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Aliases for MIR514A3 Gene

Subcategory (RNA class) for MIR514A3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR514A3 Gene

  • MicroRNA 514a-3 2 3 5
  • MicroRNA 514-3 2 3
  • Hsa-Mir-514a-3 3
  • Hsa-Mir-514-3 3
  • MIRN514-3 3
  • MIR514-3 3

External Ids for MIR514A3 Gene

Previous HGNC Symbols for MIR514A3 Gene

  • MIRN514-3
  • MIR514-3

Previous GeneCards Identifiers for MIR514A3 Gene

  • GC0XM146364
  • GC0XM146369
  • GC0XM146375

Summaries for MIR514A3 Gene

Entrez Gene Summary for MIR514A3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR514A3 Gene

MIR514A3 (MicroRNA 514a-3) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR514A3 Gene

Genomics for MIR514A3 Gene

Genomic Location for MIR514A3 Gene

Chromosome:
X
Start:
147,284,641 bp from pter
End:
147,284,728 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR514A3 Gene

Genes around MIR514A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR514A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR514A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR514A3 Gene

No data available for Regulatory Elements for MIR514A3 Gene

Proteins for MIR514A3 Gene

Post-translational modifications for MIR514A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR514A3 Gene

Domains & Families for MIR514A3 Gene

Gene Families for MIR514A3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR514A3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR514A3 Gene

Function for MIR514A3 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR514A3 Gene

Localization for MIR514A3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR514A3 Gene

Pathways & Interactions for MIR514A3 Gene

SuperPathways for MIR514A3 Gene

No Data Available

Interacting Proteins for MIR514A3 Gene

Gene Ontology (GO) - Biological Process for MIR514A3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR514A3 Gene

Drugs & Compounds for MIR514A3 Gene

No Compound Related Data Available

Transcripts for MIR514A3 Gene

mRNA/cDNA for MIR514A3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR514A3 Gene

No ASD Table

Relevant External Links for MIR514A3 Gene

GeneLoc Exon Structure for
MIR514A3
ECgene alternative splicing isoforms for
MIR514A3

Expression for MIR514A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR514A3 Gene:

MIR514A3
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR514A3 Gene

Orthologs for MIR514A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR514A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-514-2 35 35
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia cfa-mir-514 35
  • 86 (a)
OneToMany
Species where no ortholog for MIR514A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR514A3 Gene

ENSEMBL:
Gene Tree for MIR514A3 (if available)
TreeFam:
Gene Tree for MIR514A3 (if available)

Paralogs for MIR514A3 Gene

No data available for Paralogs for MIR514A3 Gene

Variants for MIR514A3 Gene

Sequence variations from dbSNP and Humsavar for MIR514A3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111530884 -- 147,285,697(+) GGAAA(G/T)TCAAG intron-variant, upstream-variant-2KB
rs112288148 -- 147,285,653(+) TGTTA(A/C)TTACA intron-variant, upstream-variant-2KB
rs112399620 -- 147,286,345(+) GGATA(A/G)GAATT intron-variant, upstream-variant-2KB
rs12008883 -- 147,286,380(+) TGTGC(A/T)CAGCC nc-transcript-variant, upstream-variant-2KB
rs12852254 -- 147,285,926(+) TAGCT(G/T)CAGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR514A3 Gene

Variant ID Type Subtype PubMed ID
esv22917 CNV gain+loss 19812545
esv2758898 CNV gain 17122850
esv3356512 CNV duplication 20981092
esv35128 CNV gain 17911159
esv3574899 CNV loss 25503493
esv3577461 CNV gain 25503493
esv999927 CNV loss 20482838
nsv1077599 CNV duplication 25765185
nsv1125132 CNV duplication 24896259
nsv1151566 CNV duplication 26484159
nsv216 CNV insertion 15895083
nsv508808 CNV insertion 20534489
nsv521982 CNV gain 19592680
nsv522113 CNV gain 19592680
nsv7138 CNV insertion 18451855
nsv953700 CNV duplication 24416366
nsv9988 CNV gain+loss 18304495

Relevant External Links for MIR514A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR514A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR514A3 Gene

Disorders for MIR514A3 Gene

Relevant External Links for MIR514A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR514A3

No disorders were found for MIR514A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR514A3 Gene

Publications for MIR514A3 Gene

  1. miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma. (PMID: 25980496) Stark M.S. … Hayward N.K. (Oncotarget 2015) 3 64
  2. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  4. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3 64

Products for MIR514A3 Gene

Sources for MIR514A3 Gene

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