Aliases for MIR509-3 Gene
Subcategory (RNA class) for MIR509-3 Gene
Quality Score for this RNA gene is
External Ids for MIR509-3 Gene
- HGNC: 33675
- Entrez Gene: 100126337
- Ensembl: ENSG00000212014
- OMIM: 300876
- miRBase: hsa-mir-509-3
ORGUL Members for MIR509-3 Gene
Previous HGNC Symbols for MIR509-3 Gene
- MIRN509-3
Previous GeneCards Identifiers for MIR509-3 Gene
- GC0XM146157
- GC0XM146341
Summaries for MIR509-3 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR509-3 Gene
MIR509-3 (MicroRNA 509-3) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR509-3 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR509-3 Gene
Genomics for MIR509-3 Gene
Regulatory Element Products
Genomic Locations for MIR509-3 Gene
- chrX:147,259,652-147,259,726
- (GRCh38/hg38)
- Size:
- 75 bases
- Orientation:
- Minus strand
- chrX:146,341,170-146,341,244
- (GRCh37/hg19)
Genomic View for MIR509-3 Gene
- Cytogenetic band:
-
- Xq27.3 by Ensembl
- Xq27.3 by Entrez Gene
- Xq27.3 by HGNC


RefSeq DNA sequence for MIR509-3 Gene
No data available for GeneHancer (GH) Regulatory Elements for MIR509-3 Gene
Proteins for MIR509-3 Gene
Post-translational modifications for MIR509-3 Gene
Antibody Products
- Search GeneTex for Antibodies for MIR509-3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR509-3
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- Search GeneTex for Proteins for MIR509-3
No data available for DME Specific Peptides for MIR509-3 Gene
Domains & Families for MIR509-3 Gene
Gene Families for MIR509-3 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR509-3 Gene
Function for MIR509-3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 28111633 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR509-3
-
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CRISPR Products
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- Applied Biological Materials CRISPR for MIR509-3
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR509-3
Clone Products
- GenScript: Custom all cDNA clones Services for MIR509-3
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR509-3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR509-3 Gene
Localization for MIR509-3 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR509-3 Gene
Pathways & Interactions for MIR509-3 Gene
Interacting Proteins for MIR509-3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010628 | positive regulation of gene expression | IGI | 28111633 |
GO:0010629 | negative regulation of gene expression | IDA | 28111633 |
GO:0035195 | gene silencing by miRNA | IDA | 28111633 |
GO:0060045 | positive regulation of cardiac muscle cell proliferation | IDA | 28111633 |
No data available for Pathways by source and SIGNOR curated interactions for MIR509-3 Gene
Transcripts for MIR509-3 Gene
mRNA/cDNA for MIR509-3 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR509-3
- Applied Biological Materials CRISPR for MIR509-3
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR509-3
Clone Products
- GenScript: Custom all cDNA clones Services for MIR509-3
- VectorBuilder custom plasmid, inducible vectors for MIR509-3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR509-3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR509-3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR509-3 Gene
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR509-3 Gene
Orthologs for MIR509-3 Gene
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-509b 34 |
|
OneToOne |
- Species where no ortholog for MIR509-3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR509-3 Gene
No data available for Paralogs for MIR509-3 Gene
Variants for MIR509-3 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1003637687 | -- | 147,259,744(-) | A/T | upstream_transcript_variant | |
rs1008177544 | -- | 147,260,137(-) | G/A | upstream_transcript_variant | |
rs1008224337 | -- | 147,259,233(-) | T/G | downstream_transcript_variant | |
rs1011047740 | -- | 147,259,288(-) | G/T | downstream_transcript_variant | |
rs1011598908 | -- | 147,259,507(-) | C/A | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2740575 | CNV | deletion | 23290073 |
esv2758898 | CNV | gain | 17122850 |
esv35128 | CNV | gain | 17911159 |
nsv508808 | CNV | insertion | 20534489 |
nsv521982 | CNV | gain | 19592680 |
Additional Variant Information for MIR509-3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR509-3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR509-3 Gene
Disorders for MIR509-3 Gene
Additional Disease Information for MIR509-3
No disorders were found for MIR509-3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR509-3 Gene
Publications for MIR509-3 Gene
- MicroRNAs regulating meis1 expression and inducing cardiomyocyte proliferation. (PMID: 28111633) Pandey R … Ahmed RP (Cardiovascular regenerative medicine 2016) 3 58
- MiR-509-3-5p causes aberrant mitosis and anti-proliferative effect by suppression of PLK1 in human lung cancer A549 cells. (PMID: 27498003) Wang XH … Li SY (Biochemical and biophysical research communications 2016) 3 58
- miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. (PMID: 27036018) Pan Y … Gunaratne PH (Oncotarget 2016) 3 58
- MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma. (PMID: 25815776) Su Z … Lai Y (Molecular medicine reports 2015) 3 58
- Regulation of RAB5C is important for the growth inhibitory effects of MiR-509 in human precursor-B acute lymphoblastic leukemia. (PMID: 25368993) Tan YS … Cheng WC (PloS one 2014) 3 58
Products for MIR509-3 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR509-3
- VectorBuilder custom plasmid, inducible vectors for MIR509-3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR509-3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR509-3
- Search GeneTex for Proteins for MIR509-3
Sources for MIR509-3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew