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MIR509-3 Gene(RNA Gene)

MicroRNA 509-3

GCID:
GC0XM147259
GIFtS:
19
Genes Participants
UDN Logo

Aliases for MIR509-3 Gene

Subcategory (RNA class) for MIR509-3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR509-3 Gene

  • MicroRNA 509-3 2 3 5
  • Hsa-Mir-509-3 3
  • Mir-509-3 3
  • MIRN509-3 3

External Ids for MIR509-3 Gene

ORGUL Members for MIR509-3 Gene

Previous HGNC Symbols for MIR509-3 Gene

  • MIRN509-3

Previous GeneCards Identifiers for MIR509-3 Gene

  • GC0XM146157
  • GC0XM146341

Summaries for MIR509-3 Gene

Entrez Gene Summary for MIR509-3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR509-3 Gene

MIR509-3 (MicroRNA 509-3) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR509-3 Gene

Genomics for MIR509-3 Gene

Products:

  1. Regulatory Element

Genomic Location for MIR509-3 Gene

Chromosome:
X
Start:
147,259,652 bp from pter
End:
147,259,726 bp from pter
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR509-3 Gene

Genes around MIR509-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR509-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR509-3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR509-3 Gene

No data available for Regulatory Elements for MIR509-3 Gene

Proteins for MIR509-3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR509-3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR509-3 Gene

Domains & Families for MIR509-3 Gene

Gene Families for MIR509-3 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR509-3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR509-3 Gene

Function for MIR509-3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR509-3 Gene

Localization for MIR509-3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR509-3 Gene

Pathways & Interactions for MIR509-3 Gene

SuperPathways for MIR509-3 Gene

PathCards logo More details on SuperPathways for MIR509-3
No Data Available

Interacting Proteins for MIR509-3 Gene

Gene Ontology (GO) - Biological Process for MIR509-3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR509-3 Gene

Drugs & Compounds for MIR509-3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR509-3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR509-3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR509-3 Gene

No ASD Table

Relevant External Links for MIR509-3 Gene

GeneLoc Exon Structure for
MIR509-3
ECgene alternative splicing isoforms for
MIR509-3

Expression for MIR509-3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR509-3 Gene

mRNA expression in normal human tissues for MIR509-3 Gene
mRNA expression by GTEx for MIR509-3 Gene
genes like me logo Genes that share expression patterns with MIR509-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR509-3 Gene

Orthologs for MIR509-3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR509-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-509b 35
  • 72 (a)
 OneToOne
Species where no ortholog for MIR509-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR509-3 Gene

ENSEMBL:
Gene Tree for MIR509-3 (if available)
TreeFam:
Gene Tree for MIR509-3 (if available)

Paralogs for MIR509-3 Gene

No data available for Paralogs for MIR509-3 Gene

Variants for MIR509-3 Gene

Sequence variations from dbSNP and Humsavar for MIR509-3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1003637687 -- 147,259,744(+) TGAGG(A/T)TGGCA intron-variant, upstream-variant-2KB
rs1008177544 -- 147,260,137(+) AGCAG(A/G)AGGGA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1008224337 -- 147,259,233(+) AAAAG(G/T)TAAGT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1011047740 -- 147,259,288(+) AAAAT(G/T)AGAAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1011598908 -- 147,259,507(+) AGGCA(A/C)CTAAG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR509-3 Gene

Variant ID Type Subtype PubMed ID
esv2740575 CNV deletion 23290073
esv2758898 CNV gain 17122850
esv35128 CNV gain 17911159
nsv508808 CNV insertion 20534489
nsv521982 CNV gain 19592680

Relevant External Links for MIR509-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR509-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR509-3 Gene

Disorders for MIR509-3 Gene

Relevant External Links for MIR509-3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR509-3

No disorders were found for MIR509-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR509-3 Gene

Publications for MIR509-3 Gene

  1. MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma. (PMID: 25815776) Su Z. … Lai Y. (Mol Med Rep 2015) 3 64
  2. Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A. (PMID: 24802056) Yoon S. … Baek K. (Mol. Cells 2014) 3 64
  3. The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells. (PMID: 24882622) Wang Y. … Ye L. (Cancer Lett. 2014) 3 64
  4. Regulation of RAB5C Is Important for the Growth Inhibitory Effects of MiR-509 in Human Precursor-B Acute Lymphoblastic Leukemia. (PMID: 25368993) Tan Y.S. … Cheng W.C. (PLoS ONE 2014) 3 64
  5. Tumor suppressive miR-509-5p contributes to cell migration, proliferation and antiapoptosis in renal cell carcinoma. (PMID: 23619562) Zhang W.B. … Zheng X.M. (Ir J Med Sci 2013) 3 64

Products for MIR509-3 Gene

Sources for MIR509-3 Gene

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