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Aliases for MIR512-1 Gene

Subcategory (RNA class) for MIR512-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR512-1 Gene

  • MicroRNA 512-1 2 3 5
  • Hsa-Mir-512-1 3
  • Mir-512-1 3
  • MIRN512-1 3

External Ids for MIR512-1 Gene

ORGUL Members for MIR512-1 Gene

Previous HGNC Symbols for MIR512-1 Gene

  • MIRN512-1

Previous GeneCards Identifiers for MIR512-1 Gene

  • GC19P058862
  • GC19P054169
  • GC19P053669
  • GC19P053693
  • GC19P053724

Summaries for MIR512-1 Gene

Entrez Gene Summary for MIR512-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR512-1 Gene

MIR512-1 (MicroRNA 512-1) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR512-1 Gene

Genomics for MIR512-1 Gene

Regulatory Elements for MIR512-1 Gene

Enhancers for MIR512-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053668 0.7 ENCODE dbSUPER 0.7 +2.3 2263 0.3 CTCF AGO1 MIR512-2 MIR512-1
GH19G053667 0.5 ENCODE dbSUPER 0.7 +0.8 773 0.9 MIR512-1 MIR512-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR512-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR512-1 Gene

Chromosome:
19
Start:
53,666,679 bp from pter
End:
53,666,762 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR512-1 Gene

Genes around MIR512-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR512-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR512-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR512-1 Gene

Proteins for MIR512-1 Gene

Post-translational modifications for MIR512-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR512-1 Gene

Domains & Families for MIR512-1 Gene

Gene Families for MIR512-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR512-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR512-1 Gene

Function for MIR512-1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR512-1 Gene

Localization for MIR512-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR512-1 Gene

Pathways & Interactions for MIR512-1 Gene

SuperPathways for MIR512-1 Gene

No Data Available

Interacting Proteins for MIR512-1 Gene

Gene Ontology (GO) - Biological Process for MIR512-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR512-1 Gene

Drugs & Compounds for MIR512-1 Gene

No Compound Related Data Available

Transcripts for MIR512-1 Gene

mRNA/cDNA for MIR512-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR512-1 Gene

No ASD Table

Relevant External Links for MIR512-1 Gene

GeneLoc Exon Structure for
MIR512-1
ECgene alternative splicing isoforms for
MIR512-1

Expression for MIR512-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR512-1 Gene

genes like me logo Genes that share expression patterns with MIR512-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR512-1 Gene

Orthologs for MIR512-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR512-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 22 (a)
OneToMany
Species where no ortholog for MIR512-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR512-1 Gene

ENSEMBL:
Gene Tree for MIR512-1 (if available)
TreeFam:
Gene Tree for MIR512-1 (if available)

Paralogs for MIR512-1 Gene

No data available for Paralogs for MIR512-1 Gene

Variants for MIR512-1 Gene

Sequence variations from dbSNP and Humsavar for MIR512-1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001527251 -- 53,665,700(+) CATCA(A/G)CACCT intron-variant, upstream-variant-2KB
rs1001673045 -- 53,667,108(+) CTCCC(A/G)AAGTG intron-variant, downstream-variant-500B
rs1002569618 -- 53,666,831(+) AAAAG(C/T)TAAAC intron-variant, downstream-variant-500B
rs1005791617 -- 53,665,448(+) ATTCC(C/T)GGACC intron-variant, upstream-variant-2KB
rs1006596468 -- 53,665,161(+) TCTTT(G/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR512-1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
esv5886 CNV loss 19470904
nsv1055718 CNV gain 25217958
nsv580107 CNV gain 21841781

Relevant External Links for MIR512-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR512-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR512-1 Gene

Disorders for MIR512-1 Gene

Relevant External Links for MIR512-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR512-1

No disorders were found for MIR512-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR512-1 Gene

Publications for MIR512-1 Gene

  1. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. (PMID: 26258756) Mezache L. … Nuovo G.J. (Appl. Immunohistochem. Mol. Morphol. 2015) 3 64
  2. miR-512-5p suppresses tumor growth by targeting hTERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo. (PMID: 26258591) Li J. … Tao Z.Z. (PLoS ONE 2015) 3 64
  3. Placenta-specific miRNA (miR-512-3p) targets PPP3R1 encoding the calcineurin B regulatory subunit in BeWo cells. (PMID: 24246042) Kurashina R. … Takizawa T. (J. Obstet. Gynaecol. Res. 2014) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. The two stem cell microRNA gene clusters C19MC and miR-371-3 are activated by specific chromosomal rearrangements in a subgroup of thyroid adenomas. (PMID: 20209130) Rippe V. … Bullerdiek J. (PLoS ONE 2010) 3 64

Products for MIR512-1 Gene

Sources for MIR512-1 Gene

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