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Aliases for MIR515-2 Gene

Subcategory (RNA class) for MIR515-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR515-2 Gene

  • MicroRNA 515-2 2 3
  • Hsa-Mir-515-2 3
  • MIRN515-2 3

External Ids for MIR515-2 Gene

ORGUL Members for MIR515-2 Gene

Previous Symbols for MIR515-2 Gene

  • MIRN515-2

Summaries for MIR515-2 Gene

Entrez Gene Summary for MIR515-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR515-2 Gene

MIR515-2 (MicroRNA 515-2) is a RNA Gene, and belongs to miRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR515-2 Gene

Genomics for MIR515-2 Gene

Genomic Location for MIR515-2 Gene

Start:
53,685,009 bp from pter
End:
53,685,091 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR515-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR515-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR515-2 Gene

No data available for Regulatory Elements for MIR515-2 Gene

Proteins for MIR515-2 Gene

Post-translational modifications for MIR515-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR515-2 Gene

Domains for MIR515-2 Gene

Gene Families for MIR515-2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR515-2: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR515-2 Gene

Function for MIR515-2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR515-2 Gene

Localization for MIR515-2 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR515-2 Gene

Pathways for MIR515-2 Gene

SuperPathways for MIR515-2 Gene

No Data Available

Interacting Proteins for MIR515-2 Gene

Gene Ontology (GO) - Biological Process for MIR515-2 Gene

None

No data available for Pathways by source for MIR515-2 Gene

Transcripts for MIR515-2 Gene

mRNA/cDNA for MIR515-2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR515-2 Gene

No ASD Table

Relevant External Links for MIR515-2 Gene

GeneLoc Exon Structure for
MIR515-2
ECgene alternative splicing isoforms for
MIR515-2

Expression for MIR515-2 Gene

mRNA expression in normal human tissues for MIR515-2 Gene

genes like me logo Genes that share expressions with MIR515-2: view

Orthologs for MIR515-2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR515-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-515-1 37
  • 100 (a)
OneToMany
Species with no ortholog for MIR515-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR515-2 Gene

ENSEMBL:
Gene Tree for MIR515-2 (if available)
TreeFam:
Gene Tree for MIR515-2 (if available)

Paralogs for MIR515-2 Gene

No data available for Paralogs for MIR515-2 Gene

Variants for MIR515-2 Gene

Sequence variations from dbSNP and Humsavar for MIR515-2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1643 -- 53,684,418(-) GATTA(C/T)AGGCA upstream-variant-2KB
rs1968438 -- 53,684,172(-) GGTCT(C/T)AAACT upstream-variant-2KB
rs7246572 -- 53,683,648(+) GGTGT(A/C)GGCAT upstream-variant-2KB
rs7258109 -- 53,683,220(+) GGAGA(A/G)GCAGG upstream-variant-2KB
rs7258164 -- 53,683,025(+) TGGGC(A/G)GAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR515-2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv912385 CNV Gain 21882294
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990
esv2718833 CNV Deletion 23290073

Relevant External Links for MIR515-2 Gene

HapMap Linkage Disequilibrium report
MIR515-2

Disorders for MIR515-2 Gene

No disorders were found for MIR515-2 Gene.

No data available for UniProtKB/Swiss-Prot for MIR515-2 Gene

Publications for MIR515-2 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers. (PMID: 23549953) Gilam A. … Shomron N. (Breast Cancer Res. Treat. 2013) 3

Products for MIR515-2 Gene

Sources for MIR515-2 Gene

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