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Aliases for MIR5090 Gene

Subcategory (RNA class) for MIR5090 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5090 Gene

  • MicroRNA 5090 2 3
  • LRWD1 4 5
  • Leucine Rich Repeats And WD Repeat Domain Containing 1 5
  • Origin Recognition Complex-Associated Protein 4
  • ORC-Associated Protein 4
  • Centromere Protein 33 4
  • Hsa-Mir-5090 3
  • Mir-5090 3
  • CENP-33 4
  • ORCA 4

External Ids for MIR5090 Gene

Previous GeneCards Identifiers for MIR5090 Gene

  • GC07U903236
  • GC07P102110
  • GC07P102122

Summaries for MIR5090 Gene

Entrez Gene Summary for MIR5090 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5090 Gene

MIR5090 (MicroRNA 5090) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR5090 Gene

  • Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5090 Gene

Genomics for MIR5090 Gene

Regulatory Elements for MIR5090 Gene

Enhancers for MIR5090 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F102419 0.6 Ensembl ENCODE 12.4 -44.3 -44279 2.8 HDGF PKNOX1 ARNT CREB3L1 ELK1 GATA2 ZNF143 JUNB NCOA1 TBX21 ORAI2 ALKBH4 PRKRIP1 LRWD1 MIR4467 MIR5090 ENSG00000213385 CRYZP1 LOC105375433 MIR548O
GH07F102414 1.3 FANTOM5 Ensembl ENCODE 12.4 -48.0 -47956 4.4 HDGF MAZ MXI1 MTA2 MAFG MAX JUNB TBX21 ZNF217 ZNF316 ORAI2 ALKBH4 LRWD1 MIR4467 MIR5090 POLR2J PRKRIP1 LOC105375433 MIR548O
GH07F102412 0.5 ENCODE 12.4 -52.2 -52221 0.2 CTCF SMC3 ZBTB33 REST RAD21 LRWD1 MIR4467 MIR5090 ALKBH4 MIR548O LOC105375433
GH07F102393 0.8 ENCODE 12.3 -71.0 -71028 1.6 PKNOX1 JUN MAX ZBTB40 RFX5 GATA3 POLR2A RCOR1 FOS TCF7L2 ORAI2 SH2B2 LRWD1 MIR4467 MIR5090 ALKBH4 ENSG00000239486 MIR548O
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR5090 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5090 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000312020 -229 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF207 ZNF143 KLF13 SP3

Genomic Location for MIR5090 Gene

Chromosome:
7
Start:
102,464,929 bp from pter
End:
102,473,168 bp from pter
Size:
8,240 bases
Orientation:
Plus strand

Genomic View for MIR5090 Gene

Genes around MIR5090 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5090 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5090 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5090 Gene

Proteins for MIR5090 Gene

  • Protein details for MIR5090 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFC0-LRWD1_HUMAN
    Recommended name:
    Leucine-rich repeat and WD repeat-containing protein 1
    Protein Accession:
    Q9UFC0
    Secondary Accessions:
    • A8K4K2
    • B2R9G2
    • Q8N0T9
    • Q8WV43
    • Q96GJ2

    Protein attributes for MIR5090 Gene

    Size:
    647 amino acids
    Molecular mass:
    70861 Da
    Quaternary structure:
    • Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.
    • Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.
    • Integral component of the ORC complex. Directly interacts with CDT1, GMNN and ORC2. Interacts with ORC2 only when non-ubiquitinated; this interaction prevents LRWD1 ubiquitination and degradation. Some of these interactions are regulated in a cell-cycle dependent manner. Interaction with ORC1 occurs predominantly during G1. Association with phosphorylated ORC1 during mitosis is not efficient. Interaction with CDT1 occurs during G1 phase, as well as during mitosis with phosphorylated CDT1. Interaction with GMNN occurs from G1/S to mitosis. Interaction with ORC2 is observed throughout the cell cycle. The stoichiometry of the ORCA/ORC/CDT1/GMNN complex is 1:1:1:2. Interacts with CUL4A and DDB1; this interaction may lead to ubiquitination.

neXtProt entry for MIR5090 Gene

Post-translational modifications for MIR5090 Gene

  • Ubiquitinated; undergoes Lys-48-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR5090 Gene

Domains & Families for MIR5090 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UFC0

UniProtKB/Swiss-Prot:

