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Aliases for MIR516A2 Gene

Subcategory (RNA class) for MIR516A2 Gene


Quality Score for this RNA gene is


Aliases for MIR516A2 Gene

  • MicroRNA 516a-2 2 3
  • MicroRNA 516-2 2 3
  • Hsa-Mir-516a-2 3
  • Hsa-Mir-516-2 3
  • MIRN516A-2 3
  • MIRN516-2 3
  • MIRN516A2 3

External Ids for MIR516A2 Gene

ORGUL Members for MIR516A2 Gene

Previous HGNC Symbols for MIR516A2 Gene

  • MIRN516-2
  • MIRN516A2

Previous GeneCards Identifiers for MIR516A2 Gene

  • GC19P058988
  • GC19P059027
  • GC19P054265
  • GC19P054267
  • GC19P054315
  • GC19P054340
  • GC19P054425
  • GC19P054504

Summaries for MIR516A2 Gene

Entrez Gene Summary for MIR516A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR516A2 Gene

MIR516A2 (MicroRNA 516a-2) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR516A2 Gene

Genomics for MIR516A2 Gene

Genomic Location for MIR516A2 Gene

53,761,133 bp from pter
53,761,222 bp from pter
90 bases
Plus strand

Genomic View for MIR516A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR516A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR516A2 Gene

No data available for Regulatory Elements for MIR516A2 Gene

Proteins for MIR516A2 Gene

Post-translational modifications for MIR516A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR516A2 Gene

Domains for MIR516A2 Gene

Gene Families for MIR516A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR516A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR516A2 Gene

Function for MIR516A2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR516A2 Gene

Localization for MIR516A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR516A2 Gene

Pathways for MIR516A2 Gene

SuperPathways for MIR516A2 Gene

No Data Available

Interacting Proteins for MIR516A2 Gene

Gene Ontology (GO) - Biological Process for MIR516A2 Gene


No data available for Pathways by source for MIR516A2 Gene

Transcripts for MIR516A2 Gene

mRNA/cDNA for MIR516A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR516A2 Gene

No ASD Table

Relevant External Links for MIR516A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR516A2 Gene

mRNA expression in normal human tissues for MIR516A2 Gene

genes like me logo Genes that share expressions with MIR516A2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR516A2 Gene

Orthologs for MIR516A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR516A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-516a-2 36
  • 100 (a)
Species with no ortholog for MIR516A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR516A2 Gene

Gene Tree for MIR516A2 (if available)
Gene Tree for MIR516A2 (if available)

Paralogs for MIR516A2 Gene

No data available for Paralogs for MIR516A2 Gene

Variants for MIR516A2 Gene

Sequence variations from dbSNP and Humsavar for MIR516A2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs575369575 -- 53,760,069(+) ATTAA(A/G)TAGAT upstream-variant-2KB
rs572765371 -- 53,760,131(+) TGCAG(C/G)GGCCA upstream-variant-2KB
rs569697575 -- 53,759,269(+) GGACT(A/C)CATGT upstream-variant-2KB
rs567556575 -- 53,759,811(+) GAGAC(C/G)GGAGG upstream-variant-2KB
rs566143574 -- 53,759,228(+) AGATC(C/T)TCCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR516A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990

Relevant External Links for MIR516A2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR516A2 Gene

Disorders for MIR516A2 Gene

No disorders were found for MIR516A2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR516A2 Gene

Publications for MIR516A2 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Identification and characterization of microRNAs in vascular smooth muscle cells from patients with abdominal aortic aneurysms. (PMID: 23746831) Cheuk B.L. … Cheng S.W. (J. Vasc. Surg. 2014) 3
  5. High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus. (PMID: 24687380) Zhu J. … Song G. (Clin. Rheumatol. 2014) 3

Products for MIR516A2 Gene

Sources for MIR516A2 Gene

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