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Aliases for MIR508 Gene

Subcategory (RNA class) for MIR508 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR508 Gene

  • MicroRNA 508 2 3
  • Hsa-Mir-508 3
  • MIRN508 3

External Ids for MIR508 Gene

Previous HGNC Symbols for MIR508 Gene

  • MIRN508

Previous GeneCards Identifiers for MIR508 Gene

  • GC0XM146127
  • GC0XM146318

Summaries for MIR508 Gene

Entrez Gene Summary for MIR508 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR508 Gene

MIR508 (MicroRNA 508) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR508 Gene

Genomics for MIR508 Gene

Genomic Location for MIR508 Gene

Start:
147,236,913 bp from pter
End:
147,237,027 bp from pter
Size:
115 bases
Orientation:
Minus strand

Genomic View for MIR508 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR508 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR508 Gene

No data available for Regulatory Elements for MIR508 Gene

Proteins for MIR508 Gene

Post-translational modifications for MIR508 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR508 Gene

Domains for MIR508 Gene

Gene Families for MIR508 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR508: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR508 Gene

Function for MIR508 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR508 Gene

Localization for MIR508 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR508 Gene

Pathways for MIR508 Gene

SuperPathways for MIR508 Gene

No Data Available

Interacting Proteins for MIR508 Gene

Gene Ontology (GO) - Biological Process for MIR508 Gene

None

No data available for Pathways by source for MIR508 Gene

Transcripts for MIR508 Gene

mRNA/cDNA for MIR508 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR508 Gene

No ASD Table

Relevant External Links for MIR508 Gene

GeneLoc Exon Structure for
MIR508
ECgene alternative splicing isoforms for
MIR508

Expression for MIR508 Gene

mRNA expression in normal human tissues for MIR508 Gene

genes like me logo Genes that share expressions with MIR508: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR508 Gene

Orthologs for MIR508 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR508 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-508 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
OneToOne
Species with no ortholog for MIR508:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR508 Gene

ENSEMBL:
Gene Tree for MIR508 (if available)
TreeFam:
Gene Tree for MIR508 (if available)

Paralogs for MIR508 Gene

No data available for Paralogs for MIR508 Gene

Variants for MIR508 Gene

Sequence variations from dbSNP and Humsavar for MIR508 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5904725 -- 147,237,775(+) TGCAC(C/T)GAATA upstream-variant-2KB
rs5905014 -- 147,237,884(+) AGGAA(C/G)CTCCA upstream-variant-2KB
rs5905015 -- 147,238,543(+) TGCAT(A/C)CATGT upstream-variant-2KB
rs28689589 -- 147,238,709(+) AATAG(A/C)GGTTA upstream-variant-2KB
rs28699994 -- 147,237,245(+) CATAT(A/T)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR508 Gene

Variant ID Type Subtype PubMed ID
dgv2488e1 CNV Complex 17122850
esv35128 CNV Gain 17911159
nsv522829 CNV Gain 19592680
nsv521982 CNV Gain 19592680
nsv508808 CNV Insertion 20534489

Relevant External Links for MIR508 Gene

HapMap Linkage Disequilibrium report
MIR508

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR508 Gene

Disorders for MIR508 Gene

No disorders were found for MIR508 Gene.

No data available for UniProtKB/Swiss-Prot for MIR508 Gene

Publications for MIR508 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma. (PMID: 22369946) Zhai Q. … Lu R. (Biochem. Biophys. Res. Commun. 2012) 3
  5. Expression of miR-126 and miR-508-5p in endothelial progenitor cells is associated with the prognosis of chronic heart failure patients. (PMID: 23465244) Qiang L. … Jing W. (Int. J. Cardiol. 2013) 3

Products for MIR508 Gene

Sources for MIR508 Gene

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