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Aliases for MIR5047 Gene

Subcategory (RNA class) for MIR5047 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5047 Gene

  • MicroRNA 5047 2 3
  • DDX5 4 5
  • DEAD-Box Helicase 5 5
  • DEAD Box Protein 5 4
  • RNA Helicase P68 4
  • Hsa-Mir-5047 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • G17P1 4
  • HLR1 4
  • HELR 4

External Ids for MIR5047 Gene

Previous GeneCards Identifiers for MIR5047 Gene

  • GC17U901654
  • GC17M062501

Summaries for MIR5047 Gene

Entrez Gene Summary for MIR5047 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5047 Gene

MIR5047 (MicroRNA 5047) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is DDX17.

UniProtKB/Swiss-Prot for MIR5047 Gene

  • Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5047 Gene

Genomics for MIR5047 Gene

Regulatory Elements for MIR5047 Gene

Enhancers for MIR5047 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR5047 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5047 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR5047 Gene

Chromosome:
17
Start:
64,499,616 bp from pter
End:
64,508,199 bp from pter
Size:
8,584 bases
Orientation:
Minus strand

Genomic View for MIR5047 Gene

Genes around MIR5047 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5047 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5047 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5047 Gene

Proteins for MIR5047 Gene

  • Protein details for MIR5047 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17844-DDX5_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX5
    Protein Accession:
    P17844
    Secondary Accessions:
    • B4DLW8
    • B5BU21
    • D3DU32
    • E7ETL9
    • O75681
    • Q53Y61

    Protein attributes for MIR5047 Gene

    Size:
    614 amino acids
    Molecular mass:
    69148 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).
    • Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).
    • Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).

    Three dimensional structures from OCA and Proteopedia for MIR5047 Gene

    Alternative splice isoforms for MIR5047 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR5047 Gene

Post-translational modifications for MIR5047 Gene

  • Arg-502 is dimethylated, probably to asymmetric dimethylarginine.
  • Polyubiquitinated, leading to proteasomal degradation.
  • Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.
  • Ubiquitination at Lys 56, Lys 91, Lys 236, Lys 340, Lys 351, Lys 375, Lys 388, Lys 411, Lys 437, Lys 451, and Lys 529
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR5047 Gene

Gene Families for MIR5047 Gene

Graphical View of Domain Structure for InterPro Entry

P17844

UniProtKB/Swiss-Prot:

DDX5_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
genes like me logo Genes that share domains with MIR5047: view

No data available for Suggested Antigen Peptide Sequences for MIR5047 Gene

Function for MIR5047 Gene

Molecular function for MIR5047 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3 transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.

Enzyme Numbers (IUBMB) for MIR5047 Gene

Gene Ontology (GO) - Molecular Function for MIR5047 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA --
GO:0003724 RNA helicase activity NAS --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005515 protein binding IPI --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MIR5047: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5047 Gene

Localization for MIR5047 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5047 Gene

Gene Ontology (GO) - Cellular Components for MIR5047 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016020 membrane IDA --
GO:0030529 intracellular ribonucleoprotein complex IDA --
genes like me logo Genes that share ontologies with MIR5047: view

No data available for Subcellular locations from COMPARTMENTS for MIR5047 Gene

Pathways & Interactions for MIR5047 Gene

SuperPathways for MIR5047 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5047 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0009299 mRNA transcription IMP --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0016049 cell growth NAS --
genes like me logo Genes that share ontologies with MIR5047: view

No data available for Pathways by source and SIGNOR curated interactions for MIR5047 Gene

Drugs & Compounds for MIR5047 Gene

No Compound Related Data Available

Transcripts for MIR5047 Gene

mRNA/cDNA for MIR5047 Gene

(37) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5047 Gene

No ASD Table

Relevant External Links for MIR5047 Gene

GeneLoc Exon Structure for
MIR5047
ECgene alternative splicing isoforms for
MIR5047

Expression for MIR5047 Gene

mRNA expression in normal human tissues for MIR5047 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5047 Gene:

MIR5047
genes like me logo Genes that share expression patterns with MIR5047: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5047 Gene

Orthologs for MIR5047 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR5047 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX5 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX5 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX5 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx5 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DDX5 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX5 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 89 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx5 35
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10077 35
  • 42 (a)
ManyToMany
CG10777 35
  • 34 (a)
ManyToMany
Rm62 35
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-17 35
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 35
  • 54 (a)
OneToMany
DBP2 37
Species where no ortholog for MIR5047 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR5047 Gene

ENSEMBL:
Gene Tree for MIR5047 (if available)
TreeFam:
Gene Tree for MIR5047 (if available)

Paralogs for MIR5047 Gene

Paralogs for MIR5047 Gene

Pseudogenes.org Pseudogenes for MIR5047 Gene

genes like me logo Genes that share paralogs with MIR5047: view

Variants for MIR5047 Gene

Relevant External Links for MIR5047 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5047

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5047 Gene

Disorders for MIR5047 Gene

Relevant External Links for MIR5047

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5047

No disorders were found for MIR5047 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5047 Gene

Publications for MIR5047 Gene

  1. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 65
  2. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 65
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  4. Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. (PMID: 25114211) Impens F. … Ribet D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 4 65
  5. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 65

Products for MIR5047 Gene

Sources for MIR5047 Gene

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