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Aliases for MIR506 Gene

Subcategory (RNA class) for MIR506 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR506 Gene

  • MicroRNA 506 2 3 5
  • Hsa-Mir-506 3
  • Mir-506 3
  • MIRN506 3

External Ids for MIR506 Gene

Previous HGNC Symbols for MIR506 Gene

  • MIRN506

Previous GeneCards Identifiers for MIR506 Gene

  • GC0XM146121
  • GC0XM146312

Summaries for MIR506 Gene

Entrez Gene Summary for MIR506 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR506 Gene

MIR506 (MicroRNA 506) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR506 Gene

Genomics for MIR506 Gene

Genomic Location for MIR506 Gene

Chromosome:
X
Start:
147,230,720 bp from pter
End:
147,230,843 bp from pter
Size:
124 bases
Orientation:
Minus strand

Genomic View for MIR506 Gene

Genes around MIR506 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR506 Gene

No data available for Regulatory Elements for MIR506 Gene

Proteins for MIR506 Gene

Post-translational modifications for MIR506 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR506 Gene

Domains & Families for MIR506 Gene

Gene Families for MIR506 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR506: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR506 Gene

Function for MIR506 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR506 Gene

Localization for MIR506 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR506 Gene

Pathways & Interactions for MIR506 Gene

SuperPathways for MIR506 Gene

No Data Available

Interacting Proteins for MIR506 Gene

Gene Ontology (GO) - Biological Process for MIR506 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR506 Gene

Transcripts for MIR506 Gene

mRNA/cDNA for MIR506 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR506 Gene

No ASD Table

Relevant External Links for MIR506 Gene

GeneLoc Exon Structure for
MIR506
ECgene alternative splicing isoforms for
MIR506

Expression for MIR506 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR506 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR506 Gene:

MIR506
genes like me logo Genes that share expression patterns with MIR506: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR506 Gene

Orthologs for MIR506 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR506 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-506 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR506 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR506 Gene

ENSEMBL:
Gene Tree for MIR506 (if available)
TreeFam:
Gene Tree for MIR506 (if available)

Paralogs for MIR506 Gene

No data available for Paralogs for MIR506 Gene

Variants for MIR506 Gene

Sequence variations from dbSNP and Humsavar for MIR506 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1004080371 -- 147,232,671(+) CATAA(A/C)AACAA intron-variant, upstream-variant-2KB
rs1009068054 -- 147,231,235(+) AATTA(C/T)TTCAC intron-variant, upstream-variant-2KB
rs1013360872 -- 147,230,386(+) AGGAA(A/G)GAAGA intron-variant, downstream-variant-500B
rs1015031681 -- 147,232,346(+) TCACC(A/G)TGTTG intron-variant, upstream-variant-2KB
rs1018679556 -- 147,230,897(+) CCAGA(C/G)AACCT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR506 Gene

Variant ID Type Subtype PubMed ID
esv2758898 CNV gain 17122850
esv35128 CNV gain 17911159
nsv521982 CNV gain 19592680
nsv522829 CNV gain 19592680

Relevant External Links for MIR506 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR506

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR506 Gene

Disorders for MIR506 Gene

Relevant External Links for MIR506

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR506

No disorders were found for MIR506 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR506 Gene

Publications for MIR506 Gene

  1. Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells. (PMID: 26935526) Zhang M. … Jia X. (Oncol. Rep. 2016) 3 64
  2. MiR-506 functions as a tumor suppressor in glioma by targeting STAT3. (PMID: 26554866) Peng T. … Luan Y. (Oncol. Rep. 2016) 3 64
  3. Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma. (PMID: 27345473) Li S.P. … Guan Q.L. (Med. Sci. Monit. 2016) 3 64
  4. MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression. (PMID: 27371108) Cheng R.F. … Sun Y. (Chin J Cancer 2016) 3 64
  5. MicroRNA-506 Inhibits Malignancy of Colorectal Carcinoma Cells by Targeting LAMC1. (PMID: 27993882) Zu C. … Zhang G. (Ann. Clin. Lab. Sci. 2016) 3 64

Products for MIR506 Gene

Sources for MIR506 Gene

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