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Aliases for MIR506 Gene

Subcategory (RNA class) for MIR506 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR506 Gene

  • MicroRNA 506 2 3 5
  • Hsa-Mir-506 3
  • Mir-506 3
  • MIRN506 3

External Ids for MIR506 Gene

Previous HGNC Symbols for MIR506 Gene

  • MIRN506

Previous GeneCards Identifiers for MIR506 Gene

  • GC0XM146121
  • GC0XM146312

Summaries for MIR506 Gene

Entrez Gene Summary for MIR506 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR506 Gene

MIR506 (MicroRNA 506) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR506 Gene

Genomics for MIR506 Gene

Genomic Location for MIR506 Gene

Chromosome:
X
Start:
147,230,720 bp from pter
End:
147,230,843 bp from pter
Size:
124 bases
Orientation:
Minus strand

Genomic View for MIR506 Gene

Genes around MIR506 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR506 Gene

No data available for Regulatory Elements for MIR506 Gene

Proteins for MIR506 Gene

Post-translational modifications for MIR506 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR506 Gene

Domains & Families for MIR506 Gene

Gene Families for MIR506 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR506: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR506 Gene

Function for MIR506 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR506 Gene

Localization for MIR506 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR506 Gene

Pathways & Interactions for MIR506 Gene

SuperPathways for MIR506 Gene

No Data Available

Interacting Proteins for MIR506 Gene

Gene Ontology (GO) - Biological Process for MIR506 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR506 Gene

Drugs & Compounds for MIR506 Gene

No Compound Related Data Available

Transcripts for MIR506 Gene

mRNA/cDNA for MIR506 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR506 Gene

No ASD Table

Relevant External Links for MIR506 Gene

GeneLoc Exon Structure for
MIR506
ECgene alternative splicing isoforms for
MIR506

Expression for MIR506 Gene

mRNA expression in normal human tissues for MIR506 Gene

genes like me logo Genes that share expression patterns with MIR506: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR506 Gene

Orthologs for MIR506 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR506 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-506 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR506:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR506 Gene

ENSEMBL:
Gene Tree for MIR506 (if available)
TreeFam:
Gene Tree for MIR506 (if available)

Paralogs for MIR506 Gene

No data available for Paralogs for MIR506 Gene

Variants for MIR506 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR506 Gene

Variant ID Type Subtype PubMed ID
dgv2488e1 CNV Complex 17122850
esv35128 CNV Gain 17911159
nsv522829 CNV Gain 19592680
nsv521982 CNV Gain 19592680

Relevant External Links for MIR506 Gene

HapMap Linkage Disequilibrium report
MIR506

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR506 Gene

Disorders for MIR506 Gene

Relevant External Links for MIR506

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR506

No disorders were found for MIR506 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR506 Gene

Publications for MIR506 Gene

  1. MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer. (PMID: 25230372) Sun Y. … Zhang W. (J. Pathol. 2015) 3 67
  2. Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers. (PMID: 25995442) Liu G. … Zhang W. (J. Natl. Cancer Inst. 2015) 3
  3. MiR-506 Is Down-Regulated in Clear Cell Renal Cell Carcinoma and Inhibits Cell Growth and Metastasis via Targeting FLOT1. (PMID: 25793370) Yang F.Q. … Zheng J.H. (PLoS ONE 2015) 3
  4. miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer. (PMID: 24608427) Wen S.Y. … Zhang Z.G. (Oncogene 2015) 3
  5. Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-I_B p65 to evoke reactive oxygen species generation and p53 activation. (PMID: 24469051) Yin M. … Zhang B. (Oncogene 2015) 3

Products for MIR506 Gene

Sources for MIR506 Gene

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