Aliases
for MIR509-3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| MicroRNA 509-31 2 | | MIRN509-31 2 | | mir-509-39 |
| External Ids: | HGNC: 336751 | Entrez Gene: 1001263372 | Ensembl: ENSG000002120147 | OMIM: 3008765 |
Export aliases for MIR509-3 gene to outside databasesPrevious GC identifer: GC0XM146157
|---|
Summaries
for MIR509-3 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for MIR509-3 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
GeneCards Summary for MIR509-3 Gene:
MIR509-3 (microRNA 509-3) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR509-3 include renal cell carcinoma.
|
Genomic Views
for MIR509-3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for MIR509-3
Other transcription factors
Search Chromatin IP Primers for MIR509-3
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR509-3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: Xq27.3 HGNC cytogenetic band: Xq27.3MIR509-3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM146341: view genomic region (via miRBase)
(about GC identifiers)
Start:
|
146,341,170 bp from pter |
End:
|
146,341,244 bp from pter |
Size:
|
75 bases |
Orientation:
|
minus strand |
|
Proteins
for MIR509-3 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB: --
|
Domains /
Families
for MIR509-3 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
MIR: ncRNAs / Micro RNAs
-- |
Function
for MIR509-3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR509-3 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for MIR509-3  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR509-3 |
Localization
for MIR509-3 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIR509-3 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR509-3
Interactions:
Search GeneGlobe Interaction Network for MIR509-3
|
Drugs & Compounds
for MIR509-3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for MIR509-3
|
Transcripts
for MIR509-3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000390725(miRNA)
GeneLoc Exon Structure
|
Expression
for MIR509-3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR509-3:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
MIR509-3 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
Custom PCR Arrays for MIR509-3
Primer
Products: |  | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR509-3 | | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR509-3 | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR509-3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR509-3 |
Orthologs
for MIR509-3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of human and chimp.
Orthologs for MIR509-3 gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chimpanzee
(Pan troglodytes) |
Mammalia |
ptr-mir-509b6 |
ptr-mir-509b |
72(a) |
1 ↔ 1 |
X(148005562-148005654) ENSPTRG00000032257 |
ENSEMBL Gene Tree for MIR509-3 (if available)
TreeFam Gene Tree for MIR509-3 (if available) |
Paralogs
for MIR509-3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Genomic Variants
for MIR509-3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
TryGeneCards Plus | Structural Variations
Database of Genomic Variants (DGV) 5 variations for MIR509-3: About this table
| | Site Specific Mutation Identification with PCR Assays |
|
Disorders
/ Diseases
for MIR509-3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 300876
OMIM disorders: --
1  disease for MIR509-3:
About MalaCardsrenal cell carcinoma
MIR509-3 for disorders About GeneDecksing
Export disorders for MIR509-3 gene to outside databases
|
Publications
for MIR509-3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for MIR509-3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MIR509-3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma. (PubMed id 22369946)1 Zhai Q....Lu R. (Biochem. Biophys. Res. Commun. 2012)
- Analysis of gene expression in normal and neoplastic human testis: new roles of RNA. (PubMed id 17573847)1 Novotny G.W....Leffers H. (Int. J. Androl. 2007)
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (Cell 2007)
- miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (Nucleic Acids Res. 2006)
- Identification of hundreds of conserved and nonconserved human microRNAs. (PubMed id 15965474)1 Bentwich I....Bentwich Z. (Nat. Genet. 2005)
|
External Searches for MIR509-3 gene (in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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|
Genome Databases showing MIR509-3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing MIR509-3 gene
(According to HUGE)
About This Section
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Specialized Databases showing MIR509-3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR509-3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for MIR509-3 gene:
Search GeneIP for patents involving MIR509-3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR509-3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat MIR509-3 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing MIR509-3 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR509-3 | | Predesigned siRNA for gene silencing in human, mouse, rat MIR509-3 | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR509-3 | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR509-3 | | | Custom PCR Arrays for MIR509-3 | | Search Chromatin IP Primers for MIR509-3 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR509-3 | | Search GeneGlobe Interaction Network for MIR509-3 | | | Search Regulatory tfbs for MIR509-3 |
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 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR509-3 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for MIR509-3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR509-3 |
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