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Aliases for MIR506 Gene

Subcategory (RNA class) for MIR506 Gene


Quality Score for this RNA gene is


Aliases for MIR506 Gene

  • MicroRNA 506 2 3
  • Hsa-Mir-506 3
  • MIRN506 3

External Ids for MIR506 Gene

Previous HGNC Symbols for MIR506 Gene

  • MIRN506

Previous GeneCards Identifiers for MIR506 Gene

  • GC0XM146121
  • GC0XM146312

Summaries for MIR506 Gene

Entrez Gene Summary for MIR506 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR506 Gene

MIR506 (MicroRNA 506) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR506 include primary biliary cirrhosis.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR506 Gene

Genomics for MIR506 Gene

Genomic Location for MIR506 Gene

147,230,720 bp from pter
147,230,843 bp from pter
124 bases
Minus strand

Genomic View for MIR506 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR506 Gene

No data available for Regulatory Elements for MIR506 Gene

Proteins for MIR506 Gene

Post-translational modifications for MIR506 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR506 Gene

Domains for MIR506 Gene

Gene Families for MIR506 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR506: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR506 Gene

Function for MIR506 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR506 Gene

Localization for MIR506 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR506 Gene

Pathways for MIR506 Gene

SuperPathways for MIR506 Gene

No Data Available

Interacting Proteins for MIR506 Gene

Gene Ontology (GO) - Biological Process for MIR506 Gene


No data available for Pathways by source for MIR506 Gene

Transcripts for MIR506 Gene

mRNA/cDNA for MIR506 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR506

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR506 Gene

No ASD Table

Relevant External Links for MIR506 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR506 Gene

mRNA expression in normal human tissues for MIR506 Gene

genes like me logo Genes that share expressions with MIR506: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR506 Gene

Orthologs for MIR506 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR506 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-506 36
  • 100 (a)
Species with no ortholog for MIR506:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR506 Gene

Gene Tree for MIR506 (if available)
Gene Tree for MIR506 (if available)

Paralogs for MIR506 Gene

No data available for Paralogs for MIR506 Gene

Variants for MIR506 Gene

Sequence variations from dbSNP and Humsavar for MIR506 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5951785 -- 147,230,358(+) TCCCT(A/G)AAAAG downstream-variant-500B
rs5951952 -- 147,230,292(+) ACTTC(A/G)TAAGA downstream-variant-500B
rs149247466 -- 147,230,285(+) GGAGA(A/T)CACTT downstream-variant-500B
rs186707622 -- 147,230,267(+) AGTGT(A/G)TCTAA downstream-variant-500B
rs373091435 -- 147,230,478(+) GAAAA(A/G)GAAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR506 Gene

Variant ID Type Subtype PubMed ID
dgv2488e1 CNV Complex 17122850
esv35128 CNV Gain 17911159
nsv522829 CNV Gain 19592680
nsv521982 CNV Gain 19592680

Relevant External Links for MIR506 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR506 Gene

Disorders for MIR506 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR506 Gene in MalaCards »

(1) Diseases for MIR506 Gene including...

genes like me logo Genes that share disorders with MIR506: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR506 Gene

Publications for MIR506 Gene

  1. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I. … Bentwich Z. (Nat. Genet. 2005) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. The role of miR-506 in transformed 16HBE cells induced by anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide. (PMID: 21726609) Zhao Y. … Jiang Y. (Toxicol. Lett. 2011) 3
  4. Up-regulation of microRNA 506 leads to decreased Cl-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. (PMID: 22383162) Banales J.M. … LaRusso N.F. (Hepatology 2012) 3
  5. Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. (PMID: 23410973) Yang D. … Zhang W. (Cancer Cell 2013) 3

Products for MIR506 Gene

Sources for MIR506 Gene

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