LRWD1_HUMAN :
  • The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3.
  • Belongs to the LRWD1 family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The entire WD repeat region is required for the interaction with ORC, CDT1 and GMNN, as well as for association with chromatin and for binding to histone H3 and H4 trimethylation marks H3K9me3 and H4K20me3.
Family:
  • Belongs to the LRWD1 family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with MIR5090: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5090 Gene

Function for MIR5090 Gene

Molecular function for MIR5090 Gene

UniProtKB/Swiss-Prot Function:
Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Gene Ontology (GO) - Molecular Function for MIR5090 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA --
GO:0005515 protein binding IPI --
GO:0008327 methyl-CpG binding IDA --
GO:0035064 methylated histone binding IDA --
genes like me logo Genes that share ontologies with MIR5090: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5090 Gene

Localization for MIR5090 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5090 Gene

Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3.

Gene Ontology (GO) - Cellular Components for MIR5090 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus IEA --
GO:0005664 nuclear origin of replication recognition complex IDA --
genes like me logo Genes that share ontologies with MIR5090: view

No data available for Subcellular locations from COMPARTMENTS for MIR5090 Gene

Pathways & Interactions for MIR5090 Gene

SuperPathways for MIR5090 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5090 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006270 DNA replication initiation TAS --
GO:0006325 chromatin organization IMP --
GO:0016569 covalent chromatin modification IEA --
GO:0071169 establishment of protein localization to chromatin IDA --
genes like me logo Genes that share ontologies with MIR5090: view

No data available for Pathways by source and SIGNOR curated interactions for MIR5090 Gene

Transcripts for MIR5090 Gene

mRNA/cDNA for MIR5090 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5090 Gene

No ASD Table

Relevant External Links for MIR5090 Gene

GeneLoc Exon Structure for
MIR5090
ECgene alternative splicing isoforms for
MIR5090

Expression for MIR5090 Gene

mRNA expression in normal human tissues for MIR5090 Gene

mRNA differential expression in normal tissues according to GTEx for MIR5090 Gene

This gene is overexpressed in Testis (x17.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR5090 Gene:

MIR5090

mRNA Expression by UniProt/SwissProt for MIR5090 Gene:

Q9UFC0-LRWD1_HUMAN
Tissue specificity: Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS).
genes like me logo Genes that share expression patterns with MIR5090: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR5090 Gene

Orthologs for MIR5090 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR5090 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRWD1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRWD1 35
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DKFZP434K1815 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrwd1 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRWD1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRWD1 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii lrwd1 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for MIR5090 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR5090 Gene

ENSEMBL:
Gene Tree for MIR5090 (if available)
TreeFam:
Gene Tree for MIR5090 (if available)

Paralogs for MIR5090 Gene

No data available for Paralogs for MIR5090 Gene

Variants for MIR5090 Gene

Sequence variations from dbSNP and Humsavar for MIR5090 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10953367 -- 102,465,469(+) CCCCC(C/G)AGTCC intron-variant, upstream-variant-2KB
rs10953368 -- 102,465,537(+) TGGTG(G/T)GGAGT intron-variant, upstream-variant-2KB
rs111295263 -- 102,465,777(+) GTGCA(A/G)AGCCT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs113009525 -- 102,465,173(+) CCGGG(C/T)AGCGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11538919 -- 102,465,859(+) CCCAA(A/G)CTCCT downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR5090 Gene

Variant ID Type Subtype PubMed ID
dgv11540n54 CNV loss 21841781
dgv6538n100 CNV gain 25217958
nsv428182 CNV gain 18775914
nsv464664 CNV gain 19166990
nsv464665 CNV loss 19166990
nsv5879 CNV deletion 18451855
nsv607998 CNV gain+loss 21841781
nsv607999 CNV loss 21841781
nsv608003 CNV gain 21841781
nsv8192 CNV gain 18304495
nsv831083 CNV loss 17160897

Relevant External Links for MIR5090 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5090

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5090 Gene

Disorders for MIR5090 Gene

Relevant External Links for MIR5090

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5090

No disorders were found for MIR5090 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5090 Gene

Publications for MIR5090 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. (PMID: 22427655) Chan K.M. … Zhang Z. (J. Biol. Chem. 2012) 4 64
  4. Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation. (PMID: 22645314) Shen Z. … Prasanth S.G. (Mol. Cell. Biol. 2012) 4 64
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64

Products for MIR5090 Gene

Sources for MIR5090 Gene

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