible vectors for MIR516A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR516A2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR516A2
- Search GeneTex for Proteins for MIR516A2
Sources for MIR516A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew