Aliases for MIR506 Gene
Subcategory (RNA class) for MIR506 Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR506 Gene
- HGNC: 32143
- Entrez Gene: 574511
- Ensembl: ENSG00000207731
- OMIM: 300877
- miRBase: hsa-mir-506
ORGUL Members for MIR506 Gene
Previous HGNC Symbols for MIR506 Gene
- MIRN506
Previous GeneCards Identifiers for MIR506 Gene
- GC0XM146121
- GC0XM146312
Summaries for MIR506 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR506 Gene
MIR506 (MicroRNA 506) is an RNA Gene, and is affiliated with the miRNA class.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR506 Gene
Genomics for MIR506 Gene
Regulatory Element Products
Genomic Location for MIR506 Gene
- Chromosome:
- X
- Start:
- 147,230,720 bp from pter
- End:
- 147,230,843 bp from pter
- Size:
- 124 bases
- Orientation:
- Minus strand
Genomic View for MIR506 Gene
Genes around MIR506 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq27.3 by Ensembl
- Xq27.3 by Entrez Gene
- Xq27.3 by HGNC
MIR506 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR506 Gene
No data available for Regulatory Elements for MIR506 Gene
Proteins for MIR506 Gene
Post-translational modifications for MIR506 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR506
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR506
- Origene Custom Protein Services for MIR506
- Search GeneTex for Proteins for MIR506
Assay Products
No data available for DME Specific Peptides for MIR506 Gene
Domains & Families for MIR506 Gene
Gene Families for MIR506 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR506 Gene
Function for MIR506 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR506
-
- Search ViGene Biosciences for MIR506
CRISPR Products
- Browse CRISPR knockouts for MIR506
miRNA Products
- Search ViGene Biosciences for MIR506
-
Origene geneexpression products in human, mouse, rat for MIR506
- Browse OriGene miRNA Products For MIR506
Inhibitory RNA Products
- Search ViGene Biosciences for MIR506
Clone Products
- GenScript: Custom all cDNA clones Services for MIR506
- VectorBuilder custom plasmid, inducible vectors for MIR506
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR506
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for MIR506
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR506 Gene
Localization for MIR506 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR506 Gene
Transcripts for MIR506 Gene
mRNA/cDNA for MIR506 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR506
miRNA Products
- Search ViGene Biosciences for MIR506
-
Origene geneexpression products in human, mouse, rat for MIR506
- Browse OriGene miRNA Products For MIR506
Inhibitory RNA Products
- Search ViGene Biosciences for MIR506
Clone Products
- GenScript: Custom all cDNA clones Services for MIR506
- VectorBuilder custom plasmid, inducible vectors for MIR506
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR506
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for MIR506 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR506 Gene:
MIR506Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR506 Gene
Orthologs for MIR506 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-506 35 |
|
OneToOne |
- Species where no ortholog for MIR506 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR506 Gene
No data available for Paralogs for MIR506 Gene
Variants for MIR506 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1004080371 | -- | 147,232,671(+) | CATAA(A/C)AACAA | intron-variant, upstream-variant-2KB | |
| rs1009068054 | -- | 147,231,235(+) | AATTA(C/T)TTCAC | intron-variant, upstream-variant-2KB | |
| rs1013360872 | -- | 147,230,386(+) | AGGAA(A/G)GAAGA | intron-variant, downstream-variant-500B | |
| rs1015031681 | -- | 147,232,346(+) | TCACC(A/G)TGTTG | intron-variant, upstream-variant-2KB | |
| rs1018679556 | -- | 147,230,897(+) | CCAGA(C/G)AACCT | intron-variant, downstream-variant-500B, upstream-variant-2KB |
Relevant External Links for MIR506 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR506
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR506 Gene
Disorders for MIR506 Gene
Relevant External Links for MIR506
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR506
No disorders were found for MIR506 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR506 Gene
Publications for MIR506 Gene
- Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells. (PMID: 26935526) Zhang M. … Jia X. (Oncol. Rep. 2016) 3 64
- MiR-506 functions as a tumor suppressor in glioma by targeting STAT3. (PMID: 26554866) Peng T. … Luan Y. (Oncol. Rep. 2016) 3 64
- Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma. (PMID: 27345473) Li S.P. … Guan Q.L. (Med. Sci. Monit. 2016) 3 64
- MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression. (PMID: 27371108) Cheng R.F. … Sun Y. (Chin J Cancer 2016) 3 64
- MicroRNA-506 Inhibits Malignancy of Colorectal Carcinoma Cells by Targeting LAMC1. (PMID: 27993882) Zu C. … Zhang G. (Ann. Clin. Lab. Sci. 2016) 3 64
Products for MIR506 Gene
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- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse ELISAs
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR506
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- Browse CRISPR knockouts for MIR506
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse OriGene miRNA Products For MIR506
- GenScript: Custom all cDNA clones Services for MIR506
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR506
- VectorBuilder custom plasmid, inducible vectors for MIR506
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR506
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR506 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (128) Genetics Home Reference
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer